About: Comparative serum proteome expression of the steroid-induced femoral head osteonecrosis in adults

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About: Comparative serum proteome expression of the steroid-induced femoral head osteonecrosis in adults Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Comparative serum proteome expression of the steroid-induced femoral head osteonecrosis in adults
Creator	Zhang, Rongkai Li, Mingtao Cai, Dao Cai, Zhang Chen, Yuxian Dao, Dr Hu, Kunhua Xing, Bangrong Ye, Zhiqiang Zeng, Chun Zeng, Hua
Source	Medline; PMC
abstract	Steroid-induced osteonecrosis of the femoral head (SONFH) is a disabling, aseptic and ischemic disease that develops following steroid therapy. The pathogenesis of SONFH is unclear, so the early diagnosis and treatment for this disease is yet to be established. The purpose of the present study was to identify potential biomarkers for SONFH. The differential expression of serum proteins from patients with SONFH and healthy volunteers was analyzed by the proteomics method. The protein samples were labeled and subjected to isoelectric focusing and two-dimensional gel electrophoresis. The resultant protein spots were matched and quantified by an imaging analysis system. The differentially-expressed protein spots were subjected to in-gel trypsin digestion followed by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Significantly lower levels of complement component 3 (C3), C4, inter-α-trypsin inhibitor heavy chain H4 and α-2-macroglobulin were found in the serum of patients with SONFH. These proteins are reported to be actively involved in intravascular coagulation, apoptosis and reactive oxygen species imbalance, indicating that multiple pathological reactions occur in SONFH and these proteins may serve as potential biomarkers for the diagnosis of SONFH.
has issue date	2014-11-12(xsd:dateTime)
bibo:doi	10.3892/etm.2014.2069
bibo:pmid	25452779
has license	cc-by
sha1sum (hex)	f66963a9155d44a7f734c0f1d30cab3371cd99fa
schema:url	https://doi.org/10.3892/etm.2014.2069
resource representing a document's title	Comparative serum proteome expression of the steroid-induced femoral head osteonecrosis in adults
has PubMed Central identifier	PMC4247312
has PubMed identifier	25452779
schema:publication	Exp Ther Med
resource representing a document's body	covid:f66963a9155d44a7f734c0f1d30cab3371cd99fa#body_text
is schema:about of	named entity 'indicating' named entity 'ionization' named entity 'femoral head' named entity 'serum' named entity 'femoral head' named entity 'expression' named entity 'OSTEONECROSIS' named entity 'SERUM PROTEINS' named entity 'ISOELECTRIC FOCUSING' named entity 'SERVE' named entity 'IS A' named entity 'SERUM' named entity 'OSTEONECROSIS OF THE FEMORAL HEAD' named entity 'INTER-' named entity 'PRESENT' named entity 'THESE' named entity 'PROTEOME' named entity 'INDUCED' named entity 'SPOTS' named entity 'TRYPSIN DIGESTION' named entity 'DIAGNOSIS' named entity 'INTRAVASCULAR COAGULATION' named entity 'UNCLEAR' named entity 'MACROGLOBULIN' named entity 'INVOLVED' named entity 'TWO-DIMENSIONAL GEL ELECTROPHORESIS' named entity 'FOLLOWED BY' named entity 'IMBALANCE' named entity 'TREATMENT' named entity 'ANALYSIS SYSTEM' named entity 'ESTABLISHED' named entity 'OCCUR' named entity 'INDUCED' named entity 'SERUM' named entity 'REPORTED' named entity 'FEMORAL HEAD' named entity 'ADULTS' named entity 'STEROID' named entity 'EXPRESSION' named entity 'PROTEOMICS' named entity 'PROTEIN ' named entity 'TRYPSIN INHIBITOR' named entity 'LEVELS' named entity 'MATCHED' named entity 'DISEASE' named entity 'HEALTHY VOLUNTEERS' named entity 'LOWER' named entity 'INDICATING' named entity 'PURPOSE' named entity 'STEROID THERAPY' named entity 'ASEPTIC' named entity 'FOLLOWING' named entity 'GEL' named entity 'POTENTIAL' named entity 'PROTEINS' named entity 'DIFFERENTIAL EXPRESSION' named entity 'STUDY' named entity 'DEVELOPS' named entity 'LABELED' named entity 'DISABLING' named entity 'MULTIPLE' named entity 'REACTIVE OXYGEN SPECIES' named entity 'PATHOLOGICAL' named entity 'HEAVY CHAIN' named entity 'APOPTOSIS' named entity 'SAMPLES' named entity 'ANALYZED' named entity 'EARLY DIAGNOSIS' named entity 'MATRIX-ASSISTED LASER DESORPTION IONIZATION TIME-OF-FLIGHT MASS SPECTROMETRY' named entity 'STEROID' named entity 'REACTIONS'

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