About: IRF7 in the Australian Black Flying Fox, Pteropus alecto: Evidence for a Unique Expression Pattern and Functional Conservation

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About: IRF7 in the Australian Black Flying Fox, Pteropus alecto: Evidence for a Unique Expression Pattern and Functional Conservation Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	IRF7 in the Australian Black Flying Fox, Pteropus alecto: Evidence for a Unique Expression Pattern and Functional Conservation
Creator	Wang, Lin-Fa Shi, Zhengli Zhou, Peng Green, Diane Monaghan, Paul Cowled, Chris Wu, Lijun Mansell, Ashley Baker, Michelle
Source	Medline; PMC
abstract	As the only flying mammal, bats harbor a number of emerging and re-emerging viruses, many of which cause severe diseases in humans and other mammals yet result in no clinical symptoms in bats. As the master regulator of the interferon (IFN)-dependent immune response, IFN regulatory factor 7 (IRF7) plays a central role in innate antiviral immunity. To explore the role of bat IRF7 in the regulation of the IFN response, we performed sequence and functional analysis of IRF7 from the pteropid bat, Pteropus alecto. Our results demonstrate that bat IRF7 retains the ability to bind to MyD88 and activate the IFN response despite unique changes in the MyD88 binding domain. We also demonstrate that bat IRF7 has a unique expression pattern across both immune and non-immune related tissues and is inducible by double-strand RNA. The broad tissue distribution of IRF7 may provide bats with an enhanced ability to rapidly activate the IFN response in a wider range of tissues compared to other mammals. The importance of IRF7 in antiviral activity against the bat reovirus, Pulau virus was confirmed by siRNA knockdown of IRF7 in bat cells resulting in enhanced viral replication. Our results highlight the importance of IRF7 in innate antiviral immunity in bats.
has issue date	2014-08-06(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0103875
bibo:pmid	25100081
has license	cc-by
sha1sum (hex)	f48a26496eec9f955c65e9d89305c4bc5df2718a
schema:url	https://doi.org/10.1371/journal.pone.0103875
resource representing a document's title	IRF7 in the Australian Black Flying Fox, Pteropus alecto: Evidence for a Unique Expression Pattern and Functional Conservation
has PubMed Central identifier	PMC4123912
has PubMed identifier	25100081
schema:publication	PLoS One
resource representing a document's body	covid:f48a26496eec9f955c65e9d89305c4bc5df2718a#body_text
is schema:about of	named entity 'EXPRESSION PATTERN' named entity 'EVIDENCE FOR' named entity 'virus' named entity 'mammals' named entity 'pteropid' named entity 'tissue' named entity 'inducible' named entity 'regulation' named entity 'retains' named entity 'innate' named entity 'binding domain' named entity 'Pteropus' named entity 'BLACK FLYING FOX' covid:arg/f48a26496eec9f955c65e9d89305c4bc5df2718a named entity 'INTERFERON ' named entity 'CLINICAL SYMPTOMS' named entity 'MAMMALS' named entity 'PTEROPUS ALECTO' named entity 'REOVIRUS' named entity 'ANTIVIRAL ACTIVITY' named entity 'RNA' named entity 'IMMUNE RESPONSE' named entity 'MYD88' named entity 'ENHANCED' named entity 'TISSUES' named entity 'MAMMAL' named entity 'BAT' named entity 'SEQUENCE' named entity 'FACTOR' named entity 'CAUSE' named entity 'BINDING' named entity 'VIRUS' named entity 'SEVERE' named entity 'ACTIVATE' named entity 'SIRNA' named entity 'BROAD' named entity 'IRF7' named entity 'UNIQUE' named entity 'DOUBLE' named entity 'DISEASES' named entity 'NON-' named entity 'RESPONSE' named entity 'FUNCTIONAL ANALYSIS' named entity 'FLYING' named entity 'CENTRAL' named entity 'IMMUNITY' named entity 'TO BIND TO' named entity 'REGULATOR' named entity 'RELATED' named entity 'RESULTS' named entity 'PLAYS' named entity 'DOMAIN' named entity 'CELLS' named entity 'ROLE' named entity 'CONSERVATION' named entity 'AUSTRALIAN' named entity 'HARBOR' named entity 'OUR' named entity 'UNIQUE' named entity 'FUNCTIONAL' named entity 'PERFORMED' named entity 'RAPIDLY' named entity 'EXPRESSION PATTERN' named entity 'NUMBER OF' named entity 'CONFIRMED BY' named entity 'COMPARED' named entity 'ANTIVIRAL' named entity 'IMMUNE' named entity 'STRAND' named entity 'TISSUE DISTRIBUTION' named entity 'DEPENDENT' named entity 'RANGE' named entity 'RESULTING IN'

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