About: Restriction of measles virus gene expression in acute and subacute encephalitis of Lewis rats

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Restriction of measles virus gene expression in acute and subacute encephalitis of Lewis rats
Creator	Cattaneo, Roberto Baczko, Knut Billeter, Martin Schneider-Schaulies, Sibylle Liebert, Uwe Volker Ter Meulen, And
source	Elsevier; Medline; PMC
abstract	Abstract Measles virus (MV) replication in brain tissue of Lewis rats with acute (AE) and subacute (SAME) encephalitis was characterized by biochemical techniques. Messenger RNAs specific for measles virus nucleocapsid (N), phospho (P)-, matrix (M), fusion (F), and haemagglutinin (H) protein were detected in all brain extracts examined. The quantity of the individual MV mRNA species was quite different in comparison to lytically infected Vero cells. A steep gradient of MV transcripts was found in brain tissue which is most likely due to strongly attenuated transcription of mRNAs along the viral genome, representing particularly low transcription of the glycoprotein genes. In addition, in vitro translation assays only revealed synthesis of N and P protein in consistent fashion. The mRNAs for the glycoproteins did not direct the synthesis of detectable viral proteins whereas the M mRNA revealed some activity in animals with AE. The data indicate a strong restriction of the MV envelope gene expression in infected brain tissue, which is independent of the incubation time and type of the central nervous system (CNS) disease. This phenomenon which is similar to the findings observed in measles inclusion body encephalitis and subacute sclerosing panencephalitis suggest that host factors may initially be responsible for the initiation of transcriptional and translational alterations.
has issue date	1989-08-31(xsd:dateTime)
bibo:doi	10.1016/0042-6822(89)90622-3
bibo:pmid	2788328
has license	els-covid
sha1sum (hex)	f62387b6af7c436040d7c8ef1226865ff69e357e
schema:url	https://doi.org/10.1016/0042-6822%2889%2990622-3
resource representing a document's title	Restriction of measles virus gene expression in acute and subacute encephalitis of Lewis rats
has PubMed Central identifier	PMC7118891
has PubMed identifier	2788328
schema:publication	Virology
resource representing a document's body	covid:f62387b6af7c436040d7c8ef1226865ff69e357e#body_text
is schema:about of	named entity 'Restriction' named entity 'Measles' named entity 'SUBACUTE' named entity 'ENCEPHALITIS' named entity 'RESTRICTION' named entity 'RATS' named entity 'ACUTE' named entity 'GENE EXPRESSION' named entity 'MEASLES VIRUS' named entity 'LEWIS' named entity 'Lewis' named entity 'scintillation counting' named entity 'lane 8' named entity 'SAME' named entity 'bone marrow' named entity 'Amersham' named entity 'brain tissue' named entity 'lytically' named entity 'infection' named entity 'sequencing gel' named entity 'protein' named entity 'acute encephalitis' named entity 'mutation' named entity 'marker proteins' named entity 'fmol' named entity 'RNA' named entity 'antibodies' named entity 'RNAs' named entity 'lane 8' named entity 'homology' named entity 'mRNAs' named entity 'inoculation' named entity 'Vero cells' named entity 'weanling' named entity 'weanling' named entity 'brain tissue' named entity 'cloned' named entity 'monospecific' named entity 'rat' named entity 'phenol extraction' named entity 'mRNAs' named entity 'brain cells' named entity '3' end' named entity 'monocistronic' named entity 'CSF' named entity 'immunoprecipitated' named entity 'mRNAs' named entity 'mRNAs' named entity 'immunoprecipitated' named entity 'RNA' named entity 'RNA' named entity 'Vero cells' named entity 'pathogenetic' named entity 'formamide' named entity 'incubation period' named entity 'Bellini' named entity 'formaldehyde' named entity 'open reading frames' named entity 'infection' named entity 'cerebral hemisphere' named entity 'cGMP' named entity 'spinal cord' named entity 'CNS' named entity 'gene expression' named entity 'nuclease' named entity 'SAME' named entity 'protein' named entity 'primer extension' named entity 'transcriptional' named entity 'RNA' named entity 'noncoding regions' named entity 'stop codon' named entity 'Vero' named entity 'GC content' named entity 'gray matter' named entity 'formamide'

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