About: Pathological and ultrastructural analysis of surgical lung biopsies in patients with swine‐origin influenza type A/H1N1 and acute respiratory failure

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About: Pathological and ultrastructural analysis of surgical lung biopsies in patients with swine‐origin influenza type A/H1N1 and acute respiratory failure Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Pathological and ultrastructural analysis of surgical lung biopsies in patients with swine‐origin influenza type A/H1N1 and acute respiratory failure
Creator	Ximenes, Manoel Capelozzi, Vera Parra, Edwin Bammann, Ricardo Barbas, Valente Duarte, Duarte, Seixas Er, Parra Irmd, Marid Rh, Barbas Silvia, Carmen Sv, Vl, Capelozzi Ximenesm, Bammann
source	PMC
abstract	BACKGROUND: Cases of H1N1 and other pulmonary infections evolve to acute respiratory failure and death when co‐infections or lung injury predominate over the immune response, thus requiring early diagnosis to improve treatment. OBJECTIVE: To perform a detailed histopathological analysis of the open lung biopsy specimens from five patients with ARDS with confirmed H1N1. METHODS: Lung specimens underwent microbiologic analysis, and examination by optical and electron microscopy. Immunophenotyping was used to characterize macrophages, natural killer, T and B cells, and expression of cytokines and iNOS. RESULTS: The pathological features observed were necrotizing bronchiolitis, diffuse alveolar damage, alveolar hemorrhage and abnormal immune response. Ultrastructural analysis showed viral‐like particles in all cases. CONCLUSIONS: Viral‐like particles can be successfully demonstrated in lung tissue by ultrastructural examination, without confirmation of the virus by RT‐PCR on nasopharyngeal aspirates. Bronchioles and epithelium, rather than endothelium, are probably the primary target of infection, and diffuse alveolar damage the consequence of the effect of airways obliteration and dysfunction on innate immunity, suggesting that treatment should be focused on epithelial repair.
has issue date	2010-12-01(xsd:dateTime)
bibo:doi	10.1590/s1807-59322010001200003
bibo:pmid	21340209
has license	cc-by-nc
sha1sum (hex)	f12dac6dd672f51fbf89bec56df7f7a8af5331df
schema:url	https://doi.org/10.1590/s1807-59322010001200003
resource representing a document's title	Pathological and ultrastructural analysis of surgical lung biopsies in patients with swine‐origin influenza type A/H1N1 and acute respiratory failure
has PubMed Central identifier	PMC3020331
has PubMed identifier	21340209
schema:publication	Clinics (Sao Paulo)
resource representing a document's body	covid:f12dac6dd672f51fbf89bec56df7f7a8af5331df#body_text
is schema:about of	named entity 'TREATMENT' named entity 'BACKGROUND' named entity 'EARLY DIAGNOSIS' named entity 'ultrastructural' covid:arg/f12dac6dd672f51fbf89bec56df7f7a8af5331df named entity 'PATIENTS' named entity 'CASES' named entity 'BIOPSIES' named entity 'DEATH' named entity 'EVOLVE' named entity 'ANALYSIS' named entity 'INFLUENZA TYPE A' named entity 'SWINE' named entity 'ACUTE RESPIRATORY FAILURE' named entity 'IMMUNE RESPONSE' named entity 'PREDOMINATE' named entity 'PULMONARY INFECTIONS' named entity 'LUNG' named entity 'ORIGIN' named entity 'CO-INFECTIONS' named entity 'PATHOLOGICAL' named entity 'SURGICAL' named entity 'H1N1' named entity 'LUNG INJURY' named entity 'ACUTE RESPIRATORY FAILURE' named entity 'acute respiratory failure' named entity 'Pathological' named entity 'H1N1' named entity 'A/H1N1' named entity 'chest x-ray' named entity 'TNFa' named entity 'antibodies' named entity 'shortness of breath' named entity 'H1N1' named entity 'electron microscope' named entity 'necrosis' named entity 'CD1a' named entity 'H1N1' named entity 'bronchiolar' named entity 'macrophages' named entity 'tumor necrosis factor alpha' named entity 'S-OIV' named entity 'basement membrane' named entity 'evolution' named entity 'sloughing' named entity 'virus' named entity 'virus' named entity 'influenza virus' named entity 'IL-4' named entity 'hyaline' named entity 'ARF' named entity 'iNOS' named entity 'alveolar septa' named entity 'lungs' named entity 'immune mechanisms' named entity 'dehydrated' named entity 'histochemical staining' named entity 'macrophages' named entity 'virus' named entity 'exudation' named entity 'AECs' named entity 'Lung Injury' named entity 'cell types' named entity 'lung tissue' named entity 'virus' named entity 'iNOS' named entity 'macrophages' named entity 'nuclei'

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