About: Validation of a digital pathology system including remote review during the COVID-19 pandemic

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About: Validation of a digital pathology system including remote review during the COVID-19 pandemic Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Validation of a digital pathology system including remote review during the COVID-19 pandemic
Creator	Lee, • Tan, K Kim, • Xu, • Ardon, Orly Busam, Klaus Corsale, Lorraine Ellenson, Lora England, Christine Friedlander, Maria Hameed, Meera Hanna, Matthew Klimstra, David Reuter, Victor Sauter, Jennifer Schüffler, Peter Stamelos, Evangelos Tang, Laura Agaram, P Brogi, • Labasin, • Narasimhan, • Ntiamoah, • Philip, • Sahussapont, • Sirintrapun, Joseph Tejus Bale, •
topic	covid:f1c63715b86dd4354d1ce848b63aa4b7c809579e#this
Source	Medline; PMC
abstract	Remote digital pathology allows healthcare systems to maintain pathology operations during public health emergencies. Existing Clinical Laboratory Improvement Amendments regulations require pathologists to electronically verify patient reports from a certified facility. During the 2019 pandemic of COVID-19 disease, caused by the SAR-CoV-2 virus, this requirement potentially exposes pathologists, their colleagues, and household members to the risk of becoming infected. Relaxation of government enforcement of this regulation allows pathologists to review and report pathology specimens from a remote, non-CLIA certified facility. The availability of digital pathology systems can facilitate remote microscopic diagnosis, although formal comprehensive (case-based) validation of remote digital diagnosis has not been reported. All glass slides representing routine clinical signout workload in surgical pathology subspecialties at Memorial Sloan Kettering Cancer Center were scanned on an Aperio GT450 at ×40 equivalent resolution (0.26 µm/pixel). Twelve pathologists from nine surgical pathology subspecialties remotely reviewed and reported complete pathology cases using a digital pathology system from a non-CLIA certified facility through a secure connection. Whole slide images were integrated to and launched within the laboratory information system to a custom vendor-agnostic, whole slide image viewer. Remote signouts utilized consumer-grade computers and monitors (monitor size, 13.3–42 in.; resolution, 1280 × 800–3840 × 2160 pixels) connecting to an institution clinical workstation via secure virtual private network. Pathologists subsequently reviewed all corresponding glass slides using a light microscope within the CLIA-certified department. Intraobserver concordance metrics included reporting elements of top-line diagnosis, margin status, lymphovascular and/or perineural invasion, pathology stage, and ancillary testing. The median whole slide image file size was 1.3 GB; scan time/slide averaged 90 s; and scanned tissue area averaged 612 mm(2). Signout sessions included a total of 108 cases, comprised of 254 individual parts and 1196 slides. Major diagnostic equivalency was 100% between digital and glass slide diagnoses; and overall concordance was 98.8% (251/254). This study reports validation of primary diagnostic review and reporting of complete pathology cases from a remote site during a public health emergency. Our experience shows high (100%) intraobserver digital to glass slide major diagnostic concordance when reporting from a remote site. This randomized, prospective study successfully validated remote use of a digital pathology system including operational feasibility supporting remote review and reporting of pathology specimens, and evaluation of remote access performance and usability for remote signout.
has issue date	2020-06-22(xsd:dateTime)
bibo:doi	10.1038/s41379-020-0601-5
bibo:pmid	32572154
has license	no-cc
sha1sum (hex)	f1c63715b86dd4354d1ce848b63aa4b7c809579e
schema:url	https://doi.org/10.1038/s41379-020-0601-5
resource representing a document's title	Validation of a digital pathology system including remote review during the COVID-19 pandemic
has PubMed Central identifier	PMC7306935
has PubMed identifier	32572154
schema:publication	Mod Pathol
resource representing a document's body	covid:f1c63715b86dd4354d1ce848b63aa4b7c809579e#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/f1c63715b86dd4354d1ce848b63aa4b7c809579e
is schema:about of	named entity 'pathology' named entity 'area' named entity 'case-based' named entity 'size' named entity 'pathology' named entity 'images' named entity 'diagnosis' named entity 'primary' named entity 'digital pathology' named entity 'surgical pathology' named entity 'Our' named entity 'complete' named entity 'image' named entity 'This' named entity 'concordance' named entity 'slide' named entity 'During' named entity '800' named entity 'PRIVATE' named entity 'AREA' named entity 'EXPERIENCE' named entity '2019' named entity 'LIGHT MICROSCOPE' named entity 'PARTS' named entity 'FORMAL' named entity 'VIRUS' named entity 'SECURE' named entity 'REGULATION' named entity 'DIAGNOSES' named entity 'INFECTED' named entity 'CONSUMER' named entity 'REPORTING' named entity 'TO MAINTAIN' named entity 'AVAILABILITY OF' named entity 'RELAXATION' named entity 'HEALTHCARE SYSTEMS' named entity 'USING' named entity 'EMERGENCIES' named entity 'ALLOWS' named entity 'REVIEW' named entity 'ROUTINE' named entity 'PANDEMIC' named entity 'CANCER CENTER' named entity '3840' named entity 'ENFORCEMENT' named entity 'PATIENT REPORTS' named entity 'SLIDES' named entity '100%' named entity 'TIME' named entity 'VENDOR' named entity 'MEMORIAL' named entity 'SCAN' named entity 'KETTERING'

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