About: Analysis on herbal medicines utilized for treatment of COVID-19

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Analysis on herbal medicines utilized for treatment of COVID-19
Creator	Zhang, Hui Chen, Shilin Zhou, Yumei Wang, Cheng Fitzgerald, Martin Hu, Weifeng Jiang, Jingwen Luo, Lu
Source	Elsevier; Medline; PMC
abstract	As coronavirus disease 2019 (COVID-19) pandemic poses a substantial global public health threat, traditional Chinese medicine (TCM) was used in 91.50% of the COVID-19 cases in China, showing encouraging results in improving symptom management and reducing the deterioration, mortality, and recurrence rates. A total of 166 modified herbal formulae consisting of 179 single herbal medicines were collected for treating COVID-19 in China. Glycyrrhizae Radix et Rhizome, Scutellariae Radix, and Armeniacae Semen Amarum are the most frequently utilized in clinics, most of which are antipyretic (47, 26.26%), expectorant and cough-suppressing (22, 12.29%), and dampness-resolving (21, 11.73%) from traditional descriptions. A total of 1212 chemical components containing β-sitosterol, stigmasterol, and quercetin were primarily selected. Additionally, using complex system entropy and unsupervised hierarchical clustering, 8 core herbal combinations and 10 new formulae emerged as potentially useful candidates for COVID-19. Finally, following scaffold analysis, self-organizing mapping (SOM) and cluster analysis, 12 clusters of molecules yielded 8 pharmacophore families of structures that were further screened as pharmacological targets in human metabolic pathways for inhibiting coronavirus. This article aims to make more easily accessible and share historical herbal knowledge used in contemporary treatments in a modern manner to assist researchers contain the global spread of COVID-19.
has issue date	2020-05-27(xsd:dateTime)
bibo:doi	10.1016/j.apsb.2020.05.007
bibo:pmid	32834949
has license	no-cc
sha1sum (hex)	f436eb0cdcc653135a5dc106752cf01f7e6b01b4
schema:url	https://doi.org/10.1016/j.apsb.2020.05.007
resource representing a document's title	Analysis on herbal medicines utilized for treatment of COVID-19
has PubMed Central identifier	PMC7251357
has PubMed identifier	32834949
schema:publication	Acta Pharm Sin B
resource representing a document's body	covid:f436eb0cdcc653135a5dc106752cf01f7e6b01b4#body_text
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