About: The inhibitory effect of 7,7″-dimethoxyagastisflavone on the metastasis of melanoma cells via the suppression of F-actin polymerization

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About: The inhibitory effect of 7,7″-dimethoxyagastisflavone on the metastasis of melanoma cells via the suppression of F-actin polymerization Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The inhibitory effect of 7,7″-dimethoxyagastisflavone on the metastasis of melanoma cells via the suppression of F-actin polymerization
Creator	Wang, Yu-Shan Chan, Yi-Lin Chang, Jung Chen, Pin-Rong Chi, Kwan-Hwa Chung, Chen-Han Ho, Shu-Yi Hwang, Chia-Hsiang Ke, Chun-Yen Liao, Kuang-Wen Lin, Ching-Min Lin, Yu-Ling Tsai, Nu-Man Tsai, Yi-Hsuan Tzou, Shey-Cherng
Source	Medline; PMC
abstract	7,7″-Dimethoxyagastisflavone (DMGF), a biflavonoid isolated from Taxus × media cv. Hicksii, induces apoptotic and autophagic cell death. However, whether DMGF suppresses tumor metastasis is unclear. The aim of this study was to investigate the anti-metastatic activities of DMGF on the metastatic processes of melanoma cells in vivo and in vitro. A transwell assay showed that DMGF could effectively attenuate the motility of B16F10 cells, and the results of real-time PCR revealed that DMGF also suppressed the expressions of matrix metalloproteinase-2 (MMP-2). Moreover, DMGF did not influence tube formation but inhibited the migration of endothelial cells. Furthermore, animal models were used to monitor the effects of DMGF on tumor metastasis, and all models showed that DMGF significantly suppressed the metastatic behaviors of B16F10 cells, including intravasation, colonization, and invasion of the lymphatic duct. In addition, DMGF could also reduce the densities of the blood vessels in the tumor area in vivo. Further investigation of the molecular mechanisms of anti-metastatic activity revealed that DMGF can down-regulate the levels of key modulators of the Cdc42/Rac1 pathway to interfere in F-actin polymerization and suppress the formation of lamellipodia by reducing the phosphorylation of CREB. These data suggested that DMGF presents anti-metastatic activities in B16F10 melanoma cells. Here, we demonstrated that DMGF can inhibit the metastasis of highly invasive melanoma cancer cells through the down-regulation of F-actin polymerization. Considering these findings, DMGF may be further developed to serve as a chemoprevention drug for patients with metastatic melanoma.
has issue date	2016-07-30(xsd:dateTime)
bibo:doi	10.18632/oncotarget.10960
bibo:pmid	28947953
has license	cc-by
sha1sum (hex)	f4f0d1b957340175fd951c8fa9c27815dd589f26
schema:url	https://doi.org/10.18632/oncotarget.10960
resource representing a document's title	The inhibitory effect of 7,7″-dimethoxyagastisflavone on the metastasis of melanoma cells via the suppression of F-actin polymerization
has PubMed Central identifier	PMC5601121
has PubMed identifier	28947953
schema:publication	Oncotarget
resource representing a document's body	covid:f4f0d1b957340175fd951c8fa9c27815dd589f26#body_text
is schema:about of	named entity 'apoptotic' named entity 'motility' named entity 'investigation' named entity 'Further' named entity 'cell death' named entity 'tumor' named entity 'reduce' named entity 'inhibitory' named entity 'ISOLATED' named entity 'PATHWAY' named entity 'BUT' named entity 'INTRAVASATION' named entity 'MATRIX METALLOPROTEINASE-2' named entity 'MOTILITY' named entity 'ENDOTHELIAL CELLS' named entity 'ACTIVITIES' named entity 'ANTI-METASTATIC ACTIVITY' named entity 'LAMELLIPODIA' named entity 'INVESTIGATION' named entity 'SUPPRESS' named entity 'TO INVESTIGATE' named entity 'APOPTOTIC' named entity 'ASSAY' named entity 'SUPPRESSED' named entity 'ACTIN POLYMERIZATION' named entity 'CDC42' named entity 'IN VIVO' named entity 'RESULTS' named entity 'INVASION' named entity 'REDUCE' named entity 'MELANOMA CELLS' named entity 'INHIBITORY EFFECT' named entity 'METASTASIS' named entity 'FORMATION' named entity 'LYMPHATIC DUCT' named entity 'DID' named entity 'CREB' named entity 'MECHANISMS' named entity 'PROCESSES' named entity 'UNCLEAR' named entity 'COLONIZATION' named entity 'STUDY' named entity 'CELLS' named entity 'REGULATE' named entity 'IN VITRO' named entity 'TUBE FORMATION' named entity 'USED' named entity 'ACTIN POLYMERIZATION' named entity 'REAL-TIME PCR ' named entity 'REVEALED' named entity 'F-ACTIN' named entity 'B16F10' named entity 'PHOSPHORYLATION' named entity 'BEHAVIORS' named entity 'INTERFERE' named entity 'MODULATORS' named entity 'MIGRATION' named entity 'AREA' named entity 'MODELS' named entity 'MOLECULAR' named entity 'ATTENUATE' named entity 'TAXUS X MEDIA' named entity 'INFLUENCE' named entity 'MONITOR' named entity 'LEVELS' named entity 'INCLUDING' named entity 'DENSITIES'

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