About: Antigenic Cross-Reactivity between Severe Acute Respiratory Syndrome—Associated Coronavirus and Human Coronaviruses 229E and OC43

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About: Antigenic Cross-Reactivity between Severe Acute Respiratory Syndrome—Associated Coronavirus and Human Coronaviruses 229E and OC43 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Antigenic Cross-Reactivity between Severe Acute Respiratory Syndrome—Associated Coronavirus and Human Coronaviruses 229E and OC43
Creator	Yuen, Kwok-Yung Hao, Wei Che, Xiao-Yan Wen, Kun Wang, Ya-Di Cheng, Vincent Liao, Zhi-Yong Mei, Ya-Bo Qiu, Li-Wen Pan, Yu-Xian
source	Medline; PMC
abstract	Cross-reactivity between antibodies to different human coronaviruses (HCoVs) has not been systematically studied. By use of Western blot analysis, indirect immunofluorescence assay (IFA), and enzyme-linked immunosorbent assay (ELISA), antigenic cross-reactivity between severe acute respiratory syndrome (SARS)—associated coronavirus (SARS-CoV) and 2 HCoVs (229E and OC43) was demonstrated in immunized animals and human serum. In 5 of 11 and 10 of 11 patients with SARS, paired serum samples showed a ⩾4-fold increase in antibody titers against HCoV-229E and HCoV-OC43, respectively, by IFA. Overall, serum samples from convalescent patients who had SARS had a 1-way cross-reactivity with the 2 known HCoVs. Antigens of SARS-CoV and HCoV-OC43 were more cross-reactive than were those of SARS-CoV and HCoV-229E.
has issue date	2005-06-15(xsd:dateTime)
bibo:doi	10.1086/430355
bibo:pmid	15897988
has license	no-cc
sha1sum (hex)	f5126a5111f9c53cf3f621c9ab6d54b6b57ab95a
schema:url	https://doi.org/10.1086/430355
resource representing a document's title	Antigenic Cross-Reactivity between Severe Acute Respiratory Syndrome—Associated Coronavirus and Human Coronaviruses 229E and OC43
has PubMed Central identifier	PMC7109809
has PubMed identifier	15897988
schema:publication	J Infect Dis
resource representing a document's body	covid:f5126a5111f9c53cf3f621c9ab6d54b6b57ab95a#body_text
is schema:about of	named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'titers' named entity 'demonstrated' named entity 'Overall' named entity 'serum' named entity 'REACTIVITY' named entity 'CONVALESCENT' covid:arg/f5126a5111f9c53cf3f621c9ab6d54b6b57ab95a named entity 'HCOV-OC43' named entity 'HUMAN' named entity 'ANTIBODIES' named entity 'PATIENTS' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'FOLD INCREASE' named entity '229E' named entity 'OC43' named entity 'HCOV-229E' named entity 'ANTIGENS' named entity 'SARS-COV' named entity 'ASSOCIATED' named entity 'CORONAVIRUS' named entity 'HUMAN' named entity 'CROSS' named entity 'CORONAVIRUSES' named entity 'CROSS' named entity 'IMMUNOFLUORESCENCE ASSAY' named entity 'ENZYME-LINKED IMMUNOSORBENT ASSAY' named entity 'DEMONSTRATED' named entity 'INDIRECT IMMUNOFLUORESCENCE' named entity 'ANTIBODY TITERS' named entity 'IFA' named entity 'KNOWN' named entity 'ASSOCIATED' named entity 'USE OF' named entity 'SARS' named entity 'OVERALL' named entity 'IMMUNIZED' named entity 'OC43' named entity 'CORONAVIRUS' named entity 'ANIMALS' named entity 'SERUM' named entity 'WESTERN BLOT ANALYSIS' named entity '834' named entity 'SAMPLES' named entity 'PAIRED' named entity 'DIFFERENT' named entity 'REACTIVITY' named entity 'WAY' named entity 'HUMAN SERUM' named entity 'CORONAVIRUSES' named entity 'CROSS-REACTIVE' named entity 'human coronaviruses' named entity 'indirect immunofluorescence' named entity 'coronavirus' named entity 'cross-reactivity' named entity 'studied' named entity 'SARS-CoV' named entity 'cross-reactivity' named entity 'HCoV-OC43' named entity 'enzyme-linked immunosorbent assay' named entity 'HCoV-OC43' named entity 'Cross-reactivity' named entity 'immunofluorescence assay' named entity 'OC43' named entity 'antibodies' named entity 'SARS-CoV' named entity 'serum samples' named entity '229E' named entity 'primer pairs' named entity 'filtrate' named entity 'cross-reactivity' named entity 'HCoV-OC43'

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