About: Ninety-day inhalation study in rats, comparing smoke from cigarettes that heat tobacco with those that burn tobacco

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About: Ninety-day inhalation study in rats, comparing smoke from cigarettes that heat tobacco with those that burn tobacco Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Ninety-day inhalation study in rats, comparing smoke from cigarettes that heat tobacco with those that burn tobacco
Creator	Sagartz, John Reynolds, R Ayres, Arnold Burger, Gary Burger, J Co, Tobacco C~ggins, Christopherr Wallacehayes, Anda
Source	Elsevier; Medline; PMC
abstract	Abstract Eight groups of 30 male and 30 female rats were exposed 1 hr per day, 5 days per week for 13 weeks, to smoke from reference (tobacco burned) or test (tobacco only heated) cigarettes, at nicotine concentrations of 5, 15, or 30 μg/liter of air. Similar smoke concentrations of wet total particulate matter and carbon monoxide were produced in each of the test/reference comparisons. There was a pronounced depression of minute ventilation of animals in the reference groups, but not in the test animals. Blood carboxyhemoglobin concentrations were similar in animals exposed to smoke from test and reference cigarettes. Plasma concentrations of nicotine and cotinine in the test groups were higher than in the reference groups. There were no differences between the smoke-exposed groups in terms of body weight or feed consumption. At necropsy, an increase in heart weight was noted in both high exposure groups. There were notable differences in histopathology, with fewer and less-pronounced changes in the test groups than in the reference groups. Many of the histopathological responses induced in the reference groups were absent in the test groups. Overall, the study demonstrated a substantial reduction in the biological activity of smoke from the test cigarette when compared with the reference.
has issue date	1989-10-31(xsd:dateTime)
bibo:doi	10.1016/0272-0590(89)90283-2
bibo:pmid	2612779
has license	els-covid
sha1sum (hex)	f2603d2893999eedb199e31c102dc357da352eb2
schema:url	https://doi.org/10.1016/0272-0590%2889%2990283-2
resource representing a document's title	Ninety-day inhalation study in rats, comparing smoke from cigarettes that heat tobacco with those that burn tobacco
has PubMed Central identifier	PMC7130492
has PubMed identifier	2612779
schema:publication	Fundamental and Applied Toxicology
resource representing a document's body	covid:f2603d2893999eedb199e31c102dc357da352eb2#body_text
is schema:about of	covid:arg/f2603d2893999eedb199e31c102dc357da352eb2 named entity 'FTC' named entity 'hemorrhage' named entity 'hematology' named entity 'cigarette' named entity 'cigarette' named entity 'Detroit' named entity 'reticulocyte count' named entity 'preignition' named entity 'uniformly distributed' named entity '2.2' named entity 'minute ventilation' named entity 'protein' named entity 'WTPM' named entity 'histopathology' named entity 'necropsy' named entity 'cigarette' named entity 'MINITAB' named entity 'lungs' named entity 'platelet' named entity 'laboratory conditions' named entity 'stomach' named entity 'inflammation' named entity 'liver' named entity 'rectum' named entity 'preignition' named entity 'exsanguinated' named entity 'WTPM' named entity 'EDTA' named entity 'goblet cells' named entity 'tobacco' named entity 'potassium' named entity 'nicotine' named entity 'particulate matter' named entity 'water pressure' named entity 'WTPM' named entity 'inhalation' named entity 'body plethysmography' named entity 'tobacco' named entity 'bronchioles' named entity 'cigarette' named entity 'hemoglobin' named entity 'goblet cells' named entity 'WTPM' named entity 'WTPM' named entity 'epithelium' named entity 'WTPM' named entity 'Sprague-Dawley' named entity 'nicotine' named entity 'cigarette' named entity 'pancreas' named entity 'urinary bladder' named entity 'alveolar sacs' named entity 'Irvine, CA' named entity 'Horiba' named entity 'tobacco' named entity 'inflammatory response' named entity 'minute ventilation' named entity 'rat' named entity 'WTPM' named entity 'periodic acid-Schiff' named entity 'histopathology' named entity 'nicotine' named entity 'carbon' named entity 'bronchi' named entity 'FTC' named entity 'goblet cells' named entity 'Dunnett's test' named entity 'kidneys' named entity 'necropsy' named entity 'exposed to smoke' named entity 'minute ventilation' named entity 'Plasma' named entity 'tobacco'

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