About: Differential expression of serum/plasma proteins in various infectious diseases: Specific or nonspecific signatures

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Differential expression of serum/plasma proteins in various infectious diseases: Specific or nonspecific signatures
Creator	Patel, Sandip Ray, Sandipan Srivastava, Sanjeeva Damahe, Jagruti Kumar, Vipin
source	Medline; PMC
abstract	Apart from direct detection of the infecting organisms or biomarker of the pathogen itself, surrogate host markers are also useful for sensitive and early diagnosis of pathogenic infections. Early detection of pathogenic infections, discrimination among closely related diseases with overlapping clinical manifestations, and monitoring of disease progression can be achieved by analyzing blood biomarkers. Therefore, over the last decade large numbers of proteomics studies have been conducted to identify differentially expressed human serum/plasma proteins in different infectious diseases with the intent of discovering novel potential diagnostic/prognostic biomarkers. However, in‐depth review of the literature indicates that many reported biomarkers are altered in the same way in multiple infectious diseases, regardless of the type of infection. This might be a consequence of generic acute phase reactions, while the uniquely modulated candidates in different pathogenic infections could be indicators of some specific responses. In this review article, we will provide a comprehensive analysis of differentially expressed serum/plasma proteins in various infectious diseases and categorize the protein markers associated with generic or specific responses. The challenges associated with the discovery, validation, and translational phases of serum/plasma biomarker establishment are also discussed.
has issue date	2013-12-27(xsd:dateTime)
bibo:doi	10.1002/prca.201300074
bibo:pmid	24293340
has license	no-cc
sha1sum (hex)	f2ae2405ecb14e7d58087a201c46881a8eef6e92
schema:url	https://doi.org/10.1002/prca.201300074
resource representing a document's title	Differential expression of serum/plasma proteins in various infectious diseases: Specific or nonspecific signatures
has PubMed Central identifier	PMC7168033
has PubMed identifier	24293340
schema:publication	Proteomics Clin Appl
resource representing a document's body	covid:f2ae2405ecb14e7d58087a201c46881a8eef6e92#body_text
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