About: Discovery of a new antiviral protein isolated Lonomia obliqua analysed by bioinformatics and real-time approaches

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About: Discovery of a new antiviral protein isolated Lonomia obliqua analysed by bioinformatics and real-time approaches Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Discovery of a new antiviral protein isolated Lonomia obliqua analysed by bioinformatics and real-time approaches
Creator	Rahal, Paula Carmo, Viegas Carolina, Ana Cristina, Yamasaki Curti, Pires Fabiana, • Figueiredo, Adelaide Giovanni, Silva Isabel De Oliveira, Maria Lilian, • Mendonça, Zucatelli Nogueira, Dalton Pereira, Cristina Ronaldo, • Suely, Santos Tomanari, Hiromi
source	Medline; PMC
abstract	This study presents a new recombinant protein that acts as a powerful antiviral (rAVLO—recombinant Antiviral protein of Lonomia obliqua). It was able to reduce the replication by 10(6) fold for herpes virus and by 10(4) fold for rubella virus. RT-PCR of viral RNA rAVLO treated infected cells also showed similar rate of inhibition in replication. The analysis of this protein by bioinformatics suggests that this protein is globular, secreted with a signal peptide and has the ability to bind to MHC class I. It was found that there are several protein binding sites with various HLA and a prevalence of α-helices in the N-terminal region (overall classified as a α/β protein type). BLAST similarity sequence search for corresponding cDNA did not reveal a similar sequence in Genbank, suggesting that it is from a novel protein family. In this study we have observed that this recombinant protein and hemolymph has a potent antiviral action. This protein was produced in a baculovirus/Sf-9 system. Therefore, these analyses suggest that this novel polypeptide is a candidate as a broad spectrum antiviral.
has issue date	2014-06-08(xsd:dateTime)
bibo:doi	10.1007/s10616-014-9740-1
bibo:pmid	24908059
has license	green-oa
sha1sum (hex)	f1fc7cb8748511840057d2785ccba62dd8bac8df
schema:url	https://doi.org/10.1007/s10616-014-9740-1
resource representing a document's title	Discovery of a new antiviral protein isolated Lonomia obliqua analysed by bioinformatics and real-time approaches
has PubMed Central identifier	PMC4628924
has PubMed identifier	24908059
schema:publication	Cytotechnology
resource representing a document's body	covid:f1fc7cb8748511840057d2785ccba62dd8bac8df#body_text
is schema:about of	named entity 'BIOINFORMATICS' named entity 'rubella virus' named entity 'binding sites' named entity 'protein' named entity 'RNA' named entity 'THESE' named entity 'CDNA' named entity 'STUDY' named entity 'DISCOVERY' named entity 'PRESENTS' named entity 'N-TERMINAL ' named entity 'RECOMBINANT PROTEIN' named entity 'TO BIND TO' named entity 'NOVEL PROTEIN' named entity 'POLYPEPTIDE' named entity 'SYSTEM' named entity 'ANALYSIS' named entity 'BIOINFORMATICS' named entity 'POWERFUL' named entity 'RUBELLA VIRUS' named entity 'SIMILARITY' named entity 'HAVE' named entity 'REPLICATION' named entity 'ISOLATED' named entity 'FOUND' named entity 'INFECTED' named entity 'RATE' named entity 'INHIBITION' named entity 'APPROACHES' named entity 'TYPE' named entity 'SEQUENCE SEARCH' named entity 'PROTEIN BINDING SITES' named entity 'DID' named entity 'ANTIVIRAL' named entity 'REAL-TIME' named entity 'LONOMIA OBLIQUA' named entity 'NEW' named entity 'LONOMIA OBLIQUA' named entity 'REGION' named entity 'BROAD SPECTRUM' named entity 'HEMOLYMPH' named entity 'CLASSIFIED' named entity 'TREATED' named entity 'GLOBULAR' named entity 'HELICES' named entity 'MHC CLASS I' named entity 'RT-PCR' named entity 'FOLD' named entity 'PREVALENCE' named entity 'SUGGEST' named entity 'VIRAL RNA' named entity 'SEQUENCE' named entity 'CELLS' named entity 'BACULOVIRUS' named entity 'GENBANK' named entity 'HLA' named entity 'SIMILAR' named entity '2FB' named entity 'PROTEIN FAMILY' named entity 'OBSERVED' named entity 'CANDIDATE' named entity 'PROTEIN ' named entity 'TO REDUCE' named entity 'ANTIVIRAL' named entity 'IS A' named entity 'NEW'

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