About: Genomic epidemiology reveals multiple introductions and spread of SARS-CoV-2 in the Indian state of Karnataka

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About: Genomic epidemiology reveals multiple introductions and spread of SARS-CoV-2 in the Indian state of Karnataka Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Genomic epidemiology reveals multiple introductions and spread of SARS-CoV-2 in the Indian state of Karnataka
Creator	Desai, Anita Reddy, Vijayalakshmi Vasanthapuram, Ravi Mani, Reeta Hameed, Shahul Habib, Farhat Kumar, Prakash Damodar, Tina Dinesh, Prameela George, Anson Hosallimath, Kiran John, Banerjee Kumar, Narendra Pattabiraman, Chitra Pattanaik, Amrita Pk, Harsha Rasheed, Risha Reddy, Kiran Venkataswamy, Manjunatha Vijay, Nakka
topic	covid:f20a18ec15a01d1d19dd8baa349831d48924c9ff#this
Source	MedRxiv
abstract	Karnataka, a state in south India, reported its first case of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) on March 8, 2020, more than a month after the first case was reported in India. We used a combination of contact tracing and genomic epidemiology to trace the spread of SARS-CoV-2 in the state up until May 21, 2020 (1578 cases). We obtained 47 full genomes of SARS-CoV-2 which clustered into six lineages (Pangolin lineages-A, B, B.1, B.1.1, B.4, and B.6). The lineages in Karnataka were known to be circulating in China, Southeast Asia, Iran, Europe and other parts of India and are likely to have been imported into the state both by international and domestic travel. Our sequences grouped into 12 contact clusters and 11 cases with no known contacts. We found nine of the 12 contact clusters had a single lineage of the virus, consistent with multiple introductions and most (8/12) were contained within a single district, consistent with local spread. In most of the twelve clusters, the index case (9/12) and spreaders (8/12) were symptomatic. Of the 47 sequences, 31 belonged to the B/B.6 lineage, including seven of eleven cases with no known contact, this is consistent with the ongoing transmission of this lineage in the state. Genomic epidemiology of SARS-CoV-2 in Karnataka is consistent with multiple introductions of the virus followed by local transmission in parallel with ongoing viral evolution. This is the first study from India combining genomic data with epidemiological information emphasizing the need for an integrated approach to outbreak response.
has issue date	2020-07-11(xsd:dateTime)
bibo:doi	10.1101/2020.07.10.20150045
has license	medrxiv
sha1sum (hex)	f20a18ec15a01d1d19dd8baa349831d48924c9ff
schema:url	https://doi.org/10.1101/2020.07.10.20150045
resource representing a document's title	Genomic epidemiology reveals multiple introductions and spread of SARS-CoV-2 in the Indian state of Karnataka
resource representing a document's body	covid:f20a18ec15a01d1d19dd8baa349831d48924c9ff#body_text
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