About: Histopathology of Middle East respiratory syndrome coronovirus (MERS‐CoV) infection – clinicopathological and ultrastructural study

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About: Histopathology of Middle East respiratory syndrome coronovirus (MERS‐CoV) infection – clinicopathological and ultrastructural study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Histopathology of Middle East respiratory syndrome coronovirus (MERS‐CoV) infection – clinicopathological and ultrastructural study
Creator	Al-Jahdali, Hamdan Baharoon, Salim Balkhy, Hanan Hajeer, Ali Arabi, Yaseen Alsolamy, Sami Aljohani, Sameera Ajlan, Al Al Ajlan, Abdulaziz Al Balwi, Mohammed Al Moaiqel, Mohammed Al Oudah, Nourah Al-Jahdali, Balkhy Alsaad, Khaled Arabi, Baharoon Balwi, Al Gmati, Giamal Moaiqel, Al Oudah, Al
Source	Medline; PMC
abstract	AIMS: The pathogenesis, viral localization and histopathological features of Middle East respiratory syndrome – coronavirus (MERS‐CoV) in humans are not described sufficiently. The aims of this study were to explore and define the spectrum of histological and ultrastructural pathological changes affecting various organs in a patient with MERS‐CoV infection and represent a base of MERS‐CoV histopathology. METHODS AND RESULTS: We analysed the post‐mortem histopathological findings and investigated localisation of viral particles in the pulmonary and extrapulmonary tissue by transmission electron microscopic examination in a 33‐year‐old male patient of T cell lymphoma, who acquired MERS‐CoV infection. Tissue needle biopsies were obtained from brain, heart, lung, liver, kidney and skeletal muscle. All samples were collected within 45 min from death to reduce tissue decomposition and artefact. Histopathological examination showed necrotising pneumonia, pulmonary diffuse alveolar damage, acute kidney injury, portal and lobular hepatitis and myositis with muscle atrophic changes. The brain and heart were histologically unremarkable. Ultrastructurally, viral particles were localised in the pneumocytes, pulmonary macrophages, renal proximal tubular epithelial cells and macrophages infiltrating the skeletal muscles. CONCLUSION: The results highlight the pulmonary and extrapulmonary pathological changes of MERS‐CoV infection and provide the first evidence of the viral presence in human renal tissue, which suggests tissue trophism for MERS‐CoV in kidney.
has issue date	2017-11-21(xsd:dateTime)
bibo:doi	10.1111/his.13379
bibo:pmid	28858401
has license	no-cc
sha1sum (hex)	f44fdbe9d42a0d80368becfb7cf4d8b41050e654
schema:url	https://doi.org/10.1111/his.13379
resource representing a document's title	Histopathology of Middle East respiratory syndrome coronovirus (MERS‐CoV) infection – clinicopathological and ultrastructural study
has PubMed Central identifier	PMC7165512
has PubMed identifier	28858401
schema:publication	Histopathology
resource representing a document's body	covid:f44fdbe9d42a0d80368becfb7cf4d8b41050e654#body_text
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