About: Upregulation of CD47 Is a Host Checkpoint Response to Pathogen Recognition

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About: Upregulation of CD47 Is a Host Checkpoint Response to Pathogen Recognition Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Upregulation of CD47 Is a Host Checkpoint Response to Pathogen Recognition
Creator	Carmody, Aaron Markovic, Maxim Banaei, Niaz Hasenkrug, Kim Lang, Karl Messer, Ronald Monack, Denise Peterson, Karin Weissman, Irving Woods, Tyson Adomati, Tom Davis, Mark Ahmed, Aijaz Nguyen, Thai Ab, Carmody Ac, Bohrer Angel, Cesar Bear, Laughing Bj, Fram Bohrer, Andrea Castro, Ehydel Cham, Lamin Corey, Daniel Cw, Winkler Dm, Monack Dulgeroff, Torrez Fram, Benjamin Galloway, Sarah Gars, Eric Glenn, Jeffrey Hansen, Paige Hasenkrug, Michaela Js, Glenn Kalluru, Raja Kd, Mayer-Barber Ke, Peterson Kortmann, Gars Kortmann, Jens Ks, Lang Lb, Cham Lopez, Angel Mayer-Barber, Katrin Mc, Tal Mm, Davis Myers, Lara Pham, Ed Rajadas, Jayakumar Rj, Messer Rs, Kalluru Sahoo, Debashis Ta, Woods Tal, Michal Wagh, Dhananjay Winkler, Clayton Yiu, Ying Yy, Yiu
Source	Medline; PMC
abstract	It is well understood that the adaptive immune response to infectious agents includes a modulating suppressive component as well as an activating component. We now show that the very early innate response also has an immunosuppressive component. Infected cells upregulate the CD47 “don’t eat me” signal, which slows the phagocytic uptake of dying and viable cells as well as downstream antigen-presenting cell (APC) functions. A CD47 mimic that acts as an essential virulence factor is encoded by all poxviruses, but CD47 expression on infected cells was found to be upregulated even by pathogens, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), that encode no mimic. CD47 upregulation was revealed to be a host response induced by the stimulation of both endosomal and cytosolic pathogen recognition receptors (PRRs). Furthermore, proinflammatory cytokines, including those found in the plasma of hepatitis C patients, upregulated CD47 on uninfected dendritic cells, thereby linking innate modulation with downstream adaptive immune responses. Indeed, results from antibody-mediated CD47 blockade experiments as well as CD47 knockout mice revealed an immunosuppressive role for CD47 during infections with lymphocytic choriomeningitis virus and Mycobacterium tuberculosis. Since CD47 blockade operates at the level of pattern recognition receptors rather than at a pathogen or antigen-specific level, these findings identify CD47 as a novel potential immunotherapeutic target for the enhancement of immune responses to a broad range of infectious agents.
has issue date	2020-06-23(xsd:dateTime)
bibo:doi	10.1128/mbio.01293-20
bibo:pmid	32576678
has license	no-cc
sha1sum (hex)	f60501898d7d50a849c74ff2e821e3448bf84346
schema:url	https://doi.org/10.1128/mbio.01293-20
resource representing a document's title	Upregulation of CD47 Is a Host Checkpoint Response to Pathogen Recognition
has PubMed Central identifier	PMC7315125
has PubMed identifier	32576678
schema:publication	mBio
resource representing a document's body	covid:f60501898d7d50a849c74ff2e821e3448bf84346#body_text
is schema:about of	named entity 'FUNCTIONS' named entity 'DYING' named entity 'FOUND' named entity 'INFECTED' named entity 'ACTIVATING' named entity 'INCLUDING' named entity 'CD47' named entity 'VIRULENCE FACTOR' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2' named entity 'proinflammatory cytokines' named entity 'dendritic cells' named entity 'antigen-presenting cell' named entity 'phagocytic uptake' named entity 'adaptive immune response' named entity 'pathogen recognition receptors' named entity 'pathogens' named entity 'Pathogen' named entity 'severe acute respiratory syndrome coronavirus 2' named entity 'upregulation' named entity 'innate response' named entity 'Upregulation' named entity 'CD47' named entity 'endosomal' named entity 'SARS-CoV-2' named entity 'CD47' named entity 'CD47'

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