About: Susceptibility of swine cells and domestic pigs to SARS-CoV-2

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About: Susceptibility of swine cells and domestic pigs to SARS-CoV-2 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Susceptibility of swine cells and domestic pigs to SARS-CoV-2
Creator	Feldmann, Heinz Henningson, Jamie Ma, Wenjun Kwon, Taeyong Morozov, Igor Balasuriya, Udeni Richt, Juergen Indran, Sabarish Artiaga, Bianca Balaraman, Velmurugan Bold, Dashzeveg Gaudreault, Natasha Madden, Daniel Meekins, David Trujillo, Jessie
Source	BioRxiv; Medline
abstract	The emergence of SARS-CoV-2 has resulted in an ongoing global pandemic with significant morbidity, mortality, and economic consequences. The susceptibility of different animal species to SARS-CoV-2 is of concern due to the potential for interspecies transmission, and the requirement for pre-clinical animal models to develop effective countermeasures. In the current study, we determined the ability of SARS-CoV-2 to (i) replicate in porcine cell lines, (ii) establish infection in domestic pigs via experimental oral/intranasal/intratracheal inoculation, and (iii) transmit to co-housed naive sentinel pigs. SARS-CoV-2 was able to replicate in two different porcine cell lines with cytopathic effects. Interestingly, none of the SARS-CoV-2-inoculated pigs showed evidence of clinical signs, viral replication or SARS-CoV-2-specific antibody responses. Moreover, none of the sentinel pigs displayed markers of SARS-CoV-2 infection. These data indicate that although different porcine cell lines are permissive to SARS-CoV-2, five-week old pigs are not susceptible to infection via oral/intranasal/intratracheal challenge. Pigs are therefore unlikely to be significant carriers of SARS-CoV-2 and are not a suitable pre-clinical animal model to study SARS-CoV-2 pathogenesis or efficacy of respective vaccines or therapeutics.
has issue date	2020-08-16(xsd:dateTime)
bibo:doi	10.1101/2020.08.15.252395
bibo:pmid	32817946
has license	biorxiv
sha1sum (hex)	f6333c6081b70c4fdca2eedad30adcde05d01e8e
schema:url	https://doi.org/10.1101/2020.08.15.252395
resource representing a document's title	Susceptibility of swine cells and domestic pigs to SARS-CoV-2
has PubMed identifier	32817946
schema:publication	bioRxiv
resource representing a document's body	covid:f6333c6081b70c4fdca2eedad30adcde05d01e8e#body_text
is schema:about of	named entity 'inoculated' named entity 'naive' named entity 'morbidity' named entity 'SARS-CoV-2' named entity 'potential' named entity 'vaccines' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity '28I' named entity 'EFFICACY' named entity 'GLOBAL' named entity 'SARS-COV-2 PATHOGENESIS' named entity 'cytopathic' named entity 'consequences' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'sentinel' named entity 'specific' named entity 'intranasal' named entity 'intratracheal' named entity 'SARS-CoV-2' named entity 'sentinel' named entity 'pandemic' named entity 'domestic pigs' named entity 'porcine' named entity 'infection' named entity 'intratracheal' named entity 'cell lines' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'vaccines' named entity 'clinical signs' named entity 'infection' named entity 'animal species' named entity 'SARS-CoV-2' named entity 'swine' named entity 'swine' named entity 'develop' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'lung' named entity 'respiratory disease' named entity 'IgG' named entity 'infection' named entity 'RT-qPCR' named entity 'histopathological' named entity 'cell culture' named entity 'cell lines' named entity 'Betacoronavirus' named entity 'infectivity' named entity 'SARS-CoV-2' named entity 'porcine' named entity 'tissue sections' named entity '1, 2' named entity 'SARS-CoV-2' named entity 'porcine' named entity 'Lungs' named entity 'gene' named entity 'pathology' named entity 'inoculation' named entity 'lungs' named entity 'inoculation' named entity 'SARS-CoV-2' named entity 'lysis' named entity 'viral RNA' named entity 'rodent models' named entity 'pig'

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