About: Level of IL-6 predicts respiratory failure in hospitalized symptomatic COVID-19 patients

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About: Level of IL-6 predicts respiratory failure in hospitalized symptomatic COVID-19 patients Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Level of IL-6 predicts respiratory failure in hospitalized symptomatic COVID-19 patients
Creator	Arnreich, Chiara Hellmuth, Johannes Herold, Tobias Jurinovic Phd, Vindi Klein, Matthias Von Bergwelt-Baildon, Michael Weinberger, Tobias
Source	MedRxiv
abstract	The pandemic Coronavirus-disease 19 (COVID-19) is characterized by a heterogeneous clinical course. While most patients experience only mild symptoms, a relevant proportion develop severe disease progression with increasing hypoxia up to acute respiratory distress syndrome. The substantial number of patients with severe disease have strained intensive care capacities to an unprecedented level. Owing to the highly variable course and lack of reliable predictors for deterioration, we aimed to identify variables that allow the prediction of patients with a high risk of respiratory failure and need of mechanical ventilation Patients with PCR proven symptomatic COVID-19 infection hospitalized at our institution from 29th February to 27th March 2020 (n=40) were analyzed for baseline clinical and laboratory findings. Patients requiring mechanical ventilation 13/40 (32.5%) did not differ in age, comorbidities, radiological findings, respiratory rate or qSofa score. However, elevated interleukin-6 (IL-6) was strongly associated with the need for mechanical ventilation (p=1.2.10-5). In addition, the maximal IL-6 level (cutoff 80 pg/ml) for each patient during disease predicted respiratory failure with high accuracy (p=1.7.10-8, AUC=0.98). The risk of respiratory failure for patients with IL-6 levels of ≥ 80 pg/ml was 22 times higher compared to patients with lower IL-6 levels. In the current situation with overwhelmed intensive care units and overcrowded emergency rooms, correct triage of patients in need of intensive care is crucial. Our study shows that IL-6 is an effective marker that might be able to predict upcoming respiratory failure with high accuracy and help physicians correctly allocate patients at an early stage.
has issue date	2020-04-04(xsd:dateTime)
bibo:doi	10.1101/2020.04.01.20047381
has license	medrxiv
sha1sum (hex)	f37732efdb488697a50d86e8a37d9cac91a3474e
schema:url	https://doi.org/10.1101/2020.04.01.20047381
resource representing a document's title	Level of IL-6 predicts respiratory failure in hospitalized symptomatic COVID-19 patients
resource representing a document's body	covid:f37732efdb488697a50d86e8a37d9cac91a3474e#body_text
is schema:about of	named entity 'IL-6' named entity 'SYMPTOMATIC' named entity 'respiratory rate' named entity 'PCR' named entity 'variable' named entity 'IL-6' named entity 'COVID-19' named entity 'LACK' named entity 'RELEVANT' named entity 'DISEASE PROGRESSION' named entity 'INCREASING' named entity 'PATIENTS' named entity 'PREDICTION' named entity 'PROPORTION' named entity 'FEBRUARY' named entity 'MECHANICAL VENTILATION' named entity 'COMORBIDITIES' named entity 'BASELINE' named entity 'HETEROGENEOUS' named entity 'STRAINED' named entity 'MILD SYMPTOMS' named entity 'CHARACTERIZED' covid:arg/f37732efdb488697a50d86e8a37d9cac91a3474e named entity 'VARIABLE' named entity 'INSTITUTION' named entity 'AGE' named entity 'MARCH' named entity 'VARIABLES' named entity 'ACUTE RESPIRATORY DISTRESS SYNDROME' named entity 'UP TO' named entity 'FINDINGS' named entity 'SEVERE DISEASE' named entity 'LEVEL' named entity 'NEED' named entity 'PROVEN' named entity 'INTERLEUKIN-6 ' named entity 'LEVEL' named entity 'HOSPITALIZED' named entity 'RESPIRATORY FAILURE' named entity 'COVID-19' named entity 'DETERIORATION' named entity 'COURSE' named entity 'DISEASE' named entity 'SCORE' named entity 'PCR' named entity 'HYPOXIA' named entity 'HAVE' named entity 'LABORATORY' named entity 'CLINICAL COURSE' named entity 'RELIABLE' named entity 'HIGHLY' named entity 'NEED FOR' named entity 'EXPERIENCE' named entity 'OUR' named entity 'PANDEMIC' named entity '28P' named entity 'INTENSIVE CARE' named entity 'TO IDENTIFY' named entity 'ASSOCIATED WITH' named entity 'HIGH RISK OF' named entity 'RESPIRATORY RATE' named entity 'NUMBER OF PATIENTS' named entity 'SYMPTOMATIC' named entity 'ALLOW' named entity 'DID' named entity 'CLINICAL' named entity 'RESPIRATORY FAILURE' named entity 'ELEVATED' named entity 'ANALYZED' named entity 'CORONAVIRUS' named entity 'PATIENTS' named entity 'HOSPITALIZED' named entity 'level' named entity 'acute respiratory distress syndrome' named entity 'severe' named entity 'February' named entity 'Patients' named entity 'March' named entity 'symptoms'

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