About: Overexpression of Tripartite Motif Conaining 55 (TRIM55) Inhibits Migration and Invasion of Hepatocellular Carcinoma (HCC) Cells via Epithelial-Mesenchymal Transition and Matrix Metalloproteinase-2 (MMP2)

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About: Overexpression of Tripartite Motif Conaining 55 (TRIM55) Inhibits Migration and Invasion of Hepatocellular Carcinoma (HCC) Cells via Epithelial-Mesenchymal Transition and Matrix Metalloproteinase-2 (MMP2) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Overexpression of Tripartite Motif Conaining 55 (TRIM55) Inhibits Migration and Invasion of Hepatocellular Carcinoma (HCC) Cells via Epithelial-Mesenchymal Transition and Matrix Metalloproteinase-2 (MMP2)
Creator	Li, Xinyu Huang, Lei Gao, Huang, Aeg, Lei Bcdf, Xinyu Bf, Weijie Li, *
topic	covid:f774e52f2267ee839ba5b026e12dfef588e15bfa#this
Source	Medline; PMC
abstract	BACKGROUND: Tripartite motif containing 55 (TRIM55) plays a regulatory role in assembly of sarcomeres, but few studies have assessed its function in hepatocellular carcinoma (HCC). MATREIAL/METHODS: Immunohistochemistry (IHC) was used to detect expression of TRIM55 in tissues samples of HCC patients. Transwell assay was used to study migration and invasion ability of HCC cells. Western blot and immunofluorescence (IF) were used to analyze mechanism of TRIM55 in cell migration and invasion. RESULTS: We found TRIM55 was downregulated in HCC tissues and was associated with prognosis of HCC patients. Cox regression analysis showed that TRIM55 was an independent risk factor of prognosis of HCC patients. Overexpression of TRIM55 was associated with lower cell migration and invasion ability, and it led to high expression of E-cadherin and low expression of Vimentin and MMP2. CONCLUSIONS: Our study found TRIM55 is an independent factor affecting the prognosis of HCC patients, and overexpression of TRIM55 inhibits migration and invasion of HCC cells through epithelial-mesenchymal transition and MMP2.
has issue date	2019-01-27(xsd:dateTime)
bibo:doi	10.12659/msm.910984
bibo:pmid	30685767
has license	cc-by-nc-nd
sha1sum (hex)	f774e52f2267ee839ba5b026e12dfef588e15bfa
schema:url	https://doi.org/10.12659/msm.910984
resource representing a document's title	Overexpression of Tripartite Motif Conaining 55 (TRIM55) Inhibits Migration and Invasion of Hepatocellular Carcinoma (HCC) Cells via Epithelial-Mesenchymal Transition and Matrix Metalloproteinase-2 (MMP2)
has PubMed Central identifier	PMC6360872
has PubMed identifier	30685767
schema:publication	Med Sci Monit
resource representing a document's body	covid:f774e52f2267ee839ba5b026e12dfef588e15bfa#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/f774e52f2267ee839ba5b026e12dfef588e15bfa
is schema:about of	named entity 'STUDIES' named entity 'REGULATORY ROLE' named entity 'HEPATOCELLULAR CARCINOMA' named entity 'ASSEMBLY' named entity 'ITS' named entity 'function' named entity 'WORK' named entity 'CONTAINING' named entity 'INVASION' named entity 'TRIPARTITE MOTIF' named entity 'COMMON' covid:arg/f774e52f2267ee839ba5b026e12dfef588e15bfa named entity 'NC-' named entity 'SARCOMERES' named entity 'EPITHELIAL-MESENCHYMAL TRANSITION' named entity 'ATTRIBUTION' named entity 'CELLS' named entity 'HEPATOCELLULAR CARCINOMA' named entity 'MATRIX METALLOPROTEINASE-2' named entity 'INTERNATIONAL' named entity 'MIGRATION' named entity 'LICENSED' named entity 'OVEREXPRESSION' named entity 'FUNCTION' named entity 'HAVE' named entity 'ASSESSED' named entity 'TRIPARTITE MOTIF' named entity 'BUT' named entity 'PLAYS' named entity 'Invasion' named entity 'sarcomeres' named entity 'Hepatocellular Carcinoma' named entity 'Epithelial-Mesenchymal Transition' named entity 'risk factor' named entity 'EMT' named entity 'HCC' named entity 'TRIM55' named entity 'matrigel' named entity 'prognosis' named entity 'HCC' named entity 'protein' named entity 'protein' named entity 'TRIM55' named entity 'TRIM55' named entity 'HCC' named entity 'E-cadherin' named entity 'TRIM55' named entity 'internal control' named entity 'TRIM55' named entity 'skeletal muscle' named entity 'Medical Ethics' named entity 'HCC' named entity 'TRIM55' named entity 'HCC' named entity 'reverse transcription' named entity 'transfect' named entity 'motility' named entity 'tumor stage' named entity 'Vimentin' named entity 'TRIM55' named entity 'risk factor' named entity 'early-stage' named entity 'TRIM55' named entity 'P<0.05' named entity 'prognosis' named entity 'vectors' named entity 'ORF' named entity 'epitope' named entity 'HCC' named entity 'TRIM55' named entity 'inflammatory response' named entity 'SARS-CoV'

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