About: A New Genotype of Feline Morbillivirus Infects Primary Cells of the Lung, Kidney, Brain and Peripheral Blood

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A New Genotype of Feline Morbillivirus Infects Primary Cells of the Lung, Kidney, Brain and Peripheral Blood
Creator	Heenemann, Kristin Vahlenkamp, Thomas Busch, Johannes Böttcher, Denny Eschke, Maria Heilmann, Romy Reinert, Anja Scheffler, Kira Seeger, Johannes Sieg, Michael Vahlenkamp, Annett
topic	covid:f781ae4966ab37b3cc7cf282c732db401856870b#this
Source	Medline; PMC
abstract	Paramyxoviruses comprise a large number of diverse viruses which in part give rise to severe diseases in affected hosts. A new genotype of feline morbillivirus, tentatively named feline morbillivirus genotype 2 (FeMV-GT2), was isolated from urine of cats with urinary tract diseases. Whole genome sequencing showed about 78% nucleotide homology to known feline morbilliviruses. The virus was isolated in permanent cell lines of feline and simian origin. To investigate the cell tropism of FeMV-GT2 feline primary epithelial cells from the kidney, the urinary bladder and the lung, peripheral blood mononuclear cells (PBMC), as well as organotypic brain slice cultures were used for infection experiments. We demonstrate that FeMV-GT2 is able to infect renal and pulmonary epithelial cells, primary cells from the cerebrum and cerebellum, as well as immune cells in the blood, especially CD4(+) T cells, CD20(+) B cells and monocytes. The cats used for virus isolation shed FeMV-GT2 continuously for several months despite the presence of neutralizing antibodies in the blood. Our results point towards the necessity of increased awareness for this virus when clinical signs of the aforementioned organs are encountered in cats which cannot be explained by other etiologies.
has issue date	2019-02-09(xsd:dateTime)
bibo:doi	10.3390/v11020146
bibo:pmid	30744110
has license	cc-by
sha1sum (hex)	f781ae4966ab37b3cc7cf282c732db401856870b
schema:url	https://doi.org/10.3390/v11020146
resource representing a document's title	A New Genotype of Feline Morbillivirus Infects Primary Cells of the Lung, Kidney, Brain and Peripheral Blood
has PubMed Central identifier	PMC6410220
has PubMed identifier	30744110
schema:publication	Viruses
resource representing a document's body	covid:f781ae4966ab37b3cc7cf282c732db401856870b#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/f781ae4966ab37b3cc7cf282c732db401856870b
is schema:about of	named entity 'infect' named entity 'lines' named entity 'clinical signs' named entity 'cats' named entity 'primary' named entity 'Genotype' named entity 'BRAIN' named entity 'GENOTYPE' named entity 'SEVERE' named entity 'NAMED' named entity 'GT2' named entity 'FELINE MORBILLIVIRUS' named entity 'INCREASED' named entity 'INFECTION' named entity 'GENOTYPE 2' named entity 'BLOOD' named entity 'CD4' named entity 'NEW' named entity 'SIMIAN' named entity 'ISOLATED' named entity 'PERIPHERAL BLOOD MONONUCLEAR CELLS' named entity 'PRIMARY CELLS' named entity 'THE CELL' named entity 'CEREBELLUM' named entity 'COMPRISE' named entity 'MONOCYTES' named entity 'INFECTS' named entity 'RESULTS' named entity 'VIRUSES' named entity 'PERMANENT' named entity 'DISEASES' named entity 'PRIMARY' named entity 'BRAIN SLICE' named entity 'PRIMARY CELLS' named entity 'LUNG' named entity 'PERIPHERAL BLOOD' named entity 'URINE' named entity 'KIDNEY' named entity 'LARGE' named entity 'HOSTS' named entity 'ABOUT' named entity 'WHOLE GENOME SEQUENCING' named entity 'EXPLAINED' named entity 'USED' named entity 'HOMOLOGY' named entity 'VIRUS' named entity 'ETIOLOGIES' named entity 'CELL LINES' named entity 'IMMUNE CELLS' named entity 'CULTURES' named entity 'GENOTYPE' named entity 'NEW' named entity 'POINT' named entity 'VIRUS ISOLATION' named entity 'ORGANS' named entity 'URINARY TRACT DISEASES' named entity 'MORBILLIVIRUSES' named entity 'AFFECTED' named entity 'LUNG' named entity 'KNOWN' named entity 'PULMONARY' named entity 'OUR' named entity 'RENAL' named entity 'ORIGIN' named entity 'NUMBER OF' named entity 'FELINE MORBILLIVIRUS' named entity 'TROPISM' named entity 'DIVERSE' named entity 'TO INFECT'

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