About: Fatal Outcomes of COVID-19 in Patients with Severe Acute Kidney Injury

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Fatal Outcomes of COVID-19 in Patients with Severe Acute Kidney Injury
Creator	Kim, Yong-Lim Lee, Jaehee Seo, Hyewon Chang, Hyun-Ha Kim, Shin-Woo Kwon, Ki Cho, Jang-Hee Choi, Ji-Young Jeon, Yena Jung, Hee-Yeon Kim, Chan-Duck Lee, Yong-Hoon Lim, Jeong-Hoon Park, Sun-Hee
Source	Medline; PMC
abstract	The outcome of coronavirus disease 2019 (COVID-19) is associated with organ damage; however, the information about the relationship between acute kidney injury (AKI) and COVID-19 is still rare. We evaluated the clinical features and prognosis of COVID-19 patients with AKI according to the AKI severity. Medical data of hospitalized COVID-19 patients in two university-based hospitals during an outbreak in Daegu, South Korea, were retrospectively analyzed. AKI and its severity were defined according to the Acute Kidney Injury Network. Of the 164 hospitalized patients with COVID-19, 30 patients (18.3%) had AKI; 14, 4, and 12 patients had stage 1, 2, and 3, respectively. The median age was significantly higher in AKI patients than in non-AKI patients (75.5 vs. 67.0 years, p = 0.005). There were 17 deaths (56.7%) among AKI patients; 4 (28.6%), 1 (25.0%), and 12 (100.0%), respectively. In-hospital mortality was higher in AKI patients than in non-AKI patients (56.7% vs. 20.8%, p < 0.001). After adjusting for potential confounding factors, stage 3 AKI was associated with higher mortality than either non-AKI or stage 1 AKI (hazard ratio (HR) = 3.62 (95% confidence interval (CI) = 1.75–7.48), p = 0.001; HR = 15.65 (95% CI = 2.43–100.64), p = 0.004). Among the AKI patients, acute respiratory distress syndrome and low serum albumin on admission were considered independent risk factors for stage 3 AKI (both p < 0.05). Five patients with stage 3 AKI underwent dialysis and eventually died. In conclusion, COVID-19 patients with severe AKI had fatal outcomes.
has issue date	2020-06-03(xsd:dateTime)
bibo:doi	10.3390/jcm9061718
bibo:pmid	32503180
has license	cc-by
sha1sum (hex)	f65899229ad904db5a2ad32dcc9eb0a7cbb38c04
schema:url	https://doi.org/10.3390/jcm9061718
resource representing a document's title	Fatal Outcomes of COVID-19 in Patients with Severe Acute Kidney Injury
has PubMed Central identifier	PMC7355571
has PubMed identifier	32503180
schema:publication	J Clin Med
resource representing a document's body	covid:f65899229ad904db5a2ad32dcc9eb0a7cbb38c04#body_text
is schema:about of	named entity 'AKI' named entity 'Network' named entity 'defined' named entity 'hazard ratio' named entity 'patients' named entity 'AKI' named entity 'COVID-19' named entity 'higher' named entity 'COVID-19' named entity 'Daegu' named entity '95% CI' named entity 'patients' named entity 'patients' named entity 'potential' named entity '1, 2' named entity 'Medical data' named entity 'South Korea' named entity 'dialysis' named entity '95% CI' named entity '7.48' named entity 'COVID' named entity 'risk factors' named entity 'confounding factors' named entity 'AKI' named entity 'Clinical Medicine' named entity 'patients' named entity 'renal function' named entity 'asymptomatic' named entity 'kidneys' named entity 'COVID' named entity 'AKI' named entity 'New York' named entity '11 March 2020' named entity 'higher risk' named entity 'hypervolemia' named entity 'risk factors' named entity 'AKI' named entity 'AKI' named entity 'World Health Organization' named entity 'SARS-CoV-2' named entity 'AKI' named entity 'AKI' named entity 'serum creatinine' named entity 'CKD' named entity 'AKI' named entity 'logistic regression' named entity 'risk factors' named entity 'CPK' named entity 'AKI' named entity 'COVID' named entity 'AKI' named entity 'COVID-19' named entity 'hydroxychloroquine' named entity 'odds ratio' named entity 'COVID' named entity 'prevalence rate' named entity 'serum creatinine' named entity 'oxygen therapy' named entity 'COVID' named entity 'AKI' named entity 'comorbid disease' named entity 'ARDS' named entity 'serum creatinine' named entity 'SARS-CoV' named entity 'China' named entity 'AKI' named entity 'proinflammatory cytokines' named entity 'gene'

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