About: Transplantation of highly purified peripheral blood CD34(+) cells from HLA-mismatched parental donors in 14 children: evaluation of early monitoring of engraftment

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About: Transplantation of highly purified peripheral blood CD34(+) cells from HLA-mismatched parental donors in 14 children: evaluation of early monitoring of engraftment Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Transplantation of highly purified peripheral blood CD34(+) cells from HLA-mismatched parental donors in 14 children: evaluation of early monitoring of engraftment
Creator	Peters, C Lion, T Handgretinger, R Gadner, H Klingebiel, T Dieckmann, K Fischer, G Fritsch, G Holter, W Hö Cker, P Matthes-Martin, S Witt, V
source	PMC
abstract	HLA-mismatched family members may represent an important cell source for patients that require stem cell transplantation but lack both a matched sibling donor and a closely matched unrelated donor. We report the outcome of 19 transplantations from HLA two- or three- loci mismatched parental donors in which 14 pediatric patients with hematological malignancies or other disorders, received a median of 21.5 × 10(6) (range, 5.4–58) highly purified CD34(+)peripheral blood stem cells (PBSC), as well as 4.7 × 10(4) (range, 0.4–12) donor T cells per kg body weight. T cell depletion was performed using a two-step CD34-positive selection on two different magnetic beads devices. Ten of 14 patients presented with rapid myeloid engraftment. The four patients who presented with graft failure (two non-engraftments, two rejections) received a second stem cell graft and one a third. Graft rejection was detected early by polymerase chain reaction (PCR) analysis of FACS-sorted T cells. Eight of the 14 patients are still alive after a median observation period of 15.6 months (range, 3–31.3) with full donor chimerism in all hematopoietic cell lineages. No acute organ graft-versus-host disease (GVHD) and no chronic GVHD have occurred. One patient experienced relapse of leukemia. We conclude that transplantation of allogeneic PBSC from haploidentical donors will open new perspectives for pediatric patients for whom an HLA-matched stem cell graft is not available. Close monitoring of recipient and donor hematopoiesis might be of clinical value, to recognize early engraftment or rejection.
has issue date	1999-12-02(xsd:dateTime)
bibo:doi	10.1038/sj.leu.2401577
bibo:pmid	10602431
has license	no-cc
sha1sum (hex)	f1eb9a86ad8c5e185ed4147d33b3964a717e10f0
schema:url	https://doi.org/10.1038/sj.leu.2401577
resource representing a document's title	Transplantation of highly purified peripheral blood CD34(+) cells from HLA-mismatched parental donors in 14 children: evaluation of early monitoring of engraftment
has PubMed Central identifier	PMC7101968
has PubMed identifier	10602431
schema:publication	Leukemia
resource representing a document's body	covid:f1eb9a86ad8c5e185ed4147d33b3964a717e10f0#body_text
is schema:about of	named entity 'presented' named entity 'patients' named entity 'CD34' named entity 'Ten' named entity 'highly' named entity 'rapid' named entity '4.7' named entity 'PBSC' named entity 'loci' named entity '5.4' named entity 'myeloid' named entity 'PBSC' named entity 'Netherlands' named entity 'CMV' named entity 'acute lymphoblastic leukemia' named entity 'myelopoiesis' named entity 'viremia' named entity 'parainfluenza' named entity 'HLA loci' named entity 'PCR analysis' named entity 'aplasia' named entity 'OKT3' named entity 'GVHD' named entity 'chronic graft-versus-host disease' named entity 'Blood samples' named entity 'allogeneic stem cell transplantation' named entity 'reticulocytes' named entity 'prednisone' named entity 'Animal studies' named entity 'alleles' named entity 'relapse' named entity 'Lyon' named entity 'PCR' named entity 'leukemia' named entity 'conditioning regimen' named entity 'prophylactic measure' named entity 'thymidine' named entity 'long-lasting' named entity 'stem cell' named entity 'remission' named entity 'HLA-A' named entity 'HLA' named entity 'DLI' named entity 'enteral nutrition' named entity 'EBV' named entity 'stem cell' named entity 'intensive care unit' named entity 'stem cell' named entity 'thymic' named entity 'melphalan' named entity 'sepsis' named entity 'microtiter' named entity 'side-effects' named entity 'nucleated cells' named entity 'prophylactically' named entity 'stem cell' named entity 'myeloablative' named entity 'Hickman line' named entity 'IL-2' named entity 'GVHD' named entity 'recombinant' named entity 'staining' named entity 'HLA loci' named entity 'HLA-B' named entity 'growth factors' named entity 'multiple organ failure' named entity 'lung transplantation' named entity 'relapse' named entity 'Thousand Oaks' named entity 'body weight'

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