About: Coronavirus and PARP expression dysregulate the NAD Metabolome: a potentially actionable component of innate immunity

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About: Coronavirus and PARP expression dysregulate the NAD Metabolome: a potentially actionable component of innate immunity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Coronavirus and PARP expression dysregulate the NAD Metabolome: a potentially actionable component of innate immunity
Creator	Perlman, Stanley Fehr, Anthony Cohen, Michael Alhammad, Yousef Brenner, Charles Heer, Collin Sanderson, Daniel Schmidt, Mark Trammell, Samuel Voth, Lynden
Source	BioRxiv; Medline; PMC
abstract	SARS-CoV-2 is a coronavirus (CoV) and cause of COVID-19, which is much more lethal in older people and those with comorbid conditions for unknown reasons. Innate immune responses to CoVs are initiated by recognition of double-stranded RNA and induction of interferon, which turns on a gene expression program that inhibits viral replication. Here we show that SARS-CoV-2 infection of cells, ferrets and a person strikingly dysregulates the NAD gene set by inducing a set of PARP family members that includes enzymes required for the innate immune response to CoVs. CoV infection also induces a severe attack on host cell NAD. Overexpression of one induced enzyme, PARP10, is sufficient to depress host NAD. Gene expression and pharmacological data suggest that boosting NAD through the nicotinamide and nicotinamide riboside kinase pathways may restore antiviral PARP functions to support innate immunity to CoVs, whereas PARP1,2 inhibition does not restore PARP10 activity.
has issue date	2020-04-30(xsd:dateTime)
bibo:doi	10.1101/2020.04.17.047480
bibo:pmid	32511303
has license	no-cc
sha1sum (hex)	f54c22d3ddb0fe120528c402989f40b6effd3e55
schema:url	https://doi.org/10.1101/2020.04.17.047480
resource representing a document's title	Coronavirus and PARP expression dysregulate the NAD Metabolome: a potentially actionable component of innate immunity
has PubMed Central identifier	PMC7217258
has PubMed identifier	32511303
schema:publication	bioRxiv
resource representing a document's body	covid:f54c22d3ddb0fe120528c402989f40b6effd3e55#body_text
is schema:about of	named entity 'Innate' named entity 'recognized' named entity 'immunity' named entity 'expression' named entity 'CORONAVIRUSES' named entity '18 hours' named entity 'nicotinamide riboside' named entity 'NAD' named entity 'C57BL/6' named entity 'NADP' named entity 'downregulated' named entity 'virus' named entity 'IFN' named entity 'statistically significant' named entity 'metabolome' named entity 'biosynthetic' named entity 'NAD' named entity 'metabolome' named entity 'NAD' named entity 'lung' named entity 'NAD' named entity 'gene expression' named entity 'transcription' named entity 'infection' named entity 'acute respiratory distress syndrome' named entity 'metabolome' named entity 'IFN' named entity 'coenzymes' named entity 'Transfection' named entity 'NAD' named entity 'ferret' named entity 'infection' named entity 'NAD' named entity 'MOI' named entity 'PARP12' named entity 'depression' named entity 'nicotinic acid' named entity 'intermediates' named entity 'COVID-19' named entity 'viruses' named entity 'antiviral' named entity 'NAD' named entity 'MOI' named entity 'biosynthetic' named entity 'ADP' named entity 'L929' named entity 'obesity' named entity 'NAD' named entity 'nerve damage' named entity 'RNAseq' named entity 'NAD' named entity 'MOI' named entity 'infectivity' named entity 'enzymatic activities' named entity 'data set' named entity 'enterocytes' named entity 'SARS-CoV-2' named entity 'antiviral' named entity 'Zika virus infection' named entity 'amino acid' named entity 'biosynthetic' named entity 'nmol' named entity 'metabolome' named entity 'genomes' named entity 'tryptophan' named entity 'infection' named entity 'COVID-19' named entity 'PARP8' named entity 'MOI' named entity 'Nsp3' named entity 'pharmacologically' named entity 'metabolism'

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