About: Genetic characterization of type 2a canine parvoviruses from Taiwan reveals the emergence of an Ile324 mutation in VP2

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About: Genetic characterization of type 2a canine parvoviruses from Taiwan reveals the emergence of an Ile324 mutation in VP2 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Genetic characterization of type 2a canine parvoviruses from Taiwan reveals the emergence of an Ile324 mutation in VP2
Creator	Chueh, Ling-Ling Chiou, Ming-Tang Lin, Chao-Nan Hsu, Han-Siang Chien, Chi-Hsien Hung, Meng-Yu
source	PMC
abstract	BACKGROUND: Canine parvovirus 2 (CPV 2) is a major infectious cause of mortality in puppies. The characteristic symptom of CPV 2 disease is intestinal hemorrhage with severe bloody diarrhea. Soon after CPV was first recognized in the late 1970s, the original virus, CPV 2, was replaced in the canine population by strains carrying minor antigenic variants (termed 2a, 2b, and 2c) of the VP2 gene that could be distinguished using monoclonal antibodies and molecular analyses. Here, we provide an updated molecular characterization of the CPV 2 circulating in Taiwan. METHODS: In this study, 28 isolates of CPV 2 from 144 dogs with suspected CPV infection were obtained from northern, central, and southern Taiwan from 2008 to 2012 and screened by PCR. The 28 isolates were sequenced, and a phylogenetic analysis of the VP2 gene was performed. RESULTS: Of the 28 Taiwanese CPV 2 isolates, 15 were identified as new CPV 2a, and 13 were identified as new CPV 2b. Compared to the reference CPV 2a, all 15 of the CPV 2a sequences collected in this study contain an Ile324 mutation caused by a TAT to ATT mutation at nucleotides 970–972 of the VP2 gene. CONCLUSION: Our VP2 sequence data revealed that both types are currently prevalent CPV 2 field strains circulating in Taiwan, and a unique Ile324 VP2 mutation was found in our Taiwanese CPV 2a isolates and recent Asian isolates. CPV 2c was not observed in this study.
has issue date	2014-02-25(xsd:dateTime)
bibo:doi	10.1186/1743-422x-11-39
bibo:pmid	24568207
has license	cc-by
sha1sum (hex)	f4237ea9635b4330639d7f678c719a05f7c9d8a3
schema:url	https://doi.org/10.1186/1743-422x-11-39
resource representing a document's title	Genetic characterization of type 2a canine parvoviruses from Taiwan reveals the emergence of an Ile324 mutation in VP2
has PubMed Central identifier	PMC3944821
has PubMed identifier	24568207
schema:publication	Virol J
resource representing a document's body	covid:f4237ea9635b4330639d7f678c719a05f7c9d8a3#body_text
is schema:about of	named entity '2008' named entity 'CPV' named entity '2012' named entity 'monoclonal antibodies' named entity 'VP2' named entity 'TYPE' covid:arg/f4237ea9635b4330639d7f678c719a05f7c9d8a3 named entity 'TAIWAN' named entity 'MINOR' named entity '144' named entity 'CHARACTERISTIC' named entity 'PROVIDE' named entity 'CARRYING' named entity 'CENTRAL' named entity 'PCR' named entity 'REVEALS' named entity 'BLOODY DIARRHEA' named entity 'PUPPIES' named entity 'MOLECULAR' named entity 'A MAJOR' named entity 'MUTATION' named entity 'EMERGENCE' named entity 'GENETIC CHARACTERIZATION' named entity 'PARVOVIRUSES' named entity 'INFECTIOUS CAUSE' named entity 'STUDY' named entity 'DISEASE' named entity 'VIRUS' named entity 'HERE' named entity 'VARIANTS' named entity 'BACKGROUND' named entity 'UPDATED' named entity 'INTESTINAL HEMORRHAGE' named entity 'MONOCLONAL ANTIBODIES' named entity 'OBTAINED' named entity 'NORTHERN' named entity 'SOUTHERN' named entity 'PHYLOGENETIC ANALYSIS' named entity 'SUSPECTED' named entity 'PERFORMED' named entity 'CIRCULATING' named entity 'METHODS' named entity 'LATE' named entity 'CANINE' named entity 'DOGS' named entity 'CHARACTERIZATION' named entity 'ISOLATES' named entity 'TAIWAN' named entity 'VP2' named entity 'MORTALITY' named entity 'GENE' named entity 'IS A' named entity 'INFECTION' named entity 'SOON AFTER' named entity 'COULD BE' named entity 'POPULATION' named entity 'CANINE PARVOVIRUS' named entity 'CPV' named entity 'CANINE' named entity 'SEVERE' named entity 'ORIGINAL' named entity 'REPLACED' named entity 'SYMPTOM' named entity 'USING' named entity 'STRAINS' named entity 'PCR' named entity 'population' named entity 'CPV' named entity 'Taiwan' named entity 'Taiwan' named entity 'late' named entity 'Canine parvovirus' named entity 'infection' named entity 'Canine parvovirus' named entity 'antigenic' named entity 'phylogenetic analysis'

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