About: Induction of immature dendritic cell apoptosis by foot and mouth disease virus is an integrin receptor mediated event before viral infection

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About: Induction of immature dendritic cell apoptosis by foot and mouth disease virus is an integrin receptor mediated event before viral infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Induction of immature dendritic cell apoptosis by foot and mouth disease virus is an integrin receptor mediated event before viral infection
Creator	Wang, Bin Yu, Yang Jin, Huali Kang, Youmin Xiao, Chong Zhao, Gan Du, Xiaogang
Source	Medline; PMC
abstract	Foot and mouth disease virus (FMDV) has been demonstrated to infect dendritic cells (DC) and reduced its ability to stimulate host immune responses. This study aimed to determine whether non‐replicating FMDV could induce apoptosis of the host immune cells. In this study, we have demonstrated that bone morrow derived dendritic cells (BMDCs) were induced to undergo apoptosis in a dose‐dependent manner, which was determined by the annexin‐V staining, DNA fragmentation, and TUNEL staining methods, after they were treated with the chemically inactivated FMDV in vitro. The initiation of apoptosis was apparently via an interaction of the integrin receptor on BMDCs and the RGD motif within the VP1 capsid protein of FMDV. The initiation activated a cascade of apoptotic pathway including reduced expression of Bcl‐2, activation of caspases, and release of cytochrome c from mitochondria. Pretreatment with BMDCs with LPS prevented the inactivated FMDV induced apoptosis, suggesting immature BMDCs are susceptible to such apoptosis. Taken together, the data demonstrate that the inactivated FMDV induces the apoptosis in BMDCs via the integrin receptor and subsequently triggers the apoptosis signal, suggesting that such induction of apoptosis is likely to impair immune responses against FMDV infection. J. Cell. Biochem. 102: 980–991, 2007. © 2007 Wiley‐Liss, Inc.
has issue date	2007-04-11(xsd:dateTime)
bibo:doi	10.1002/jcb.21332
bibo:pmid	17427949
has license	no-cc
sha1sum (hex)	f38a347e495fc6f4ba857b22090810bef93d1417
schema:url	https://doi.org/10.1002/jcb.21332
resource representing a document's title	Induction of immature dendritic cell apoptosis by foot and mouth disease virus is an integrin receptor mediated event before viral infection
has PubMed Central identifier	PMC7166979
has PubMed identifier	17427949
schema:publication	J Cell Biochem
resource representing a document's body	covid:f38a347e495fc6f4ba857b22090810bef93d1417#body_text
is schema:about of	named entity 'mitochondria' named entity 'host' named entity 'apoptosis' named entity 'chemically' named entity 'Apoptosis' named entity 'bone' named entity 'dendritic cells (DC)' named entity 'cascade' named entity 'TUNEL' named entity 'triggers' named entity 'staining' named entity 'apoptosis' named entity 'LPS' named entity 'apoptosis' named entity 'FMDV' named entity 'capsid protein' named entity 'integrin receptor' named entity 'integrin receptor' named entity 'FMDV' named entity 'dendritic cells' named entity 'FMDV' named entity 'caspases' named entity 'immune cells' named entity 'Integrin Receptor' named entity 'Immature' named entity 'aprotinin' named entity 'broadspectrum' named entity 'antibodies' named entity 'FMDV' named entity 'capsid protein' named entity 'lysed' named entity 'caspase-9' named entity 'bovine' named entity 'LPS' named entity 'FMDV' named entity 'HBsAg' named entity 'Bcl-2 family' named entity 'FMDV' named entity 'FMDV' named entity 'intracellular' named entity 'FACS' named entity 'intracellular' named entity 'mitochondria' named entity 'GM-CSF' named entity 'China' named entity 'immune surveillance' named entity 'apoptosis' named entity 'FMDV' named entity 'mitochondria' named entity 'downregulation' named entity 'Annexin' named entity 'BD Biosciences' named entity 'acute infection' named entity 'paraformaldehyde' named entity 'HBsAg' named entity 'Acute infection' named entity 'mammalian cells' named entity 'cell surface proteins' named entity 'supernatant' named entity 'apoptosis' named entity 'cytochrome' named entity 'FMDV' named entity 'caspase-1' named entity 'apoptosis' named entity 'FMDV' named entity 'Fc receptors' named entity 'lipopolysaccharide' named entity 'apoptosis' named entity 'FMDV' named entity 'infection' named entity 'death receptor' named entity 'infection' named entity 'hemocytometer' named entity 'Bcl-XL' named entity 'acute phase'

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