About: Prognosis of pathogen-proven acute respiratory distress syndrome diagnosed from a protocol that includes bronchoalveolar lavage: a retrospective observational study

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About: Prognosis of pathogen-proven acute respiratory distress syndrome diagnosed from a protocol that includes bronchoalveolar lavage: a retrospective observational study Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Prognosis of pathogen-proven acute respiratory distress syndrome diagnosed from a protocol that includes bronchoalveolar lavage: a retrospective observational study
Creator	Shime, Nobuaki Hosokawa, Koji Kida, Yoshiko Kyo, Michihito Ohshimo, Shinichiro Tanabe, Yuko
Source	PMC
abstract	BACKGROUND: To treat patients with acute respiratory distress syndrome (ARDS), it is important to diagnose specific lung diseases and identify common risk factors. Our facility focuses on using bronchoalveolar lavage (BAL) to identify precise risk factors and determine the causative pathogen of ARDS within 24 h of intensive care unit (ICU) admission. This study evaluated the prognoses of pathogen-proven ARDS patients who were diagnosed or identified with risk factors using a diagnostic protocol, which included BAL, compared with the prognoses of pathogen-unproven ARDS patients. METHODS: This retrospective observational study was conducted in the ICU at a tertiary hospital from October 2015 to January 2019. We enrolled patients with respiratory distress who were on mechanical ventilation for more than 24 h in the ICU and who were subjected to our diagnostic protocol. We compared the disease characteristics and mortality rates between pathogen-proven and pathogen-unproven ARDS patients. RESULTS: Seventy ARDS patients were included, of whom, 50 (71%) had pathogen-proven ARDS as per our protocol. Mortality rates in both the ICU and the hospital were significantly lower among pathogen-proven ARDS patients than among pathogen-unproven ARDS patients (10% vs. 50%, p = 0.0006; 18% vs. 55%, p = 0.0038, respectively). Pathogen-proven ARDS patients were independently associated with hospital survival (adjusted hazard ratio, 0.238; 95% confidence interval, 0.096–0.587; p = 0.0021). CONCLUSIONS: Our diagnostic protocol, which included early initiation of BAL, enabled diagnosing pathogen-proven ARDS in 71% of ARDS patients. These patients were significantly associated with higher hospital survival rates. The diagnostic accuracy of our diagnostic protocol, which includes BAL, remains unclear.
has issue date	2020-07-23(xsd:dateTime)
bibo:doi	10.1186/s40560-020-00469-w
has license	cc-by
sha1sum (hex)	f268b0a2f485701f03409e9ae31c60ed84dda973
schema:url	https://doi.org/10.1186/s40560-020-00469-w
resource representing a document's title	Prognosis of pathogen-proven acute respiratory distress syndrome diagnosed from a protocol that includes bronchoalveolar lavage: a retrospective observational study
has PubMed Central identifier	PMC7376525
schema:publication	J Intensive Care
resource representing a document's body	covid:f268b0a2f485701f03409e9ae31c60ed84dda973#body_text
is schema:about of	named entity 'identified' named entity 'intensive care unit (ICU)' named entity 'Our' named entity 'risk factors' named entity 'evaluated' named entity 'specific' named entity 'ACUTE RESPIRATORY DISTRESS SYNDROME' named entity 'ARDS' named entity 'IDENTIFIED' named entity 'DIAGNOSED' named entity 'ARDS' named entity 'bronchoalveolar lavage' named entity 'normal saline' named entity 'ARDS' named entity 'demographic data' named entity 'ventilator management' named entity 'pneumonia' named entity 'pancreatitis' named entity 'ARDS' named entity 'viruses' named entity 'ARDS' named entity 'neuromuscular blockage' named entity 'medical records' named entity 'ICUs' named entity 'ICU' named entity '12,000' named entity 'ARDS' named entity 'mortality rate' named entity 'ANCA' named entity 'PCR' named entity 'BALF' named entity 'pneumonia' named entity 'pathogen' named entity 'observational study' named entity 'Pathogen' named entity 'ARDS' named entity 'ARDS' named entity 'ARDS' named entity 'ECMO' named entity 'epidemic' named entity 'intubated' named entity 'septic shock' named entity 'respiratory diseases' named entity 'regression analysis' named entity 'interquartile range' named entity 'cytomegaloviruses' named entity 'ARDS' named entity 'chest X-rays' named entity 'ARDS' named entity 'acute lung injury' named entity 'etiology' named entity 'sputum culture' named entity 'pneumonia' named entity 'ARDS' named entity 'myeloperoxidase' named entity 'ARDS' named entity 'ARDS' named entity 'Loop-mediated isothermal amplification' named entity 'pneumonia' named entity 'APACHE II' named entity 'ARDS' named entity 'ANCA' named entity 'precise' named entity 'ARDS' named entity 'ARDS' named entity 'ARDS' named entity 'risk factors' named entity 'body temperature' named entity 'Berlin' named entity 'drug-induced' named entity 'tidal volume' named entity 'etiology' named entity 'fungi' named entity 'microorganisms' named entity 'antibody' named entity 'microorganisms' named entity 'interstitial pneumonia' named entity 'lung'

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