About: Immune response and onset of protection from Bovine viral diarrhea virus 2 infection induced by modified-live virus vaccination concurrent with injectable trace minerals administration in newly received beef calves

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About: Immune response and onset of protection from Bovine viral diarrhea virus 2 infection induced by modified-live virus vaccination concurrent with injectable trace minerals administration in newly received beef calves Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Immune response and onset of protection from Bovine viral diarrhea virus 2 infection induced by modified-live virus vaccination concurrent with injectable trace minerals administration in newly received beef calves
Creator	Sanchez, Susan Hurley, David Saliki, Jeremiah Palomares, Roberto Adkins, Morgan Bittar, João Hamrick, Brianna Hoyos-Jaramillo, Alejandro Lauber, Kelsey Norton, Natalie Rodriguez, Adriana Stoskute, Agne
Source	Elsevier; Medline; PMC
abstract	Abstract Strategies to improve the onset of protective immunity induced by vaccination against respiratory pathogens may have a significant impact on health of newly received beef calves. The objective was to determine if the use of injectable trace minerals (ITM; Se, Zn, Cu, and Mn) concurrent with a modified-live virus (MLV) vaccine enhances the immune response and onset of protection in beef calves challenged with BVDV2 five days after vaccination. Forty-five calves were randomly assigned to one of three groups (15/group): VAC + ITM, received MLV-vaccine and ITM (Multimin®90) subcutaneously (SC); VAC + SAL, received the same vaccine and saline SC; or UNVAC, unvaccinated. Five days after vaccination (d.0), calves were challenged with BVDV2 strain 890. Health status was evaluated and blood samples were collected for leukocyte counts, BVDV1 and 2 serum neutralizing antibody (SNA), BVDV-PCR, percentage of CD4+, CD8+, WC1+ and CD25+ T-cells. VAC + ITM had lower health scores than UNVAC (d.8 and 9). VAC + ITM had higher BVDV1 & 2 SNA titers than VAC + SAL and UNVAC on d.21 and 28. Lymphocyte counts decreased in UNVAC but not in VAC + ITM or VAC + SAL (d.3 to 11). CD4+ T-cells significantly decreased in UNVAC and VAC + SAL (d.3). VAC + ITM had higher percentage of CD4+ cells than UNVAC (d.3 and 7). VAC + ITM had lower percentage of activated CD4+ and CD8+ than UNVAC (d.7). In summary, vaccination induced a rapid protection against BVDV2 infection. Administration of ITM was associated with increased SNA response to BVDV1 & 2, enhanced health status, mitigation of CD4+ T-cells decreased, and reduction of T-cell activation in calves challenged with BVDV2 five days after immunization. These results support the strategic use of ITM concurrent with vaccination, especially when a rapid protection is needed in newly received beef calves.
has issue date	2020-04-27(xsd:dateTime)
bibo:doi	10.1016/j.vetimm.2020.110055
bibo:pmid	32438245
has license	els-covid
sha1sum (hex)	f17c5ceaf1cfe617fcc028da408d0253df388cb7
schema:url	https://doi.org/10.1016/j.vetimm.2020.110055
resource representing a document's title	Immune response and onset of protection from Bovine viral diarrhea virus 2 infection induced by modified-live virus vaccination concurrent with injectable trace minerals administration in newly received beef calves
has PubMed Central identifier	PMC7184996
has PubMed identifier	32438245
schema:publication	Vet Immunol Immunopathol
resource representing a document's body	covid:f17c5ceaf1cfe617fcc028da408d0253df388cb7#body_text
is schema:about of	named entity 'CD25' named entity 'ITM' named entity 'unvaccinated' named entity 'scores' named entity 'beef calves' named entity 'received' covid:arg/f17c5ceaf1cfe617fcc028da408d0253df388cb7 named entity 'Health' named entity 'health' named entity 'received' named entity 'ITM' named entity 'VAC' named entity 'neutralizing antibody' named entity 'leukocyte' named entity 'respiratory' named entity 'MLV' named entity 'vaccination' named entity 'virus' named entity 'injectable' named entity 'trace minerals' named entity 'modified-live' named entity 'virus' named entity 'injectable' named entity 'modified-live' named entity 'injectable' named entity 'beef calves' named entity 'selenium' named entity 'nasal swab' named entity 'BVDV' named entity 'TCID50' named entity 'beef calves' named entity 'vaccination' named entity 'biopsies' named entity 'University of Wisconsin' named entity 'humoral immune response' named entity 'health status' named entity 'BVDV' named entity 'neutralizing antibodies' named entity 'vaccine' named entity 'immune response' named entity 'cytopathic effects' named entity 'blood samples' named entity 'cannula' named entity 'ad libitum' named entity 'T-cell' named entity 'cattle' named entity 'pathogens' named entity 'FACS' named entity 'zinc' named entity 'feedlots' named entity 'immune response' named entity 'titer' named entity 'Gunma' named entity 'feedlot' named entity 'BVDV' named entity 'CD8' named entity 'blood samples' named entity 'reverse transcribed' named entity 'disease transmission' named entity 'jugular vein' named entity 'CD4' named entity 'antibodies' named entity 'inoculum' named entity 'BVDV' named entity 'microcentrifuge tubes' named entity 'viremia' named entity 'leukocyte' named entity 'serum' named entity 'CD25' named entity 'BVDV'

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