About: Differential Host Cell Gene Expression and Regulation of Cell Cycle Progression by Nonstructural Protein 11 of Porcine Reproductive and Respiratory Syndrome Virus

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About: Differential Host Cell Gene Expression and Regulation of Cell Cycle Progression by Nonstructural Protein 11 of Porcine Reproductive and Respiratory Syndrome Virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Differential Host Cell Gene Expression and Regulation of Cell Cycle Progression by Nonstructural Protein 11 of Porcine Reproductive and Respiratory Syndrome Virus
Creator	Sun, Yan Yoo, Dongwan Li, Dong Giri, Sumanprava Prasanth, Supriya
Source	Medline; PMC
abstract	Nonstructural protein 11 (nsp11) of porcine reproductive and respiratory syndrome virus (PRRSV) is a viral endoribonuclease with an unknown function. The regulation of cellular gene expression by nsp11 was examined by RNA microarrays using MARC-nsp11 cells constitutively expressing nsp11. In these cells, the interferon-β, interferon regulatory factor 3, and nuclear factor-κB activities were suppressed compared to those of parental cells, suggesting that nsp11 might serve as a viral interferon antagonist. Differential cellular transcriptome was examined using Affymetrix exon chips representing 28,536 transcripts, and after statistical analyses 66 cellular genes were shown to be upregulated and 104 genes were downregulated by nsp11. These genes were grouped into 5 major signaling pathways according to their functional relations: histone-related, cell cycle and DNA replication, mitogen activated protein kinase signaling, complement, and ubiquitin-proteasome pathways. Of these, the modulation of cell cycle by nsp11 was further investigated since many of the regulated genes fell in this particular pathway. Flow cytometry showed that nsp11 caused the delay of cell cycle progression at the S phase and the BrdU staining confirmed the cell cycle arrest in nsp11-expressing cells. The study provides insights into the understanding of specific cellular responses to nsp11 during PRRSV infection.
has issue date	2014-02-26(xsd:dateTime)
bibo:doi	10.1155/2014/430508
bibo:pmid	24719865
has license	cc-by
sha1sum (hex)	f7735a5236aeba514810bd4538357cb4f4e09fce
schema:url	https://doi.org/10.1155/2014/430508
resource representing a document's title	Differential Host Cell Gene Expression and Regulation of Cell Cycle Progression by Nonstructural Protein 11 of Porcine Reproductive and Respiratory Syndrome Virus
has PubMed Central identifier	PMC3955671
has PubMed identifier	24719865
schema:publication	Biomed Res Int
resource representing a document's body	covid:f7735a5236aeba514810bd4538357cb4f4e09fce#body_text
is schema:about of	named entity 'COMPARED' named entity 'REGULATION' named entity '2C CELL' named entity 'RNA MICROARRAYS' named entity 'SUPPRESSED' named entity 'PARENTAL' named entity 'INVESTIGATED' named entity 'UNKNOWN' named entity 'STUDY' named entity 'ACTIVITIES' named entity 'FUNCTIONAL' named entity 'STATISTICAL ANALYSES' named entity 'UNDERSTANDING' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS' named entity 'DIFFERENTIAL' named entity 'RESPONSES' named entity 'TRANSCRIPTS' named entity 'GENE EXPRESSION' named entity 'UPREGULATED' named entity 'CELL CYCLE' named entity 'EXAMINED' named entity 'SPECIFIC' named entity 'CELL CYCLE PROGRESSION' named entity 'PROTEASOME' named entity 'FLOW CYTOMETRY' named entity 'FELL' named entity 'CELLS' named entity 'FUNCTION' named entity 'DELAY' named entity 'STAINING' named entity 'GENES' named entity 'PROTEIN ' named entity 'MARC' named entity 'CONFIRMED' named entity 'FACTOR' named entity 'VIRAL' named entity 'CELL CYCLE ARREST' named entity 'SERVE' named entity 'TRANSCRIPTOME' named entity 'NUCLEAR' covid:arg/f7735a5236aeba514810bd4538357cb4f4e09fce named entity 'HOST CELL' named entity 'COMPLEMENT' named entity 'EXON' named entity 'PATHWAY' named entity 'AFFYMETRIX' named entity 'GENE EXPRESSION' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS' named entity 'PROTEIN ' named entity 'DIFFERENTIAL' named entity 'MAJOR' named entity 'INTERFERON' named entity 'CAUSED' named entity 'RELATIONS' named entity 'RELATED' named entity 'ENDORIBONUCLEASE' named entity 'ANTAGONIST' named entity 'INTERFERON REGULATORY FACTOR 3' named entity 'GROUPED' named entity 'UBIQUITIN' named entity 'HISTONE' named entity 'PATHWAYS' named entity 'PROVIDES' named entity 'CELLULAR' named entity 'SIGNALING PATHWAYS' named entity 'PARTICULAR' named entity 'MITOGEN ACTIVATED PROTEIN KINASE' named entity 'SIGNALING' named entity 'BRDU' named entity 'THEIR' named entity 'INFECTION' named entity 'ACCORDING' named entity 'MODULATION' named entity '104' named entity 'REGULATION OF CELL CYCLE PROGRESSION' named entity 'S PHASE' named entity 'THESE'

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