About: Dynamics of the upper airway microbiome in the pathogenesis of asthma-associated persistent wheeze in preschool children

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About: Dynamics of the upper airway microbiome in the pathogenesis of asthma-associated persistent wheeze in preschool children Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Dynamics of the upper airway microbiome in the pathogenesis of asthma-associated persistent wheeze in preschool children
Creator	Gern, James Grindle, Kristine Inouye, Michael Kusel, Merci Mok, Danny Pham, Kym Serralha, Michael Troy, Niamh Johnston, Sebastian Bochkov, Yury Holt, Barbara Holt, Kathryn Holt, Patrick Lemanske, Robert Sly, Peter Teo, Shu Judd, Louise Tang, Howard Watts, Stephen
Source	BioRxiv
abstract	Repeated cycles of infection-associated lower airway inflammation drives the pathogenesis of persistent wheezing disease in children. Tracking these events across a birth cohort during their first five years, we demonstrate that >80% of infectious events indeed involve viral pathogens, but are accompanied by a shift in the nasopharyngeal microbiome (NPM) towards dominance by a small range of pathogenic bacterial genera. Unexpectedly, this change in NPM frequently precedes the appearance of viral pathogens and acute symptoms. In non-sensitized children these events are associated only with “transient wheeze” that resolves after age three. In contrast, in children developing early allergic sensitization, they are associated with ensuing development of persistent wheeze, which is the hallmark of the asthma phenotype. This suggests underlying pathogenic interactions between allergic sensitization and antibacterial mechanisms.
has issue date	2017-11-20(xsd:dateTime)
bibo:doi	10.1101/222190
has license	biorxiv
sha1sum (hex)	efeaf1b541bef5a1199ad0edd8e847a23335991b
schema:url	https://doi.org/10.1101/222190
resource representing a document's title	Dynamics of the upper airway microbiome in the pathogenesis of asthma-associated persistent wheeze in preschool children
schema:publication	bioRxiv
resource representing a document's body	covid:efeaf1b541bef5a1199ad0edd8e847a23335991b#body_text
is schema:about of	named entity 'events' named entity 'NPM' named entity 'asthma' named entity 'INFECTION' named entity 'BIRTH COHORT' named entity 'ANTIBACTERIAL' named entity 'TRACKING' named entity 'CONTRAST' named entity 'UNDERLYING' named entity 'CHANGE IN' named entity 'AIRWAY INFLAMMATION' named entity 'DEVELOPMENT' named entity 'BUT' named entity 'phenotype' named entity 'hallmark' named entity 'acute' named entity 'mechanisms' named entity 'pathogenic' named entity 'cycles' named entity 'change' named entity 'wheeze' named entity 'allergic sensitization' named entity 'inflammation' named entity 'nasopharyngeal' named entity 'microbiome' named entity 'URI' named entity 'positively correlated' named entity '16S rRNA' named entity 'Staphylococcus' named entity 'OTUs' named entity 'CSS' named entity 'antibiotics' named entity 'MPGs' named entity 'human metapneumovirus' named entity 'microbial' named entity 'ARIs' named entity 'Kusel' named entity 'Corynebacterium' named entity 'fever' named entity 'inflammatory' named entity 'Kusel' named entity 'inflammation' named entity 'upper airways' named entity 'receptor expression' named entity 'bacterial colonization' named entity 'Kusel' named entity 'assay' named entity 'pathogens' named entity 'distance metric' named entity 'negatively correlated' named entity 'amplicon' named entity 'PCR' named entity 'phenotypes' named entity 'causation' named entity 'viral promotion' named entity 'allergic sensitization' named entity 'Streptococcus' named entity 'genus' named entity 'correlation' named entity 'Streptococcus' named entity 'URI' named entity 'linear regression' named entity 'MPGs' named entity 'Mycoplasma' named entity 'acute illness' named entity 'epidemiological data'

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