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About:
Role of computed tomography in predicting critical disease in patients with covid-19 pneumonia: A retrospective study using a semiautomatic quantitative method
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research paper
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Academic Article
research paper
schema:ScholarlyArticle
isDefinedBy
Covid-on-the-Web dataset
title
Role of computed tomography in predicting critical disease in patients with covid-19 pneumonia: A retrospective study using a semiautomatic quantitative method
Creator
Alfieri, Giulia
Cartocci, Gaia
Catalano, Carlo
Ciccarelli, Fabio
Dolciami, Miriam
Francone, Marco
Iafrate, Franco
Imperiale, Carmela
Leonardi, Andrea
Perotti, Stefano
Petrillo, Roberta
Ricci, Paolo
Scala, Annarita
Scipione, Roberto
source
Elsevier; Medline; PMC
abstract
BACKGROUND: So far, only a few studies evaluated the correlation between CT features and clinical outcome in patients with COVID-19 pneumonia. PURPOSE: To evaluate CT ability in differentiating critically ill patients requiring invasive ventilation from patients with less severe disease. METHODS: We retrospectively collected data from patients admitted to our institution for COVID-19 pneumonia between March 5th-24th. Patients were considered critically ill or non-critically ill, depending on the need for mechanical ventilation. CT images from both groups were analyzed for the assessment of qualitative features and disease extension, using a quantitative semiautomatic method. We evaluated the differences between the two groups for clinical, laboratory and CT data. Analyses were conducted on a per-protocol basis. RESULTS: 189 patients were analyzed. PaO(2)/FIO(2) ratio and oxygen saturation (SaO(2)) were decreased in critically ill patients. At CT, mixed pattern (ground glass opacities (GGO) and consolidation) and GGO alone were more frequent respectively in critically ill and in non-critically ill patients (p < 0.05). Lung volume involvement was significantly higher in critically ill patients (38.5 % vs. 5.8 %, p < 0.05). A cut-off of 23.0 % of lung involvement showed 96 % sensitivity and 96 % specificity in distinguishing critically ill patients from patients with less severe disease. The fraction of involved lung was related to lactate dehydrogenase (LDH) levels, PaO(2)/FIO(2) ratio and SaO(2) (p < 0.05). CONCLUSION: Lung disease extension, assessed using quantitative CT, has a significant relationship with clinical severity and may predict the need for invasive ventilation in patients with COVID-19.
has issue date
2020-07-29
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bibo:doi
10.1016/j.ejrad.2020.109202
bibo:pmid
32745895
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no-cc
sha1sum (hex)
f28e3c0db6370aaf31b54870905a3c91d52bc6ba
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https://doi.org/10.1016/j.ejrad.2020.109202
resource representing a document's title
Role of computed tomography in predicting critical disease in patients with covid-19 pneumonia: A retrospective study using a semiautomatic quantitative method
has PubMed Central identifier
PMC7388797
has PubMed identifier
32745895
schema:publication
Eur J Radiol
resource representing a document's body
covid:f28e3c0db6370aaf31b54870905a3c91d52bc6ba#body_text
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schema:about
of
named entity 'sensitivity'
named entity 'Results'
named entity 'features'
named entity 'involved'
named entity 'patients'
named entity 'pneumonia'
named entity 'critically ill'
named entity 'FIO'
named entity 'semiautomatic'
named entity 'ill'
named entity 'ill'
named entity 'evaluated'
named entity 'quantitative'
named entity 'ability'
named entity 'pattern'
named entity 'FIO'
named entity 'laboratory'
named entity 'patients'
named entity 'data'
named entity 'evaluate'
named entity 'ventilation'
named entity 'invasive ventilation'
named entity 'lung'
named entity 'lung'
named entity 'pneumonia'
named entity 'critically ill patients'
named entity 'CT images'
named entity 'Lung volume'
named entity 'clinical outcome'
named entity 'Lung disease'
named entity 'pneumonia'
named entity 'COVID'
named entity 'COVID'
named entity 'critically ill patients'
named entity 'quantitative method'
named entity 'retrospective study'
named entity 'Lung disease'
named entity 'chest imaging'
named entity 'lung volume'
named entity 'laboratory tests'
named entity 'CPAP'
named entity 'chronic obstructive pulmonary disease'
named entity 'lung disease'
named entity 'differential diagnosis'
named entity '1.000'
named entity 'GGO'
named entity 'severe pneumonia'
named entity 'COVID-19'
named entity 'Pneumonia'
named entity 'Germany'
named entity 'oxygen'
named entity 'pulmonary lobe'
named entity 'lung volumes'
named entity 'chest X-ray'
named entity 'SARS-CoV-2'
named entity 'critically ill patients'
named entity 'asymptomatic'
named entity 'SARS-Cov-2'
named entity 'institutional review board'
named entity 'lactate dehydrogenase'
named entity 'infection'
named entity 'throat swab'
named entity 'evolution'
named entity 'cut-off'
named entity 'COVID-19'
named entity 'pleural diseases'
named entity '1, 2'
named entity 'significant difference'
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