About: In Vitro Inhibition of SARS-CoV-2 Infection by Bovine Lactoferrin

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	In Vitro Inhibition of SARS-CoV-2 Infection by Bovine Lactoferrin
Creator	Siqueira, Marilda Caetano, Braulia Gonçalves, Rafael Bom, Ano Carlos, Alberto Dinis, Ana Melgaço, Juliana Augusto, Matheus Azamor Da Costa Barros, Tamiris Barros, Caroline Cristina Da Costa Neves, Patrícia Da, Aline De Almeida, Patricio Marques De Carvalho, Marques Vieira Da Silva, Andréa Matos, Rocha Missailidis, Sotiris Pedro De Sousa Junior, Ivanildo Pereira Da Costa Campos, Samir Rocha, Vanessa Rodrigues Geraldino, Barbara
Source	BioRxiv
abstract	Since its emergence in late 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been posing a serious threat to public health worldwide as the causative agent of coronavirus disease 2019 (COVID-19). Now distributed in a pandemic pattern, this disease still lacks an effective drug treatment with low toxicity, leading pharmaceutical companies and research labs to work against time to find a candidate molecule to efficiently treat the affected patients. Due to the well-known broad-spectrum antimicrobial activity of the lactoferrin protein, we sought to verify whether its bovine form (bLf) would also be effective in vitro against SARS-CoV-2. Using an antiviral assay based on quantitative reverse transcription-polymerase chain reaction (qRT-PCR), we found that bLf reduced progeny virus yield by up to ∼84,6% in African green monkey kidney epithelial cells (Vero E6) and ∼68,6% in adenocarcinomic human alveolar basal epithelial cells (A549) at 1 mg/mL, a concentration previously shown to have low cytotoxicity. Therefore, our preliminary data suggest that bLf has the potential to constitute a biochemical approach to fight the new coronavirus pandemic.
has issue date	2020-05-13(xsd:dateTime)
bibo:doi	10.1101/2020.05.13.093781
has license	biorxiv
sha1sum (hex)	f1a7d3fc30fe58ca0c5e21c8a400a0f4c5f8d2e7
schema:url	https://doi.org/10.1101/2020.05.13.093781
resource representing a document's title	In Vitro Inhibition of SARS-CoV-2 Infection by Bovine Lactoferrin
schema:publication	bioRxiv
resource representing a document's body	covid:f1a7d3fc30fe58ca0c5e21c8a400a0f4c5f8d2e7#body_text
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