About: A phylogenomic data-driven exploration of viral origins and evolution

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: A phylogenomic data-driven exploration of viral origins and evolution Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	A phylogenomic data-driven exploration of viral origins and evolution
Creator	Caetano-Anollés, Gustavo Nasir, Arshan
source	Medline; PMC
abstract	The origin of viruses remains mysterious because of their diverse and patchy molecular and functional makeup. Although numerous hypotheses have attempted to explain viral origins, none is backed by substantive data. We take full advantage of the wealth of available protein structural and functional data to explore the evolution of the proteomic makeup of thousands of cells and viruses. Despite the extremely reduced nature of viral proteomes, we established an ancient origin of the “viral supergroup” and the existence of widespread episodes of horizontal transfer of genetic information. Viruses harboring different replicon types and infecting distantly related hosts shared many metabolic and informational protein structural domains of ancient origin that were also widespread in cellular proteomes. Phylogenomic analysis uncovered a universal tree of life and revealed that modern viruses reduced from multiple ancient cells that harbored segmented RNA genomes and coexisted with the ancestors of modern cells. The model for the origin and evolution of viruses and cells is backed by strong genomic and structural evidence and can be reconciled with existing models of viral evolution if one considers viruses to have originated from ancient cells and not from modern counterparts.
has issue date	2015-09-25(xsd:dateTime)
bibo:doi	10.1126/sciadv.1500527
bibo:pmid	26601271
has license	cc-by-nc
sha1sum (hex)	f601587d47e1c6f922247d571299bb21624ac0da
schema:url	https://doi.org/10.1126/sciadv.1500527
resource representing a document's title	A phylogenomic data-driven exploration of viral origins and evolution
has PubMed Central identifier	PMC4643759
has PubMed identifier	26601271
schema:publication	Sci Adv
resource representing a document's body	covid:f601587d47e1c6f922247d571299bb21624ac0da#body_text
is schema:about of	named entity 'modern' named entity 'backed' named entity 'data' named entity 'universal' named entity 'Although' named entity 'evolution' named entity 'hypotheses' named entity 'wealth' named entity 'exploration' named entity 'models' named entity 'cellular' named entity 'viruses' named entity 'evidence' named entity 'structural' named entity 'genomes' named entity 'supergroup' named entity 'proteomic' named entity 'The origin' named entity 'horizontal transfer' named entity 'genetic information' named entity 'horizontal transfer' named entity 'viruses' named entity 'proteomes' named entity 'viruses' named entity 'phylogenomic' named entity 'structural domains' named entity 'parasites' named entity 'Viruses' named entity 'plasmids' named entity 'virion' named entity 'viruses' named entity 'viruses' named entity 'viruses' named entity 'evolution' named entity 'HK97' named entity 'virus' named entity 'homologs' named entity 'evolutionarily related' named entity 'ecological niche' named entity 'virus' named entity 'RNA genomes' named entity 'ribosomal' named entity 'Fibrobacter' named entity 'SARS' named entity 'virion' named entity 'FSF' named entity 'host tropism' named entity 'superkingdoms' named entity 'glycoproteins' named entity 'homologous' named entity 'jelly-roll' named entity 'phylogenetic distance matrix' named entity 'proteomes' named entity 'morphotype' named entity 'RNA-dependent RNA polymerase' named entity 'parsimonious' named entity 'binary fission' named entity 'proteomes' named entity 'FSFs' named entity 'superkingdoms' named entity 'eukaryotic' named entity 'viral proteins' named entity 'evolution' named entity 'violin' named entity 'dsRNA' named entity 'proteomes' named entity 'probability' named entity 'comparative genomic' named entity 'SCOP' named entity 'RNA' named entity 'deoxyribonucleotide' named entity 'evolutionary patterns' named entity 'HGT' named entity 'giant viruses' named entity 'HGT' named entity 'viral proteins' named entity 'class II' named entity 'ICTV' named entity 'yetto' named entity 'host cells'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software