About: When your cap matters: Structural insights into self vs non-self recognition of 5′ RNA by immunomodulatory host proteins

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About: When your cap matters: Structural insights into self vs non-self recognition of 5′ RNA by immunomodulatory host proteins Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	When your cap matters: Structural insights into self vs non-self recognition of 5′ RNA by immunomodulatory host proteins
Creator	Leung, Daisy Amarasinghe, Gaya
Source	Elsevier; Medline; PMC
abstract	Cytosolic recognition of viral RNA is important for host innate immune responses. Differential recognition of self vs non-self RNA is a considerable challenge as the inability to differentiate may trigger aberrant immune responses. Recent work identified the composition of the RNA 5′, including the 5′ cap and its methylation state, as an important determinant of recognition by the host. Recent studies have advanced our understanding of the modified 5′ RNA recognition and viral antagonism of RNA receptors. Here, we will discuss RIG-I and IFIT proteins as examples of host proteins that detect dsRNA and ssRNA, respectively.
has issue date	2016-02-01(xsd:dateTime)
bibo:doi	10.1016/j.sbi.2016.02.001
bibo:pmid	26916433
has license	hybrid-oa
sha1sum (hex)	f24ffa95b35bfa28164a336db89d61129670d9f3
schema:url	https://doi.org/10.1016/j.sbi.2016.02.001
resource representing a document's title	When your cap matters: Structural insights into self vs non-self recognition of 5′ RNA by immunomodulatory host proteins
has PubMed Central identifier	PMC5218996
has PubMed identifier	26916433
schema:publication	Current Opinion in Structural Biology
resource representing a document's body	covid:f24ffa95b35bfa28164a336db89d61129670d9f3#body_text
is schema:about of	named entity 'host' named entity 'trigger' named entity 'RNA' named entity 'determinant' named entity 'Cytosolic' named entity 'host' named entity 'INSIGHTS' named entity 'HOST' named entity 'MODIFIED' named entity 'RIG-I' named entity 'CHALLENGE' named entity 'DISCUSS' named entity 'INCLUDING' named entity 'IS A' named entity 'NON-SELF' named entity 'SSRNA' named entity 'SELF' named entity 'DETECT' named entity 'IMMUNOMODULATORY' named entity 'STRUCTURAL' named entity 'SELF RECOGNITION' named entity 'COMPOSITION' named entity 'VIRAL RNA' named entity 'PROTEINS' named entity 'CAP' named entity 'RNA' named entity 'STUDIES' named entity 'IDENTIFIED' named entity 'ANTAGONISM' named entity 'ABERRANT' named entity 'CONSIDERABLE' named entity 'METHYLATION' named entity 'PROTEINS' named entity 'IFIT' named entity 'STATE' named entity 'RNA' named entity 'CAP' named entity 'DSRNA' named entity 'HAVE' named entity 'RECOGNITION' named entity 'INABILITY' named entity 'HOST' named entity 'OUR' named entity 'TRIGGER' named entity 'ADVANCED' named entity 'SELF' named entity 'CYTOSOLIC' named entity 'DETERMINANT' named entity 'ITS' named entity 'DIFFERENTIAL' named entity 'IMPORTANT' named entity 'NON-SELF' named entity 'VIRAL' named entity 'HERE' named entity 'IMMUNE RESPONSES' named entity 'WORK' named entity 'DIFFERENTIATE' named entity 'RECEPTORS' named entity 'RECENT' named entity 'UNDERSTANDING' named entity 'RNA' named entity 'RNA' named entity 'insights' named entity 'RNA' named entity 'IFIT proteins' named entity 'viral RNA' named entity 'ssRNA' named entity 'RIG-I' named entity 'proteins' named entity 'host' named entity 'IFIT proteins' named entity 'MAVS' named entity 'TBK' named entity 'RIG-I' named entity 'methylation' named entity 'ATP' named entity 'IFIT2' named entity 'IFN' named entity 'virus' named entity 'RNA'

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