About: Quantitative trace analysis of a broad range of antiviral drugs in poultry muscle using column-switch liquid chromatography coupled to tandem mass spectrometry

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About: Quantitative trace analysis of a broad range of antiviral drugs in poultry muscle using column-switch liquid chromatography coupled to tandem mass spectrometry Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Quantitative trace analysis of a broad range of antiviral drugs in poultry muscle using column-switch liquid chromatography coupled to tandem mass spectrometry
Creator	Weigel, Stefan Berendsen, Bjorn Essers, Martien Stolker, Alida Wegh, Robin
Source	Medline; PMC
abstract	A liquid chromatography–tandem mass spectrometry method for the analysis of seven antiviral drugs, zanamivir, ribavirin, oseltamivir, oseltamivir carboxylate, amantadine, rimantadine and arbidol, in poultry muscle is reported. The antiviral drugs were extracted from the homogenized poultry muscle sample using methanol. The extract was purified using tandem solid-phase extraction combining a cation exchange cartridge and a phenylboronic acid cartridge. To prevent excessive matrix effects, the analytes were separated from the matrix constituents using a column-switch liquid chromatography system combining a reversed-phase and a Hypercarb analytical column. Detection was carried out using tandem mass spectrometry. The method was fully validated according to 2002/657/EC [1] and proved to be adequate for quantification and confirmation of zanamivir and ribavirin at 10 μg kg(−1), oseltamivir, oseltamivir carboxylate, amantadine and rimantadine at levels below 1.0 μg kg(−1) and for qualitative confirmatory analysis of arbidol at levels below 1 μg kg(−1). ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00216-011-5581-3) contains supplementary material, which is available to authorized users.
has issue date	2011-12-16(xsd:dateTime)
bibo:doi	10.1007/s00216-011-5581-3
bibo:pmid	22173207
has license	no-cc
sha1sum (hex)	f2ea312712d4e9fbe371d2ccb5cfdca0c6348c53
schema:url	https://doi.org/10.1007/s00216-011-5581-3
resource representing a document's title	Quantitative trace analysis of a broad range of antiviral drugs in poultry muscle using column-switch liquid chromatography coupled to tandem mass spectrometry
has PubMed Central identifier	PMC3262966
has PubMed identifier	22173207
schema:publication	Anal Bioanal Chem
resource representing a document's body	covid:f2ea312712d4e9fbe371d2ccb5cfdca0c6348c53#body_text
is schema:about of	named entity 'prevent' named entity 'cartridge' named entity 'The' named entity 'mass spectrometry' named entity 'ribavirin' named entity 'zanamivir' named entity 'antiviral drugs' named entity 'COUPLED' named entity 'TRACE' named entity 'COLUMN' named entity 'POULTRY' named entity 'AT 10' named entity 'OSELTAMIVIR CARBOXYLATE' named entity 'ARBIDOL' named entity 'RIBAVIRIN' named entity 'QUANTIFICATION' named entity 'TANDEM MASS SPECTROMETRY' named entity 'CONSTITUENTS' named entity 'POULTRY' named entity 'TANDEM' named entity 'AMANTADINE' named entity 'SEPARATED FROM' named entity 'CATION' named entity 'CONFIRMATORY' named entity 'ANALYSIS' named entity 'SWITCH' named entity 'MUSCLE' named entity 'BROAD' named entity 'ANTIVIRAL DRUGS' named entity 'EFFECTS' named entity 'METHOD' named entity 'COLUMN' named entity 'CARTRIDGE' named entity 'TO PREVENT' named entity 'USING' named entity 'QUANTITATIVE' named entity 'LIQUID CHROMATOGRAPHY ' named entity 'TANDEM MASS SPECTROMETRY' named entity 'ANTIVIRAL DRUGS' named entity 'CARRIED' named entity 'EXTRACTED' named entity 'REVERSED' named entity 'OSELTAMIVIR' named entity '5B1' named entity 'EXCHANGE' named entity 'ANALYTICAL COLUMN' named entity 'FULLY' named entity 'PURIFIED' named entity 'METHANOL' named entity 'ANALYTES' named entity 'RANGE' named entity 'CONFIRMATION OF' named entity 'SEVEN' named entity 'LEVELS' named entity 'DETECTION' named entity 'ANALYSIS' named entity 'VALIDATED' named entity 'QUALITATIVE' named entity 'PHENYLBORONIC ACID' named entity 'REPORTED' named entity 'LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY' named entity 'PHASE' named entity 'EXCESSIVE' named entity 'SOLID-PHASE EXTRACTION' named entity '921' named entity 'USING' named entity 'RIMANTADINE' named entity 'EXTRACT' named entity 'LIQUID CHROMATOGRAPHY SYSTEM' named entity 'BCG' named entity 'MATRIX' named entity 'COMBINING' named entity 'SAMPLE' named entity 'ADEQUATE' named entity 'MUSCLE' named entity 'ACCORDING' named entity 'SWITCH'

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