About: Angiotensin converting enzyme-2 as therapeutic target in COVID-19

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Angiotensin converting enzyme-2 as therapeutic target in COVID-19
Creator	Ghaffari, Samad Roshanravan, Neda Ghaffari, Hedayati, Mehdi Mehdi Hedayati,
Source	Elsevier; Medline; PMC
abstract	The pandemic of coronavirus disease 2019 (COVID-19) is a global health emergency that poses a significant threat to world people's health. This outbreak causes major challenges to healthcare systems. Given the lack of effective treatments or vaccine for it, the identification of novel and safe drugs against COVID-19 infection is an urgent need. Angiotensin-converting enzyme 2 (ACE2) is not only an entry receptor of the SARS-CoV-2 virus, the virus that causes COVID-19, but also can protect from lung injury. In this view, we highlighted potential approaches to address ACE2-mediated SARS-CoV-2 virus, including 1) delivering an excessive soluble form of ACE2 (recombinant human ACE2: rhACE2) and 2) inhibition of the interaction between SARS-CoV-2 virus and ACE2 by some compounds with competitive effects (morphine and codeine). Further clinical trials in this regard can reveal a more definite conclusion against the COVID-19 disaster.
has issue date	2020-05-12(xsd:dateTime)
bibo:doi	10.1016/j.dsx.2020.05.022
bibo:pmid	32428864
has license	no-cc
sha1sum (hex)	f0b2a84b0e4230748ac3cd3a6ccfa514fe3d2794
schema:url	https://doi.org/10.1016/j.dsx.2020.05.022
resource representing a document's title	Angiotensin converting enzyme-2 as therapeutic target in COVID-19
has PubMed Central identifier	PMC7214324
has PubMed identifier	32428864
schema:publication	Diabetes Metab Syndr
resource representing a document's body	covid:f0b2a84b0e4230748ac3cd3a6ccfa514fe3d2794#body_text
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