About: From APOBEC to ZAP: Diverse mechanisms used by cellular restriction factors to inhibit virus infections

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: From APOBEC to ZAP: Diverse mechanisms used by cellular restriction factors to inhibit virus infections Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	From APOBEC to ZAP: Diverse mechanisms used by cellular restriction factors to inhibit virus infections
Creator	Bonifati, Serena Chemudupati, Mahesh Wu, Li Zani, Ashley Mcmichael, Temet Yount, Jacob Kenney, Adam
source	Elsevier; Medline; PMC
abstract	Abstract Antiviral restriction factors are cellular proteins that inhibit the entry, replication, or spread of viruses. These proteins are critical components of the innate immune system and function to limit the severity and host range of virus infections. Here we review the current knowledge on the mechanisms of action of several restriction factors that affect multiple viruses at distinct stages of their life cycles. For example, APOBEC3G deaminates cytosines to hypermutate reverse transcribed viral DNA; IFITM3 alters membranes to inhibit virus membrane fusion; MXA/B oligomerize on viral protein complexes to inhibit virus replication; SAMHD1 decreases dNTP intracellular concentrations to prevent reverse transcription of retrovirus genomes; tetherin prevents release of budding virions from cells; Viperin catalyzes formation of a nucleoside analogue that inhibits viral RNA polymerases; and ZAP binds virus RNAs to target them for degradation. We also discuss countermeasures employed by specific viruses against these restriction factors, and mention secondary functions of several of these factors in modulating immune responses. These important examples highlight the diverse strategies cells have evolved to combat virus infections.
has issue date	2019-03-31(xsd:dateTime)
bibo:doi	10.1016/j.bbamcr.2018.09.012
bibo:pmid	30290238
has license	els-covid
sha1sum (hex)	f77b97ac01d151017fa1f095998590769aab47cd
schema:url	https://doi.org/10.1016/j.bbamcr.2018.09.012
resource representing a document's title	From APOBEC to ZAP: Diverse mechanisms used by cellular restriction factors to inhibit virus infections
has PubMed Central identifier	PMC6334645
has PubMed identifier	30290238
schema:publication	Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
resource representing a document's body	covid:f77b97ac01d151017fa1f095998590769aab47cd#body_text
is schema:about of	named entity 'virus' named entity 'deaminates' named entity 'binds' named entity 'APOBEC3G' named entity 'reverse transcription' named entity 'factors' named entity 'combat' named entity 'viruses' named entity 'MXA' named entity 'THEIR' named entity 'PROTEIN COMPLEXES' named entity 'BINDS' named entity 'SPREAD' named entity 'CURRENT' named entity 'VIRUS REPLICATION' named entity 'POLYMERASES' named entity 'LIMIT' named entity 'FUNCTION' named entity 'DEGRADATION' named entity 'NUCLEOSIDE ANALOGUE' named entity 'S T' named entity 'ACTION' named entity 'ENTRY' named entity 'FUNCTIONS' named entity 'REVERSE' named entity 'MULTIPLE' named entity 'PREVENTS' named entity 'MECHANISMS' named entity 'target' named entity 'budding' named entity 'cellular proteins' named entity 'concentrations' named entity 'modulating' named entity 'host range' named entity 'virus' named entity 'secondary' named entity 'protein complexes' named entity 'RNAs' named entity 'oligomerize' named entity 'reverse transcribed' named entity 'These' named entity 'current' named entity 'restriction' named entity 'virus infections' named entity 'immune responses' named entity 'nucleoside analogue' named entity 'mechanisms of action' named entity 'reverse transcription' named entity 'viral protein' named entity 'APOBEC3G' named entity 'innate immune' named entity 'retrovirus' named entity 'virus' named entity 'virus' named entity 'catalyzes' named entity 'virions' named entity 'host range' named entity 'proteasomal degradation' named entity 'antiviral activity' named entity 'acute myeloid leukemia' named entity 'apoptosis' named entity 'IFITM3' named entity 'protein' named entity 'RNAs' named entity 'dimers' named entity 'viral proteins' named entity 'restriction factor' named entity 'MxA' named entity 'deoxyuridine' named entity 'mechanisms of action' named entity 'homeostasis' named entity 'protein' named entity 'Moloney murine leukemia virus' named entity 'HIV-1' named entity 'SAMHD1'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software