About: Viral Double-Strand RNA-Binding Proteins Can Enhance Innate Immune Signaling by Toll-Like Receptor 3

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About: Viral Double-Strand RNA-Binding Proteins Can Enhance Innate Immune Signaling by Toll-Like Receptor 3 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Viral Double-Strand RNA-Binding Proteins Can Enhance Innate Immune Signaling by Toll-Like Receptor 3
Creator	Bhardwaj, Kanchan Chen, Alice Lai, Yvonne Mukhopadhyay, Suchetana Yi, Guanghui Zlotnick, Adam Cheng Kao, C Ranjith-Kumar, C Tragesser, Brady Valverde, Rodrigo
Source	Medline; PMC
abstract	Toll-like Receptor 3 (TLR3) detects double-stranded (ds) RNAs to activate innate immune responses. While poly(I:C) is an excellent agonist for TLR3 in several cell lines and in human peripheral blood mononuclear cells, viral dsRNAs tend to be poor agonists, leading to the hypothesis that additional factor(s) are likely required to allow TLR3 to respond to viral dsRNAs. TLR3 signaling was examined in a lung epithelial cell line by quantifying cytokine production and in human embryonic kidney cells by quantifying luciferase reporter levels. Recombinant 1b hepatitis C virus polymerase was found to enhance TLR3 signaling in the lung epithelial BEAS-2B cells when added to the media along with either poly(I:C) or viral dsRNAs. The polymerase from the genotype 2a JFH-1 HCV was a poor enhancer of TLR3 signaling until it was mutated to favor a conformation that could bind better to a partially duplexed RNA. The 1b polymerase also co-localizes with TLR3 in endosomes. RNA-binding capsid proteins (CPs) from two positive-strand RNA viruses and the hepadenavirus hepatitis B virus (HBV) were also potent enhancers of TLR3 signaling by poly(I:C) or viral dsRNAs. A truncated version of the HBV CP that lacked an arginine-rich RNA-binding domain was unable to enhance TLR3 signaling. These results demonstrate that several viral RNA-binding proteins can enhance the dsRNA-dependent innate immune response initiated by TLR3.
has issue date	2011-10-10(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0025837
bibo:pmid	22016778
has license	cc-by
sha1sum (hex)	f659c70f5c28f2b2694bc76b0a57b47d8d6362d5
schema:url	https://doi.org/10.1371/journal.pone.0025837
resource representing a document's title	Viral Double-Strand RNA-Binding Proteins Can Enhance Innate Immune Signaling by Toll-Like Receptor 3
has PubMed Central identifier	PMC3189932
has PubMed identifier	22016778
schema:publication	PLoS One
resource representing a document's body	covid:f659c70f5c28f2b2694bc76b0a57b47d8d6362d5#body_text
is schema:about of	named entity 'TLR3' named entity 'epithelial cell' named entity 'signaling' named entity 'viral' named entity 'activate' named entity 'enhancers' named entity 'Immune' named entity 'DOUBLE' named entity 'ENHANCE' named entity 'VIRAL' named entity 'TRUNCATED' named entity 'IMMUNE RESPONSES' named entity 'LEADING' named entity 'RNAS' named entity 'POOR' named entity 'EPITHELIAL' named entity 'POSITIVE' named entity 'THESE' named entity 'EXAMINED' named entity 'HBV' named entity 'INNATE IMMUNE RESPONSE' named entity 'POLYMERASE' named entity 'ADDITIONAL' named entity 'STRAND' named entity 'BEAS-2B' named entity 'BIND' named entity 'ENHANCER' named entity 'FAVOR' named entity 'TEND' named entity 'HUMAN' named entity 'MUTATED' named entity 'HYPOTHESIS' named entity 'FACTOR' named entity 'RNA-BINDING PROTEINS' named entity 'AGONISTS' named entity 'ENHANCERS' named entity 'CELL LINES' named entity 'RNA' named entity '28S' named entity 'GENOTYPE' named entity 'DEPENDENT' named entity 'CONFORMATION' named entity 'RNA VIRUSES' named entity 'DSRNA' named entity 'ENDOSOMES' named entity 'HEPATITIS B VIRUS' named entity 'TLR3' named entity 'EITHER' named entity 'PARTIALLY' named entity 'BETTER' named entity 'REQUIRED' named entity 'RESPOND TO' covid:arg/f659c70f5c28f2b2694bc76b0a57b47d8d6362d5 named entity 'SIGNALING' named entity 'CAPSID PROTEINS' named entity 'LUNG EPITHELIAL CELL LINE' named entity 'ALLOW' named entity 'RICH' named entity 'REPORTER' named entity 'EXCELLENT' named entity 'ENHANCE' named entity 'TOLL-LIKE RECEPTOR 3' named entity 'IMMUNE' named entity 'VIRAL' named entity 'STRAND' named entity 'PERIPHERAL BLOOD MONONUCLEAR CELLS' named entity 'SIGNALING' named entity 'LUNG' named entity 'MEDIA' named entity 'ADDED' named entity 'VERSION' named entity 'EMBRYONIC KIDNEY'

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