About: Quantification of Torque Teno Virus and Epstein-Barr Virus Is of Limited Value for Predicting the Net State of Immunosuppression After Lung Transplantation

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Quantification of Torque Teno Virus and Epstein-Barr Virus Is of Limited Value for Predicting the Net State of Immunosuppression After Lung Transplantation Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Quantification of Torque Teno Virus and Epstein-Barr Virus Is of Limited Value for Predicting the Net State of Immunosuppression After Lung Transplantation
Creator	Lundin, Anna Lindh, Magnus Nilsson, Staffan Andersson, Lars-Magnus Westin, Johan Magnusson, Jesper Nordén, Rickard Tang, Ka-Wei Riise, Gerdt
source	Medline; PMC
abstract	BACKGROUND: Major hurdles for survival after lung transplantation are rejections and infectious complications. Adequate methods for monitoring immune suppression status are lacking. Here, we evaluated quantification of torque teno virus (TTV) and Epstein-Barr virus (EBV) as biomarkers for defining the net state of immunosuppression in lung-transplanted patients. METHODS: This prospective single-center study included 98 patients followed for 2 years after transplantation. Bacterial infections, fungal infections, viral respiratory infections (VRTI), cytomegalovirus (CMV) viremia, and acute rejections, as well as TTV and EBV levels, were monitored. RESULTS: The levels of torque teno virus DNA increased rapidly after transplantation, likely due to immunosuppressive treatment. A modest increase in levels of Epstein-Barr virus DNA was also observed after transplantation. There were no associations between either TTV or EBV and infectious events or acute rejection, respectively, during follow-up. When Tacrolimus was the main immunosuppressive treatment, TTV DNA levels were significantly elevated 6–24 months after transplantation as compared with Cyclosporine treatment. CONCLUSIONS: Although replication of TTV, but not EBV, appears to reflect the functionality of the immune system, depending on the type of immunosuppressive treatment, quantification of TTV or EBV as biomarkers has limited potential for defining the net state of immune suppression.
has issue date	2018-03-06(xsd:dateTime)
bibo:doi	10.1093/ofid/ofy050
bibo:pmid	29644247
has license	cc-by-nc-nd
sha1sum (hex)	f3725ca2fdaeaaf188c63878e4c6263408e52aa2
schema:url	https://doi.org/10.1093/ofid/ofy050
resource representing a document's title	Quantification of Torque Teno Virus and Epstein-Barr Virus Is of Limited Value for Predicting the Net State of Immunosuppression After Lung Transplantation
has PubMed Central identifier	PMC5888719
has PubMed identifier	29644247
schema:publication	Open Forum Infect Dis
resource representing a document's body	covid:f3725ca2fdaeaaf188c63878e4c6263408e52aa2#body_text
is schema:about of	named entity 'IMMUNOSUPPRESSION' named entity 'INFECTIOUS COMPLICATIONS' named entity 'LACKING' named entity 'PATIENTS' named entity 'EVALUATED' named entity 'LUNG TRANSPLANTATION' named entity 'NET' named entity 'DEFINING' named entity 'lung transplantation' named entity 'biomarkers' named entity 'complications' named entity 'LUNG TRANSPLANTATION' named entity 'TORQUE TENO VIRUS' named entity 'INFECTIOUS DISEASES' named entity 'IMMUNOSUPPRESSION' named entity 'VALUE' named entity 'ADEQUATE' named entity 'TORQUE TENO VIRUS' named entity 'TRANSPLANTED' named entity 'STATUS' named entity 'MAJOR' named entity 'STATE' named entity 'NET' named entity 'STATE' named entity 'FORUM' named entity 'OPEN' named entity 'HERE' named entity 'PREDICTING' named entity 'QUANTIFICATION' named entity 'IMMUNE SUPPRESSION' named entity 'BIOMARKERS' named entity 'EPSTEIN-BARR VIRUS' named entity 'QUANTIFICATION' named entity 'LIMITED' named entity 'EPSTEIN-BARR VIRUS' named entity 'LUNG' named entity 'METHODS' named entity 'SURVIVAL' named entity 'MONITORING' covid:arg/f3725ca2fdaeaaf188c63878e4c6263408e52aa2 named entity 'EBV' named entity 'virus' named entity 'survival' named entity 'Limited' named entity 'torque teno virus' named entity 'Immunosuppression' named entity 'serum level' named entity 'double lung transplant' named entity 'intravenous therapy' named entity 'ablation' named entity 'blood samples' named entity 'bronchoscopy' named entity 'biopsy' named entity 'Poisson statistics' named entity 'acute rejection' named entity 'antifungal' named entity 'immunosuppressive drugs' named entity 'TTV' named entity 'prospective study' named entity 'EBV' named entity 'solid tumors' named entity 'biomarkers' named entity 'nucleic acid' named entity 'LTx' named entity 'TTV' named entity 'seropositive' named entity 'EBV' named entity 'LTx' named entity 'acute rejection' named entity 'EBV' named entity 'TTV' named entity 'Tacrolimus' named entity 'Tacrolimus'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software