About: Characterization of acute kidney injury in critically ill patients with severe coronavirus disease 2019

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About: Characterization of acute kidney injury in critically ill patients with severe coronavirus disease 2019 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Characterization of acute kidney injury in critically ill patients with severe coronavirus disease 2019
Creator	Joannes-Boyau, Olivier Guisset, Olivier Rozé, Hadrien Camou, Fabrice Combe, Christian Mourissoux, Gaelle Bats, Marie-Lise Boyer, Alexandre Bui, Hoang-Nam Clouzeau, Benjamin Dabernat, Sandrine Dewitte, Antoine Fleureau, Catherine Garric, Antoine Gruson, Didier Issa, Nahema Orieux, Arthur Petit, Laurent Pillet, Odile Prevel, Renaud Rigothier, Claire Sazio, Charline Vargas, Frederic Bastien Rubin, Sé Dric Carrié, Cé
Source	Medline; PMC
abstract	BACKGROUND: Coronavirus disease 2019 (COVID-19)-associated acute kidney injury (AKI) frequency, severity and characterization in critically ill patients has not been reported. METHODS: Single-centre cohort performed from 3 March 2020 to 14 April 2020 in four intensive care units in Bordeaux University Hospital, France. All patients with COVID-19 and pulmonary severity criteria were included. AKI was defined using Kidney Disease: Improving Global Outcomes (KDIGO) criteria. A systematic urinary analysis was performed. The incidence, severity, clinical presentation, biological characterization (transient versus persistent AKI; proteinuria, haematuria and glycosuria) and short-term outcomes were evaluated. RESULTS: Seventy-one patients were included, with basal serum creatinine (SCr) of 69 ± 21 µmol/L. At admission, AKI was present in 8/71 (11%) patients. Median [interquartile range (IQR)] follow-up was 17 (12–23) days. AKI developed in a total of 57/71 (80%) patients, with 35% Stage 1, 35% Stage 2 and 30% Stage 3 AKI; 10/57 (18%) required renal replacement therapy (RRT). Transient AKI was present in only 4/55 (7%) patients and persistent AKI was observed in 51/55 (93%). Patients with persistent AKI developed a median (IQR) urine protein/creatinine of 82 (54–140) (mg/mmol) with an albuminuria/proteinuria ratio of 0.23 ± 20, indicating predominant tubulointerstitial injury. Only two (4%) patients had glycosuria. At Day 7 after onset of AKI, six (11%) patients remained dependent on RRT, nine (16%) had SCr >200 µmol/L and four (7%) had died. Day 7 and Day 14 renal recovery occurred in 28% and 52%, respectively. CONCLUSION: Severe COVID-19-associated AKI is frequent, persistent, severe and characterized by an almost exclusive tubulointerstitial injury without glycosuria.
has issue date	2020-06-06(xsd:dateTime)
bibo:doi	10.1093/ckj/sfaa099
bibo:pmid	32695326
has license	cc-by-nc
sha1sum (hex)	f513e14f99dfeb964203c42b0009374c9c49908e
schema:url	https://doi.org/10.1093/ckj/sfaa099
resource representing a document's title	Characterization of acute kidney injury in critically ill patients with severe coronavirus disease 2019
has PubMed Central identifier	PMC7314187
has PubMed identifier	32695326
schema:publication	Clin Kidney J
resource representing a document's body	covid:f513e14f99dfeb964203c42b0009374c9c49908e#body_text
is schema:about of	named entity 'severe' named entity 'SEVERITY' named entity 'Background' named entity 'critically ill' named entity 'patients' named entity 'coronavirus disease 2019' named entity 'Haematuria' named entity 'albuminuria' named entity 'immunosuppressed' named entity 'inflammation' named entity 'ICU' named entity 'C-reactive protein' named entity 'norepinephrine' named entity 'AKI' named entity 'critically ill patients' named entity 'Health-care' named entity 'ICU' named entity 'Pearson's Chi-squared test' named entity 'fraction of inspired oxygen' named entity 'COVID-19' named entity 'ICU' named entity 'diuresis' named entity 'AKI' named entity 'ICU' named entity 'intensive care unit' named entity 'Epidemiology' named entity 'mmol/L' named entity 'foley catheter' named entity 'anuria' named entity 'epidemic' named entity 'China' named entity 'intensive care unit' named entity 'acute pulmonary oedema' named entity 'COVID-19' named entity 'RRT' named entity 'biochemical' named entity 'invasive mechanical ventilation' named entity 'haematologic' named entity 'Serum creatinine' named entity 'computed tomography' named entity 'pretest' named entity 'AKI' named entity 'AKI' named entity 'parenteral nutrition' named entity 'severe acute respiratory syndrome coronavirus 2' named entity 'ICUs' named entity 'arterial partial pressure of oxygen' named entity 'oxygen' named entity 'Corbeil Essonnes' named entity 'AKI' named entity 'AKI' named entity 'AKI' named entity 'ferritin' named entity 'co-occurrence' named entity 'Kaplan-Meier curve' named entity 'creatinine' named entity 'COVID-19'

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