About: Safety and Efficacy Profile of Echinacea purpurea to Prevent Common Cold Episodes: A Randomized, Double-Blind, Placebo-Controlled Trial

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About: Safety and Efficacy Profile of Echinacea purpurea to Prevent Common Cold Episodes: A Randomized, Double-Blind, Placebo-Controlled Trial Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Safety and Efficacy Profile of Echinacea purpurea to Prevent Common Cold Episodes: A Randomized, Double-Blind, Placebo-Controlled Trial
Creator	Eccles, R Jawad, M Klein, P Schoop, R Suter, A
source	Medline; PMC
abstract	Objective. To investigate the safety (risk) and efficacy (benefit) of Echinacea purpurea extract in the prevention of common cold episodes in a large population over a 4-month period. Methods. 755 healthy subjects were allocated to receive either an alcohol extract from freshly harvested E. purpurea (95% herba and 5% root) or placebo. Participants were required to record adverse events and to rate cold-related issues in a diary throughout the investigation period. Nasal secretions were sampled at acute colds and screened for viruses. Results. A total of 293 adverse events occurred with Echinacea and 306 with placebo treatment. Nine and 10% of participants experienced adverse events, which were at least possibly related to the study drug (adverse drug reactions). Thus, the safety of Echinacea was noninferior to placebo. Echinacea reduced the total number of cold episodes, cumulated episode days within the group, and pain-killer medicated episodes. Echinacea inhibited virally confirmed colds and especially prevented enveloped virus infections (P < 0.05). Echinacea showed maximal effects on recurrent infections, and preventive effects increased with therapy compliance and adherence to the protocol. Conclusions. Compliant prophylactic intake of E. purpurea over a 4-month period appeared to provide a positive risk to benefit ratio.
has issue date	2012-09-16(xsd:dateTime)
bibo:doi	10.1155/2012/841315
bibo:pmid	23024696
has license	cc-by
sha1sum (hex)	f763d5c729b3a02773062e212f3f2632d2ebb574
schema:url	https://doi.org/10.1155/2012/841315
resource representing a document's title	Safety and Efficacy Profile of Echinacea purpurea to Prevent Common Cold Episodes: A Randomized, Double-Blind, Placebo-Controlled Trial
has PubMed Central identifier	PMC3457740
has PubMed identifier	23024696
schema:publication	Evid Based Complement Alternat Med
resource representing a document's body	covid:f763d5c729b3a02773062e212f3f2632d2ebb574#body_text
is schema:about of	named entity 'total' named entity 'confirmed' named entity 'Echinacea purpurea' named entity 'ECHINACEA PURPUREA' named entity 'ISSUES' named entity 'GROUP' named entity 'INTAKE' named entity '293' named entity 'RATE' named entity 'ADHERENCE' named entity 'EXTRACT' named entity 'METHODS' named entity 'RECURRENT INFECTIONS' named entity 'RATIO' named entity 'DIARY' named entity 'KILLER' named entity 'EITHER' named entity 'POSSIBLY RELATED' named entity '0.05' named entity 'MONTH' named entity '755' named entity 'CONFIRMED' named entity 'MEDICATED' named entity 'EPISODES' named entity 'OCCURRED' named entity 'EFFECTS INCREASED' named entity 'INFECTIONS' named entity 'DRUG REACTIONS' named entity 'SAMPLED' named entity 'NASAL SECRETIONS' named entity 'PAIN' named entity 'POPULATION' named entity 'PREVENTION OF' named entity 'THERAPY COMPLIANCE' named entity 'ACUTE' named entity 'COMPLIANT' named entity 'COMMON COLD' named entity 'EFFECTS' named entity 'DOUBLE' named entity 'PROFILE' named entity 'EPISODES' named entity 'REDUCED' named entity 'BENEFIT' named entity 'PROTOCOL' named entity 'POSITIVE' named entity 'INHIBITED' named entity 'RELATED' named entity 'MAXIMAL' named entity 'ADVERSE EVENTS' named entity 'HEALTHY SUBJECTS' named entity 'PREVENTIVE' named entity 'PERIOD' named entity 'EXPERIENCED' named entity 'VIRUSES' named entity 'RANDOMIZED' named entity 'PLACEBO-CONTROLLED TRIAL' named entity 'LARGE' named entity 'DAYS' named entity 'SAFETY' named entity 'COMMON COLD' named entity 'BLIND' named entity 'EFFICACY' named entity '28P' named entity 'RISK' named entity 'PLACEBO' named entity 'PLACEBO TREATMENT' named entity 'TOTAL' named entity 'STUDY DRUG' named entity 'SAFETY' named entity 'TO RECORD' named entity 'REQUIRED' named entity 'CONCLUSIONS' named entity 'TO PREVENT' named entity 'ECHINACEA PURPUREA EXTRACT' named entity 'EFFICACY' named entity 'TO PROVIDE' named entity 'TOTAL NUMBER'

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