About: Expression Dynamics of Innate Immunity in Influenza Virus-Infected Swine

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Expression Dynamics of Innate Immunity in Influenza Virus-Infected Swine
Creator	Montoya, María Chiapponi, Chiara Uddin, Jasim Córdoba, Lorena Foni, Emanuela Amadori, Massimo Baratelli, Massimiliano Bilato, Dania Martinez, Jorge Martinez-Orellana, Pamela Razzuoli, Elisabetta Perlin, David Cinar, Del Real, Gustavo Martín Del Burgo, Maria Mehmet, Ulas Solórzano4, Alicia
Source	Medline; PMC
abstract	The current circulating swine influenza virus (IV) subtypes in Europe (H1N1, H1N2, and H3N2) are associated with clinical outbreaks of disease. However, we showed that pigs could be susceptible to other IV strains that are able to cross the species barrier. In this work, we extended our investigations into whether different IV strains able to cross the species barrier might give rise to different innate immune responses that could be associated with pathological lesions. For this purpose, we used the same samples collected in a previous study of ours, in which healthy pigs had been infected with a H3N2 Swine IV and four different H3N8 IV strains circulating in different animal species. Pigs had been clinically inspected and four subjects/group were sacrificed at 3, 6, and 21 days post infection. In the present study, all groups but mock exhibited antibody responses to IV nucleoprotein protein. Pulmonary lesions and high-titered viral replication were observed in pigs infected with the swine-adapted virus. Interestingly, pigs infected with avian and seal H3N8 strains also showed moderate lesions and viral replication, whereas equine and canine IVs did not cause overt pathological signs, and replication was barely detectable. Swine IV infection induced interferon (IFN)-alpha and interleukin-6 responses in bronchoalveolar fluids (BALF) at day 3 post infection, as opposed to the other non-swine-adapted virus strains. However, IFN-alpha responses to the swine-adapted virus were not associated with an increase of the local, constitutive expression of IFN-alpha genes. Remarkably, the Equine strain gave rise to a Serum Amyloid A response in BALF despite little if any replication. Each virus strain could be associated with expression of cytokine genes and/or proteins after infection. These responses were observed well beyond the period of virus replication, suggesting a prolonged homeostatic imbalance of the innate immune system.
has issue date	2017-04-21(xsd:dateTime)
bibo:doi	10.3389/fvets.2017.00048
bibo:pmid	28484702
has license	cc-by
sha1sum (hex)	f10e409ed733f8ca5e49e4ebd0482663328f2267
schema:url	https://doi.org/10.3389/fvets.2017.00048
resource representing a document's title	Expression Dynamics of Innate Immunity in Influenza Virus-Infected Swine
has PubMed Central identifier	PMC5399951
has PubMed identifier	28484702
schema:publication	Front Vet Sci
resource representing a document's body	covid:f10e409ed733f8ca5e49e4ebd0482663328f2267#body_text
is schema:about of	named entity 'IFN' named entity 'canine' named entity 'Swine' named entity 'Pigs' named entity 'alpha' named entity 'replication' named entity 'BALF' named entity 'subtypes' named entity 'group' named entity 'immunity' covid:arg/f10e409ed733f8ca5e49e4ebd0482663328f2267 named entity 'expression' named entity 'innate immune system' named entity 'imbalance' named entity 'IVs' named entity 'responses' named entity 'groups' named entity 'serum' named entity 'Amyloid' named entity 'gene' named entity 'lower respiratory tract' named entity 'IFN' named entity 'porcine' named entity 'lungs' named entity '5.8' named entity 'innate immune response' named entity 'infection' named entity 'pig' named entity 'innate immune responses' named entity 'one-way ANOVA' named entity 'mAb' named entity 'isotype' named entity 'virus' named entity 'quantitative real-time PCR' named entity 'non-parametric' named entity 'gene' named entity 'infection' named entity 'viral replication' named entity 'significant difference' named entity 'PAMPs' named entity 'centrifugation' named entity 'virus strain' named entity 'infection' named entity 'embryonated' named entity 'BALF' named entity 'influenza virus' named entity 'swine influenza' named entity 'antigenic' named entity 'pneumonia' named entity 'virus' named entity 'virus replication' named entity 'receptor' named entity 'infection' named entity 'Canine' named entity 'innate immune response' named entity 'IL-8' named entity 'influenza' named entity 'quantitative real-time PCR' named entity 'serum' named entity 'IFNA7' named entity 'cytokine' named entity 'terminal bronchioles' named entity 'CD3+' named entity 'inoculated' named entity 'porcine'

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