About: The hemagglutinin/esterase gene of human coronavirus strain OC43: Phylogenetic relationships to bovine and murine coronaviruses and influenza C virus

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About: The hemagglutinin/esterase gene of human coronavirus strain OC43: Phylogenetic relationships to bovine and murine coronaviruses and influenza C virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The hemagglutinin/esterase gene of human coronavirus strain OC43: Phylogenetic relationships to bovine and murine coronaviruses and influenza C virus
Creator	Zhang, Xuming Kousoulas, Konstantin Storz', Johannes
Source	Elsevier; Medline; PMC
abstract	Abstract The complete nucleotide sequences of the hemagglutinin/esterase (HE) genes of human coronavirus (HCV) strain OC43 and bovine respiratory coronavirus (BRCV) strain G95 were determined from single-stranded cDNA fragments generated by reverse transcription of virus-specific mRNAs and amplified by polymerase chain reaction. An open reading frame of 1272 nucleotides was identified as the putative HE gene by homology to the bovine coronavirus HE gene. This open reading frame encodes a protein of 424 amino acids with an estimated molecular weight of 47.7 kDa. Ten potential N-linked glycosylation sites were predicted in the HE protein of HCV-OC43 while nine of them were present in BRCV-G95. Fourteen cysteine residues were conserved in the HE proteins of both viruses. Two hydrophobic sequences at the N-terminus and the C-terminus may serve as signal peptide and transmembrane anchoring domain, respectively. The predicted HE protein of HCV-OC43 was 95% identical to the HEs of BRCV-G95 and other bovine coronaviruses, and 60% identical to the HEs of mouse hepatitis viruses. Phylogenetic analysis suggests that the HE genes of coronaviruses and influenza C virus have a common ancestral origin, and that bovine coronaviruses and HCV-OC43 are closely related.
has issue date	1992-01-31(xsd:dateTime)
bibo:doi	10.1016/0042-6822(92)90089-8
bibo:pmid	1727608
has license	els-covid
sha1sum (hex)	f0383dfc986d198dd48125704827db59270605f0
schema:url	https://doi.org/10.1016/0042-6822%2892%2990089-8
resource representing a document's title	The hemagglutinin/esterase gene of human coronavirus strain OC43: Phylogenetic relationships to bovine and murine coronaviruses and influenza C virus
has PubMed Central identifier	PMC7131372
has PubMed identifier	1727608
schema:publication	Virology
resource representing a document's body	covid:f0383dfc986d198dd48125704827db59270605f0#body_text
is schema:about of	named entity 'CORONAVIRUSES' named entity 'GENE' named entity 'RELATIONSHIPS' named entity 'HEMAGGLUTININ' named entity 'INFLUENZA C VIRUS' named entity 'MURINE' named entity 'HUMAN CORONAVIRUS STRAIN OC43' named entity 'BOVINE' named entity 'coronaviruses' named entity 'ICV' named entity 'HE2' named entity 'phylogram' named entity 'tissue tropism' named entity 'OC43' named entity 'coronaviruses' named entity 'swine' named entity 'active site' named entity 'epithelial cells' named entity 'viruses' named entity 'nucleotide sequence' named entity 'gene' named entity 'viral proteins' named entity 'active sites' named entity 'OC43' named entity 'OC43' named entity 'HCV' named entity 'murine' named entity 'antigenic' named entity 'phylogenetic relationships' named entity 'ICV' named entity 'MHV' named entity 'HCV' named entity 'ingroup' named entity 'evolution' named entity 'phylogenetic' named entity 'ICV' named entity 'ORFs' named entity 'evolutionarily related' named entity 'hydrophobic' named entity 'hemagglutinin' named entity 'turkeys' named entity 'protein' named entity 'protein' named entity 'OC43' named entity 'HCV' named entity 'protein' named entity 'coronaviruses' named entity 'tumor' named entity 'bovine' named entity 'DNA sequence' named entity 'coronavirus' named entity 'virulent strain' named entity 'ICV' named entity 'glycoprotein' named entity 'coronavirus' named entity 'OC43' named entity 'HCV' named entity 'amino acid sequences' named entity 'MHV' named entity 'coronavirus' named entity 'MHV' named entity 'HCV' named entity 'Infectious Diseases' named entity 'sister taxa' named entity 'epithelial cells' named entity 'hydrophobic' named entity 'MHV' named entity 'A59' named entity 'HCV' named entity 'hydrophilic' named entity 'ICV' named entity 'BCVs' named entity 'nucleotides' named entity 'protein' named entity 'coronavirus' named entity 'gene' named entity 'recombination' named entity 'kDa' named entity 'amino acid sequence'

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