About: Globule leukocytes and mast cells in the rat trachea: their number, distribution, and response to compound 48/80 and dexamethasone

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Globule leukocytes and mast cells in the rat trachea: their number, distribution, and response to compound 48/80 and dexamethasone Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Globule leukocytes and mast cells in the rat trachea: their number, distribution, and response to compound 48/80 and dexamethasone
Creator	Mcdonald, Donald Nadel, Jay Tam, Elizabeth Calonico, Lynne
Source	PMC
abstract	Globule leukocytes in the epithelium of the rat trachea may be counterparts of mucosal mast cells that are located in the gastrointestinal tract. If they are indeed similar to mucosal mast cells, globule leukocytes would be expected to decrease in number in rats treated with dexamethasone but not in rats treated with compound 48/80, an agent which causes non-antigenic degranulation of connective tissue mast cells. In this study, we determined the number and compared the distribution of globule leukocytes and connective tissue mast cells in the tracheas of pathogen-free rats. We then determined whether the number of these two types of cells changes in rats treated for 5 days with compound 48/80, dexamethasone, a combination of compound 48/80 and dexamethasone, or saline. We identified globule leukocytes and mast cells in whole mounts and histological sections of rat tracheas by using a histochemical reaction that demonstrates the chymotrypsin-like protease (chloroacetate esterase) present in mast cell granules. Using this method, we found that aproximately 225000 globule leukocytes were present in the epithelium of the trachea. These cells were most abundant in the rostral trachea. Rats treated with dexamethasone had a 91% reduction in the number of globule leukocytes with protease-containing granules, but rats treated with compound 48/80 had a normal number of these cells. We found some 55000 connective tissue mast cells in the same tracheas. Mast cells were most abundant in the posterior membrane of the caudal trachea and in the lamina propria between cartilaginous rings. Rats treated with compound 48/80 had a 96% reduction in mast cells with protease-containing granules, but rats treated with dexamethasone had a normal complement of mast cells. We conclude that globule leukocytes are abundant in the tracheas of healthy rats, are similar in morphology and pharmacological responses to mucosal mast cells located in other organs of rats, and are more numerous than and have a different distribution than connective tissue mast cells. Globule leukocytes in the tracheal epithelium may have a role in respiratory defenses similar to that of mucosal mast cells in other organs.
has issue date	1988-01-01(xsd:dateTime)
bibo:doi	10.1007/bf02463644
bibo:pmid	3394953
has license	no-cc
sha1sum (hex)	f2459c9408588a7fe1d66ad1e16e317577272c86
schema:url	https://doi.org/10.1007/bf02463644
resource representing a document's title	Globule leukocytes and mast cells in the rat trachea: their number, distribution, and response to compound 48/80 and dexamethasone
has PubMed Central identifier	PMC7087917
has PubMed identifier	3394953
schema:publication	Anat Embryol (Berl)
resource representing a document's body	covid:f2459c9408588a7fe1d66ad1e16e317577272c86#body_text
is schema:about of	named entity 'mast cells' named entity 'dexamethasone' named entity 'reduction' named entity 'degranulation' named entity 'tracheas' named entity 'connective tissue' named entity 'rats' named entity 'globule' named entity 'identified' named entity 'mast cells' named entity 'leukocytes' named entity 'treated' named entity 'mast cells' named entity 'mucosal' named entity 'globule' named entity 'defenses' named entity 'treated' named entity 'compound' named entity 'leukocytes' named entity 'number' named entity 'dexamethasone' named entity 'types' named entity 'gastrointestinal tract' named entity 'compound' named entity 'saline' named entity 'organs' named entity 'number' named entity 'numerous' named entity 'number' named entity 'rat' named entity 'mucosal' named entity 'leukocytes' named entity 'leukocytes' named entity 'Mast cells' named entity 'lamina propria' named entity 'caudal' named entity 'connective tissue' named entity 'antigenic' named entity 'saline' named entity 'tracheas' named entity 'leukocytes' named entity 'rat' named entity 'mast cells' named entity 'mast cells' named entity 'epithelium' named entity 'esterase' named entity 'protease' named entity 'histochemical' named entity 'mast cells' named entity 'mast cells' named entity 'Anatomy' named entity 'mast cells' named entity 'nucleus' named entity 'secretory cell' named entity 'trachea' named entity 'genitourinary' named entity 'room temperature' named entity 'anesthetic' named entity 'mast cells' named entity 'mast cells' named entity 'morphology' named entity 'nucleus' named entity 'tracheal lumen' named entity 'compound 48/80' named entity 'elastomer' named entity 'connective tissue' named entity 'Histological sections' named entity 'Histological sections' named entity 'trachea' named entity 'leukocytes' named entity 'decrease in number' named entity 'cyanosis' named entity 'esterase' named entity 'compound 48/80' named entity 'leukocytes' named entity 'substrate' named entity 'trachea' named entity 'epithelial cells'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software