About: Comparison of molecular detection methods for pertussis in children during a state-wide outbreak

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Comparison of molecular detection methods for pertussis in children during a state-wide outbreak
Creator	Adler, A Berry, J Buccat, A Englund, J Kronman, M Qin, X Rich, S Xu, M Zerr, D
source	Medline; PMC
abstract	A state-wide pertussis outbreak occurred in Washington during the winter–spring months of 2012, concurrent with respiratory viral season. We compared performance characteristics of a laboratory-developed pertussis PCR (LD-PCR for Bordetella pertussis, Bordetella parapertussis, and Bordetella holmesii) and rapid multiplex PCR (RM-PCR) for respiratory viruses (FilmArray™, BioFire, B. pertussis data unblinded following FDA approval post outbreak). We analyzed three cohorts of patients using physician testing orders as a proxy for clinical suspicion for pertussis or respiratory viruses: Cohort 1, tested by LD-PCR for pertussis pathogens only by nasopharyngeal swab; Cohort 2, by RM-PCR for respiratory viruses only by mid-nasal turbinate swab; and Cohort 3, by both methods. B. pertussis was detected in a total of 25 of the 490 patients in Cohort 3 in which LD-PCR detected 20/25 (80 %) cases and the RM-PCR detected 24/25 (96 %; p = 0.2). Pertussis pathogens were detected in 21/584 (3.6 %) of samples from Cohort 1 where clinicians had a relatively strong suspicion for pertussis. In contrast, B. pertussis was detected in only 4/3071 (0.1 %) specimens from Cohort 2 where suspicion for pertussis was lower (p < 0.001 for comparison with Cohort 1). In summary, the two laboratory methods were comparable for the detection of B. pertussis.
has issue date	2016-04-27(xsd:dateTime)
bibo:doi	10.1186/s12941-016-0142-4
bibo:pmid	27121506
has license	cc-by
sha1sum (hex)	f54e577394738498bde347596b1dd5b1156d235d
schema:url	https://doi.org/10.1186/s12941-016-0142-4
resource representing a document's title	Comparison of molecular detection methods for pertussis in children during a state-wide outbreak
has PubMed Central identifier	PMC4847268
has PubMed identifier	27121506
schema:publication	Ann Clin Microbiol Antimicrob
resource representing a document's body	covid:f54e577394738498bde347596b1dd5b1156d235d#body_text
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