About: A “possible” involvement of TNF-alpha in apoptosis induction in peripheral blood lymphocytes of cats with feline infectious peritonitis

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About: A “possible” involvement of TNF-alpha in apoptosis induction in peripheral blood lymphocytes of cats with feline infectious peritonitis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A “possible” involvement of TNF-alpha in apoptosis induction in peripheral blood lymphocytes of cats with feline infectious peritonitis
Creator	Hohdatsu, Tsutomu Koyama, Hiroyuki Takano, Tomomi Hashida, Yoshikiyo Kaneko, Yasuhiro Tanabe, Maki
Source	Elsevier; Medline; PMC
abstract	Feline infectious peritonitis (FIP) cats show a decrease in peripheral blood lymphocyte counts, and a particularly marked decrease in T cells including CD4(+) and CD8(+) cells. In this study, we showed that lymphopenia observed in FIP cats was due to apoptosis, and that the ascitic fluid, plasma, and culture supernatant of peritoneal exudate cells (adherent cells with macrophage morphology, or PEC) from FIP cats readily induced apoptosis in specific pathogen-free cat peripheral blood mononuclear cells, particularly CD8(+) cells. In addition, TNF-alpha released from macrophages and TNF-receptor (TNFR) 1 and TNFR2 mRNA expression in lymphocytes were closely involved in this apoptosis induction. In particular, in CD8(+) cells cultured in the presence of the PEC culture supernatant, the expression levels of TNFR1 and TNFR2 mRNA were increased, indicating that CD8(+) cells are more susceptible to apoptosis induction by TNF-alpha than other lymphocyte subsets, particularly B cells (CD21(+) cells). The results of this study suggest that TNF-alpha, produced by virus-infected macrophages, is responsible for induction of apoptosis in uninfected T cells, primarily CD8(+) T cells.
has issue date	2007-01-31(xsd:dateTime)
bibo:doi	10.1016/j.vetmic.2006.08.033
bibo:pmid	17046178
has license	no-cc
sha1sum (hex)	f21986e5af3d6a65b7e16bd701bec66fe809f2a1
schema:url	https://doi.org/10.1016/j.vetmic.2006.08.033
resource representing a document's title	A “possible” involvement of TNF-alpha in apoptosis induction in peripheral blood lymphocytes of cats with feline infectious peritonitis
has PubMed Central identifier	PMC7117258
has PubMed identifier	17046178
schema:publication	Vet Microbiol
resource representing a document's body	covid:f21986e5af3d6a65b7e16bd701bec66fe809f2a1#body_text
is schema:about of	named entity 'peripheral blood lymphocyte' named entity 'mRNA' named entity 'peritonitis' named entity 'DUE TO' named entity 'EXPRESSION' named entity 'MACROPHAGE' named entity 'ADDITION' covid:arg/f21986e5af3d6a65b7e16bd701bec66fe809f2a1 named entity 'PERIPHERAL BLOOD LYMPHOCYTES' named entity 'OBSERVED' named entity 'RESULTS' named entity 'CD4' named entity 'CULTURE SUPERNATANT' named entity 'TNF-ALPHA' named entity 'DECREASE' named entity 'MRNA' named entity 'SPECIFIC' named entity 'PRESENCE OF' named entity 'LYMPHOCYTES' named entity 'INCREASED' named entity 'INDUCTION OF APOPTOSIS' named entity 'INDICATING' named entity 'APOPTOSIS INDUCTION' named entity 'INVOLVEMENT' named entity 'TNF-ALPHA' named entity 'MRNA EXPRESSION' named entity 'INFECTED' named entity 'CATS' named entity 'FELINE INFECTIOUS PERITONITIS' named entity 'MARKED' named entity 'APOPTOSIS INDUCTION' named entity 'LYMPHOCYTE SUBSETS' named entity 'PARTICULAR' named entity 'PERITONEAL EXUDATE' named entity 'T CELLS' named entity 'LEVELS' named entity 'PATHOGEN' named entity 'SUSCEPTIBLE' named entity 'PERIPHERAL BLOOD LYMPHOCYTE' named entity 'TNFR2' named entity 'LYMPHOCYTE COUNTS' named entity 'INVOLVED' named entity 'UNINFECTED' named entity 'PERIPHERAL BLOOD MONONUCLEAR CELLS' named entity 'CATS' named entity 'MACROPHAGES' named entity 'CELLS' named entity 'PEC' named entity 'VIRUS' named entity 'FIP' named entity 'RECEPTOR' named entity 'STUDY' named entity 'CD8' named entity 'MORPHOLOGY' named entity 'FREE' named entity 'INCLUDING' named entity 'CAT' named entity 'ASCITIC FLUID' named entity 'INDUCED' named entity 'SUGGEST' named entity 'RELEASED' named entity 'B CELLS' named entity 'RESPONSIBLE' named entity 'APOPTOSIS' named entity 'CELLS CULTURED' named entity 'FELINE INFECTIOUS PERITONITIS' named entity 'LYMPHOPENIA' named entity 'TNFR1' named entity 'PLASMA' named entity 'FIP' named entity 'FIP' named entity 'TNFR2' named entity 'cells' named entity 'ascitic fluid' named entity 'induction' named entity 'supernatant'

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