About: Protective and pathological immunity during CNS infections

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Protective and pathological immunity during CNS infections
Creator	Hunter, Christopher Klein, Robyn
Source	Elsevier; Medline; PMC
abstract	The concept of immune privilege of the central nervous system (CNS) has dominated the study of inflammatory processes in the brain. However, clinically relevant models have highlighted the innate pathways that limit pathogen invasion of the CNS and that adaptive immunity mediates control of many neural infections. Because protective responses can result in bystander damage there are regulatory mechanisms that balance protective and pathological inflammation but which may also allow microbial persistence. The focus of this review is to consider the host-pathogen interactions that influence neurotropic infections and to highlight advances in understanding of innate and adaptive mechanisms of resistance as key determinants of the outcome of CNS infection. Advances in these areas have broadened our comprehension of how the immune system functions in the brain and can readily overcome immune privilege.
has issue date	2017-06-01(xsd:dateTime)
bibo:doi	10.1016/j.immuni.2017.06.012
bibo:pmid	28636958
has license	hybrid-oa
sha1sum (hex)	f1bc4ef86fedbffa0c0ddd1e467e0d1e4ad3a7f9
schema:url	https://doi.org/10.1016/j.immuni.2017.06.012
resource representing a document's title	Protective and pathological immunity during CNS infections
has PubMed Central identifier	PMC5662000
has PubMed identifier	28636958
schema:publication	Immunity
resource representing a document's body	covid:f1bc4ef86fedbffa0c0ddd1e467e0d1e4ad3a7f9#body_text
is schema:about of	named entity 'IMMUNITY' named entity 'PATHOLOGICAL' named entity 'CENTRAL NERVOUS SYSTEM INFECTIONS' named entity 'Pathological' named entity 'Central Nervous System Infections' named entity 'Trojan Horse' named entity 'inflammation' named entity 'peptide' named entity 'CNS' named entity 'transactivator' named entity 'type I IFN' named entity 'CD8 +' named entity 'astrocytes' named entity 'NVU' named entity 'neuron' named entity 'axonal regeneration' named entity 'infection' named entity 'neurons' named entity 'broad-spectrum antibiotic' named entity 'microbial' named entity 'epithelial' named entity 'intracellular parasites' named entity 'HSV' named entity 'immune privilege' named entity 'type I IFNs' named entity 'monocyte' named entity 'treatment options' named entity 'Treg cells' named entity 'long-lived' named entity 'forebrain' named entity 'neutrophils' named entity 'dendritic cells' named entity 'immune privileged' named entity 'LAG3' named entity 'cell cycle' named entity 'CNS' named entity 'clinically relevant' named entity 'monocyte' named entity 'infection' named entity 'neurological function' named entity 'astrocytes' named entity 'optic nerve' named entity 'parasite control' named entity 'BBB' named entity 'mice' named entity 'microglia' named entity 'lymphatics' named entity 'monocytes' named entity 'immunopathology' named entity 'CNS' named entity 'cognition' named entity 'microglial' named entity 'autoimmune encephalitides' named entity 'CD8 +' named entity 'CD4 +' named entity 'microglia' named entity 'M. tuberculosis' named entity 'CNS' named entity 'pathogen associated molecular patterns' named entity 'toxoplasmosis' named entity 'natural host' named entity 'ulcerative colitis' named entity 'perivascular' named entity 'CNS' named entity 'cell type' named entity 'chronic phase' named entity 'virus' named entity 'Microglia' named entity 'BBB' named entity 'IL-17' named entity 'microglial' named entity 'CNS' named entity 'brain microvascular' named entity 'seizures' named entity 'Protein' named entity 'neurotropic' named entity 'CD8 +' named entity 'immune response' named entity 'anti-fungal' named entity 'infection'

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