About: A comparative study of the etiology of adult upper and lower respiratory tract infections in the community

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About: A comparative study of the etiology of adult upper and lower respiratory tract infections in the community Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A comparative study of the etiology of adult upper and lower respiratory tract infections in the community
Creator	Ben-Yaakov, Miriam Boldur, Ida Dvoskin, Bella Korsonsky, Igor Lazarovich, Zilia Leinonen, Maija Lieberman, David Lieberman, Devora Ohana, Bella Friedman, Maureen
Source	Elsevier; Medline; PMC
abstract	Abstract Lower respiratory tract infection and upper respiratory tract infection (URTI) are very common, but the etiology is not diagnosed in routine practice. The objective of this study was to determine and compare the frequency distribution of the various infectious etiologies for these diseases. One hundred seventy five adults in the community with febrile LRTI and 75 with febrile URTI were included in a purely serologically based prospective study. Paired sera were obtained for each of the patients and were tested by EIA or immunofluorescence methods to identify 14 different pathogens. Only a significant change in antibody titers between the paired sera was considered diagnostic. At least one infectious etiology was identified in 167 patients (67%). In the LRTI group, infection with at least one of 7 respiratory viruses was found in 88 patients (50%). One of the atypical pathogens was found in 40 patients (23%), of these Legionella spp. in 19 (11%) and Mycoplasma pneumoniae in 18 (10%). A bacterial etiology was found in 19 patients (11%), of these Streptococcus pneumoniae in 8 (5%) and β-hemolytic streptococci group A in 5 (3%). The frequency distribution of etiologies in the URTI group was not significantly different from the LRTI group, except for M. pneumoniae that was identified in only one patient with URTI (p = 0.015). More than one etiologic agent was found in 42 (17%) of the patients. LRTI is caused by a broad spectrum of etiologies, with respiratory viruses predominating and a moderate, but significant, prevalence of atypical pathogens. The frequency distribution of etiologies for URTI is similar to LRTI. In a significant proportion of patients with URTI and LRTI there is serologic evidence of infection with more than one pathogen. The justification and benefit of distinguishing between URTI and LRTI in routine clinical work is doubtful. When a decision is reached to treat RTI patients with an antibiotic, it is logical to use a macrolide or tetracycline.
has issue date	2002-01-31(xsd:dateTime)
bibo:doi	10.1016/s0732-8893(01)00324-8
bibo:pmid	11821167
has license	els-covid
sha1sum (hex)	f3f82089b3547cc954ffe4d32ea1094364e136fd
schema:url	https://doi.org/10.1016/s0732-8893%2801%2900324-8
resource representing a document's title	A comparative study of the etiology of adult upper and lower respiratory tract infections in the community
has PubMed Central identifier	PMC7134668
has PubMed identifier	11821167
schema:publication	Diagnostic Microbiology and Infectious Disease
resource representing a document's body	covid:f3f82089b3547cc954ffe4d32ea1094364e136fd#body_text
is schema:about of	named entity 'etiologic agent' named entity 'patients' named entity 'reached' named entity 'study' named entity 'upper respiratory tract infection' named entity 'pathogens' named entity 'treat' named entity 'etiology' named entity 'respiratory tract infections' named entity 'ANTIBIOTIC' named entity 'PNEUMONIAE' named entity 'SEVENTY FIVE' named entity 'DETERMINE' named entity 'ONE OF' named entity 'EVIDENCE OF' named entity 'ATYPICAL' named entity 'OBJECTIVE' named entity 'CONSIDERED' named entity '283' named entity 'DISEASES' named entity 'PATIENTS' named entity 'RESPIRATORY VIRUSES' named entity 'MACROLIDE' named entity 'DIAGNOSED' named entity 'DOUBTFUL' named entity 'SIMILAR' named entity 'COMMUNITY' named entity 'SIGNIFICANT' named entity 'SERA' named entity 'LEGIONELLA' named entity 'COMMON' named entity '0.015' named entity 'ONE HUNDRED' named entity 'UPPER RESPIRATORY TRACT INFECTION' named entity 'GROUP' named entity 'TETRACYCLINE' named entity 'USE' named entity 'INCLUDED' named entity 'JUSTIFICATION' named entity 'TESTED' named entity 'PREVALENCE' named entity 'MORE THAN ONE' named entity 'OBTAINED' named entity 'THESE' named entity 'DECISION' named entity 'PREDOMINATING' named entity 'FREQUENCY DISTRIBUTION' named entity 'UPPER' named entity 'STUDY' named entity 'URTI' named entity 'ETIOLOGY' named entity 'STREPTOCOCCI' named entity 'BENEFIT' named entity 'TO IDENTIFY' named entity 'EIA' named entity 'IDENTIFIED' named entity 'COMPARE' named entity 'BASED' named entity 'ADULTS' named entity 'BACTERIAL' named entity 'PROPORTION' named entity 'TREAT' named entity '28P' named entity 'INFECTIOUS' named entity 'INFECTION' named entity 'PATIENT' named entity 'DIFFERENT' named entity 'LOWER RESPIRATORY TRACT INFECTION' named entity 'CHANGE IN' named entity 'HEMOLYTIC' named entity 'COMMUNITY' named entity 'ADULT'

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