About: Chronic oxytocin-driven alternative splicing of CRFR2α induces anxiety

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About: Chronic oxytocin-driven alternative splicing of CRFR2α induces anxiety Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Chronic oxytocin-driven alternative splicing of CRFR2α induces anxiety
Creator	Neumann, Inga Winter, Julia Jurek, Benjamin Berger, Ilona Bianchi, Marta Bludau, Anna Bosch, Oliver Hartmann, Finn Kuffner, Kerstin Langgartner, Dominik Meyer, Magdalena Peters, Sebastian Reber, Stefan Royer, Melanie Schmidtner, Anna Slattery, David Stang, Simone Van Den Burg, Erwin
source	BioRxiv
abstract	Recently, oxytocin (OXT) has generated considerable interest as potential treatment for psychiatric disorders, including general anxiety disorder or autism spectrum disorder. Therefore, knowledge on the involved molecular processes downstream of OXT receptor (OXTR) activation is indispensable. We reveal that alternative splicing of corticotropin releasing factor receptor 2α (CRFR2α) parallels increased anxiety-like behavior following chronic OXT treatment, contrasting the well-known anxiolysis of acute OXT. In detail, chronic OXT shifts the splicing ratio between membrane-bound (mCRFR2α) and soluble CRFR2α (sCRFR2α) in favor of the latter via ERK1/2-MEF2A signaling. Targeted manipulations of Crfr2α splicing mimic the effect of chronic OXT, confirming its role in the regulation of anxiety-like behavior. Furthermore, chronic OXT triggers cytoplasmic distribution and extracellular release of sCRFR2α into the cerebrospinal fluid, with sCRFR2α levels positively correlating with anxiety-like behavior. Concluding, the dichotomy between anxiolytic mCRFR2α and anxiogenic sCRFR2α is the basis for the deleterious effects of chronic OXT on anxiety. Graphical Abstract
has issue date	2020-08-19(xsd:dateTime)
bibo:doi	10.1101/2020.08.19.255844
has license	biorxiv
sha1sum (hex)	f55e0e0eeb8c0d720b73ed1e68fb766da7ebe398
schema:url	https://doi.org/10.1101/2020.08.19.255844
resource representing a document's title	Chronic oxytocin-driven alternative splicing of CRFR2α induces anxiety
schema:publication	bioRxiv
resource representing a document's body	covid:f55e0e0eeb8c0d720b73ed1e68fb766da7ebe398#body_text
is schema:about of	named entity 'MIMIC' named entity 'GENERAL' named entity 'INCLUDING' named entity 'cytoplasmic' named entity 'corticotropin releasing factor' named entity 'MEF2A' named entity 'increased anxiety' named entity 'cerebrospinal fluid' named entity 'receptor' named entity 'receptor' named entity 'molecular processes' named entity 'alternative splicing' named entity 'alternative splicing' named entity 'anxiolytic' named entity 'oxytocin' named entity 'anxiogenic' named entity 'general anxiety disorder' named entity 'ANXIETY-LIKE BEHAVIOR' named entity 'CONTRASTING' named entity 'ALTERNATIVE SPLICING' named entity 'ERK1/2' named entity 'anxiety' named entity 'anxiolysis' named entity 'anxiety' named entity 'SPLICING' named entity 'PROCESSES' named entity 'SOLUBLE' named entity 'PSYCHIATRIC DISORDERS' named entity 'OXYTOCIN' named entity 'anxiety' named entity 'extracellular' named entity 'OXTR' named entity 'oxytocin' covid:arg/f55e0e0eeb8c0d720b73ed1e68fb766da7ebe398 named entity 'autism spectrum disorder' named entity 'CHRONIC' named entity 'FOLLOWING' named entity 'AUTISM SPECTRUM DISORDER' named entity 'BOUND' named entity 'TREATMENT' named entity 'MEF2A' named entity 'ANXIETY DISORDER' named entity 'SHIFTS' named entity 'ANXIETY' named entity 'psychiatric disorders' named entity 'membrane-bound' named entity 'ITS' named entity 'INTEREST' named entity 'ANXIETY' named entity 'EXTRACELLULAR' named entity 'GENERATED' named entity 'RATIO' named entity 'REVEAL' named entity 'ANXIOLYSIS' named entity 'DELETERIOUS' named entity 'INDISPENSABLE' named entity 'ANXIOGENIC' named entity 'EFFECT' named entity 'ERK1' named entity 'CORTICOTROPIN RELEASING FACTOR' named entity 'RECEPTOR' named entity 'ACTIVATION' named entity 'ALTERNATIVE SPLICING' named entity 'CHRONIC' named entity 'ANXIOLYTIC' named entity 'REGULATION' named entity 'INCREASED ANXIETY'

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