About: Oral efficacy of Vero cell attenuated porcine epidemic diarrhea virus DR13 strain

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Oral efficacy of Vero cell attenuated porcine epidemic diarrhea virus DR13 strain
Creator	Moon, H Park, B Song, D Yang, J Jang, Y Kang, B Oh, J Yoo, H
Source	Elsevier; Medline; PMC
abstract	Abstract A Vero cell attenuated porcine epidemic diarrhea virus (PEDV) strain, DR13, was distinguished from wild-type PEDV using restriction enzyme fragment length polymorphism (RFLP). Cell attenuated DR13 was orally or intramuscularly (IM) administered to late-term pregnant sows, and mortality resulting from the highly virulent PEDV challenge was investigated in passively immunized suckling piglets of the two different groups. The mortality rate of the oral group (13%) was lower than that of the IM group (60%). In particular, the concentration of IgA against PEDV was higher in piglets of sows in the oral group, compared to the IM group. The attenuated DR13 virus remained safe, even after three backpassages in piglets. The findings of this study support the theory that the Vero cell attenuated DR13 virus may be applied as an oral vaccine for inducing specific immunity in late-term pregnant sows with a high margin of protection against PEDV infection.
has issue date	2007-02-28(xsd:dateTime)
bibo:doi	10.1016/j.rvsc.2006.03.007
bibo:pmid	16730762
has license	els-covid
sha1sum (hex)	f0e555aecc900434e6998bc89a6873049a4e3965
schema:url	https://doi.org/10.1016/j.rvsc.2006.03.007
resource representing a document's title	Oral efficacy of Vero cell attenuated porcine epidemic diarrhea virus DR13 strain
has PubMed Central identifier	PMC7111784
has PubMed identifier	16730762
schema:publication	Research in Veterinary Science
resource representing a document's body	covid:f0e555aecc900434e6998bc89a6873049a4e3965#body_text
is schema:about of	named entity 'MORTALITY' named entity 'THEORY' named entity 'INFECTION' named entity 'COMPARED' named entity 'SAFE' named entity 'STRAIN' named entity 'DIFFERENT' named entity 'MARGIN' named entity 'RESULTING FROM' named entity 'VIRULENT' named entity 'WILD-TYPE' named entity 'SOWS' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'MAY BE' named entity 'HIGHLY' named entity 'intramuscularly' named entity 'compared' named entity 'theory' named entity 'infection' named entity 'STRAIN' named entity 'ORAL' covid:arg/f0e555aecc900434e6998bc89a6873049a4e3965 named entity 'DR13' named entity 'EFFICACY' named entity 'LOWER' named entity 'FRAGMENT' named entity 'ORALLY' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'CHALLENGE' named entity 'ORAL VACCINE' named entity 'POLYMORPHISM' named entity 'ORAL' named entity 'ADMINISTERED' named entity 'GROUPS' named entity 'STUDY SUPPORT' named entity 'APPLIED' named entity 'GROUP' named entity 'ATTENUATED' named entity 'VERO CELL' named entity 'MORTALITY RATE' named entity 'RESTRICTION ENZYME' named entity 'USING' named entity 'HIGH' named entity 'PROTECTION' named entity 'LENGTH' named entity 'ATTENUATED' named entity 'SPECIFIC IMMUNITY' named entity 'DR13' named entity 'VIRUS' named entity '2860' named entity 'CELL' named entity 'PARTICULAR' named entity 'INDUCING' named entity 'CONCENTRATION OF' named entity 'TERM' named entity 'IMMUNIZED' named entity 'PREGNANT' named entity 'IGA' named entity 'FINDINGS' named entity 'INVESTIGATED' named entity 'VERO CELL' named entity 'LATE' named entity 'piglets' named entity 'investigated' named entity 'piglets' named entity 'remained' named entity 'findings' named entity 'efficacy' named entity 'attenuated' named entity 'PEDV' named entity 'PEDV' named entity 'virus' named entity 'specific immunity' named entity 'polymorphism'

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