About: Respiratory Pathogens in Children with and without Respiratory Symptoms

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Respiratory Pathogens in Children with and without Respiratory Symptoms
Creator	Wilbrink, Berry Wolfs, Tom Uiterwaal, S Van Der Ent, Cornelis Van Der Zalm, Marieke Van Ewijk, Bart
source	Elsevier; Medline; PMC
abstract	Objectives To investigate the occurrence of respiratory pathogens in samples from children with and without respiratory symptoms and to identify whether age and/ or coinfections modify the impact of respiratory pathogens on symptoms. Study design In a prospective longitudinal study, 18 children were sampled biweekly for respiratory pathogens, irrespective of respiratory symptoms. Polymerase chain reaction was performed for 13 respiratory pathogens. Episodes were defined “asymptomatic” if no symptoms of any respiratory tract illness were present between 1 week before and 1 week after sampling. Results A total of 230 samples were collected. In 56% of the symptomatic episodes, a pathogen was detected, compared with 40% of the asymptomatic episodes (P = .03). Rhinovirus and coronaviruses were most prevalent in both symptomatic and asymptomatic episodes. In the youngest children, 9% of the pathogen-positive episodes were asymptomatic, compared with 36% in the oldest children (P = .01). Multiple pathogens were found in 17% of the symptomatic episodes and in 3% of the asymptomatic episodes (P = .02). Conclusions Respiratory pathogens are frequently detected in samples from children with no respiratory symptoms. Symptomatic cases occurred more often in younger children and with detections of more than 1 respiratory pathogen.
has issue date	2009-03-31(xsd:dateTime)
bibo:doi	10.1016/j.jpeds.2008.08.036
bibo:pmid	18823911
has license	els-covid
sha1sum (hex)	f357f47521ed41c7f2abb2c41fb3fab57cd37a51
schema:url	https://doi.org/10.1016/j.jpeds.2008.08.036
resource representing a document's title	Respiratory Pathogens in Children with and without Respiratory Symptoms
has PubMed Central identifier	PMC7094528
has PubMed identifier	18823911
schema:publication	The Journal of Pediatrics
resource representing a document's body	covid:f357f47521ed41c7f2abb2c41fb3fab57cd37a51#body_text
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