About: Differential and convergent utilization of autophagy components by positive-strand RNA viruses

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About: Differential and convergent utilization of autophagy components by positive-strand RNA viruses Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Differential and convergent utilization of autophagy components by positive-strand RNA viruses
Creator	Mateo, Roberto Majzoub, Karim Abernathy, Emma Carette, Jan Bird, Sara Kirkegaardid, Karla Van Buuren, Nick
Source	PMC
abstract	Many viruses interface with the autophagy pathway, a highly conserved process for recycling cellular components. For three viral infections in which autophagy constituents are proviral (poliovirus, dengue, and Zika), we developed a panel of knockouts (KOs) of autophagy-related genes to test which components of the canonical pathway are utilized. We discovered that each virus uses a distinct set of initiation components; however, all three viruses utilize autophagy-related gene 9 (ATG9), a lipid scavenging protein, and LC3 (light-chain 3), which is involved in membrane curvature. These results show that viruses use noncanonical routes for membrane sculpting and LC3 recruitment. By measuring viral RNA abundance, we also found that poliovirus utilizes these autophagy components for intracellular growth, while dengue and Zika virus only use autophagy components for post-RNA replication processes. Comparing how RNA viruses manipulate the autophagy pathway reveals new noncanonical autophagy routes, explains the exacerbation of disease by starvation, and uncovers common targets for antiviral drugs.
has issue date	2019-01-04(xsd:dateTime)
bibo:doi	10.1371/journal.pbio.2006926
bibo:pmid	30608919
has license	cc-by
sha1sum (hex)	f776a35d824609f74d08fb3e86cdc3efb2530ab3
schema:url	https://doi.org/10.1371/journal.pbio.2006926
resource representing a document's title	Differential and convergent utilization of autophagy components by positive-strand RNA viruses
has PubMed Central identifier	PMC6334974
has PubMed identifier	30608919
schema:publication	PLoS Biol
resource representing a document's body	covid:f776a35d824609f74d08fb3e86cdc3efb2530ab3#body_text
is schema:about of	named entity 'initiation' named entity 'RNA' named entity 'recruitment' named entity 'gene' named entity 'constituents' named entity 'set' named entity 'dengue' named entity 'viruses' named entity 'conserved' named entity 'disease' named entity 'intracellular' named entity 'genes' named entity 'virus' named entity 'autophagy' named entity 'viruses' named entity 'RNA' named entity 'antiviral drugs' named entity 'autophagy' named entity 'viruses' named entity 'virus' named entity 'viral RNA' named entity 'autophagy' named entity 'autophagy' named entity 'canonical pathway' named entity 'autophagy' named entity 'RNA viruses' named entity 'MOI' named entity 'VPS34' named entity 'LC3' named entity 'Autophagy' named entity 'viral RNA' named entity 'siRNAs' named entity 'autophagy' named entity 'G120A' named entity 'infection' named entity 'DENV' named entity 'GFP' named entity 'LC3-I' named entity 'autophagy' named entity 'LC3' named entity 'autophagy' named entity 'ULK1' named entity 'DENV' named entity 'DENV' named entity 'NS3' named entity 'picornaviruses' named entity 'plaque forming units' named entity 'DENV' named entity 'proviral' named entity 'cell lines' named entity 'cytoplasmic' named entity 'viral RNA' named entity 'GFP' named entity 'single-cell' named entity 'DMVs' named entity 'equine arteritis virus' named entity 'antiviral' named entity 'vesicles' named entity 'LC3' named entity 'ATG5' named entity 'LC3' named entity 'cell lysates' named entity 'AMPK' named entity 'autophagy' named entity 'gene disruption' named entity 'phosphorylation' named entity 'guanidine' named entity 'VPS34' named entity 'LC3' named entity 'LC3' named entity 'electron' named entity 'autophagy' named entity 'gene' named entity 'ERT2' named entity 'fusion protein'

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