About: Concomitant new diagnosis of systemic lupus erythematosus and COVID-19 with possible antiphospholipid syndrome. Just a coincidence? A case report and review of intertwining pathophysiology

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About: Concomitant new diagnosis of systemic lupus erythematosus and COVID-19 with possible antiphospholipid syndrome. Just a coincidence? A case report and review of intertwining pathophysiology Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Concomitant new diagnosis of systemic lupus erythematosus and COVID-19 with possible antiphospholipid syndrome. Just a coincidence? A case report and review of intertwining pathophysiology
Creator	Cardoso, Eduardo Feterman, Dominique Hundal, Jasmin Magaldi, John
source	Medline; PMC
abstract	In the midst of the COVID-19 pandemic, further understanding of its complications points towards dysregulated immune response as a major component. Systemic lupus erythematosus (SLE) is also a disease of immune dysregulation leading to multisystem compromise. We present a case of new-onset SLE concomitantly with COVID-19 and development of antiphospholipid antibodies. An 18-year-old female that presented with hemodynamic collapse and respiratory failure, progressed to cardiac arrest, and had a pericardial tamponade drained. She then progressed to severe acute respiratory distress syndrome, severe ventricular dysfunction, and worsening renal function with proteinuria and hematuria. Further studies showed bilateral pleural effusions, positive antinuclear and antidouble-stranded DNA antibodies, lupus anticoagulant, and anticardiolipin B. C3 and C4 levels were low. SARS-Cov-2 PCR was positive after 2 negative tests. She also developed multiple deep venous thrombosis, in the setting of positive antiphospholipid antibodies and lupus anticoagulant. In terms of pathophysiology, COVID-19 is believed to cause a dysregulated cytokine response which could potentially be exacerbated by the shift in Th1 to Th2 response seen in SLE. Also, it is well documented that viral infections are an environmental factor that contributes to the development of autoimmunity; however, COVID-19 is a new entity, and it is not known if it could trigger autoimmune conditions. Additionally, it is possible that SARS-CoV-2, as it happens with other viruses, might lead to the formation of antiphospholipid antibodies, potentially contributing to the increased rates of thrombosis seen in COVID-19.
has issue date	2020-07-28(xsd:dateTime)
bibo:doi	10.1007/s10067-020-05310-1
bibo:pmid	32720260
has license	no-cc
sha1sum (hex)	f192d792ed796bb3465499e47aed816a93c1c368
schema:url	https://doi.org/10.1007/s10067-020-05310-1
resource representing a document's title	Concomitant new diagnosis of systemic lupus erythematosus and COVID-19 with possible antiphospholipid syndrome. Just a coincidence? A case report and review of intertwining pathophysiology
has PubMed Central identifier	PMC7384868
has PubMed identifier	32720260
schema:publication	Clin Rheumatol
resource representing a document's body	covid:f192d792ed796bb3465499e47aed816a93c1c368#body_text
is schema:about of	named entity 'negative' named entity 'antibodies' named entity 'leading' named entity 'progressed' named entity 'response' named entity 'lupus' named entity 'hemodynamic' named entity 'antiphospholipid syndrome' named entity 'A MAJOR' named entity 'IMMUNE DYSREGULATION' named entity 'ENTITY' named entity 'STUDIES' named entity 'THROMBOSIS' named entity 'SHIFT' named entity 'HEMATURIA' named entity 'IMMUNE RESPONSE' named entity 'COVID-19' named entity 'CASE REPORT' named entity 'PATHOPHYSIOLOGY' covid:arg/f192d792ed796bb3465499e47aed816a93c1c368 named entity 'studies' named entity 'viruses' named entity 'entity' named entity 'SLE' named entity 'renal function' named entity 'presented' named entity 'positive' named entity 'antiphospholipid antibodies' named entity 'levels' named entity 'pericardial tamponade' named entity 'PCR' named entity 'COVID' named entity 'antibodies' named entity 'antiphospholipid antibodies' named entity 'pleural effusions' named entity 'SLE' named entity 'viral infections' named entity 'antiphospholipid antibodies' named entity 'SLE' named entity 'viruses' named entity 'COVID-19' named entity 'renal function' named entity 'cytokine' named entity 'Th2' named entity 'Systemic lupus erythematosus' named entity 'serum creatinine' named entity 'FiO2' named entity 'Th2 response' named entity 'hypercoagulability' named entity 'environmental triggers' named entity 'respiratory symptoms' named entity 'COVID-19' named entity 'Plaquenil' named entity 'ARDS' named entity 'PCR' named entity 'cytokine release syndrome' named entity 'hypokinesis' named entity 'SLE' named entity 'LVEF' named entity 'apoptotic' named entity 'DVTs' named entity 'COVID' named entity 'antiphospholipid antibodies' named entity 'acute respiratory distress syndrome' named entity 'tachypneic' named entity 'thrombocytopenia' named entity 'pleural effusions' named entity 'DIC' named entity 'SARS-CoV-2' named entity 'SLE' named entity 'molecular mimicry' named entity 'SARS-CoV-2' named entity 'pronation' named entity 'COVID-19' named entity 'IFN-gamma' named entity 'PCR' named entity 'TNF alpha' named entity 'COVID-19'

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